α-hexylpelargonic acid | 37165-63-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α-hexylpelargonic acid
• 英文别名: 2-hexyl-nonanoic acid；2-Hexyl-nonansaeure；alpha-Hexylpelargonic acid；2-hexylnonanoic acid
• CAS: 37165-63-2
• 化学式: C₁₅H₃₀O₂
• 分子量: 242.402
• InChiKey: FYSUCIRARGQXCJ-UHFFFAOYSA-N

物化性质

• 沸点：
  355.5±10.0 °C(Predicted)
• 密度：
  0.894±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2915900090

反应信息

• 作为产物：
  描述：

  7-十四碳烯 、 一氧化碳 在 palladium diacetate 盐酸 、 四丁基溴化铵 作用下， 以 水 为溶剂， 109.85 ℃ 、5.0 MPa 条件下， 反应 2.0h， 以55.9%的产率得到α-hexylpelargonic acid
  参考文献：
  名称：

  Phosphine-free catalytic system for the carboxylation of olefins with carbon oxide

  摘要：

  DOI：

  10.1007/s10631-005-0032-3

文献信息

• INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20170258805A1

  公开（公告）日：2017-09-14

  Compounds and salts thereof which are acyl-sulfonamides or certain carboxylic acids and which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include 2-aminothiazoles and triazolothiadiazines, particularly 3,6,7-substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 2-amino and salts thereof. Methods for inhibiting growth or attenuating virulence of microbial pathogens including mycobacterium , for example, M. tuberculosis and M. smegmatis and Klebsiella , for example, Klebsiella pneumoniae . Methods for inhibiting eukaryotic human and animal pathogens, and fungi and nematodes in particular. Methods for treatment of infections by prokaryotic and eukaryotic pathogens employing compounds of the invention.

  其酰基磺酰胺或某些羧酸的化合物及其盐，能够抑制微生物生长或减弱病原微生物的毒力，并且能够抑制UDP-半乳糖吡喃糖异构酶（UGM）。该发明的化合物包括2-氨基噻唑和三唑噻二嗪，特别是3,6,7-取代的7H-[1,2,4]三唑噻二嗪和其盐，以及2-氨基。抑制微生物病原体生长或减弱其毒力的方法包括结核分枝杆菌（例如结核分枝杆菌和平滑分枝杆菌）和克雷伯氏菌（例如肺炎克雷伯氏菌）等微生物病原体。抑制真核人类和动物病原体、真菌和线虫的方法，特别是治疗原核和真核病原体感染的方法，采用了该发明的化合物。
• [EN] SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION<br/>[FR] DÉGRONIMÈRES SPIROCYCLIQUES POUR LA DÉGRADATION DE PROTÉINES CIBLES
  申请人：C4 THERAPEUTICS INC

  公开号：WO2017197036A1

  公开（公告）日：2017-11-16

  This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

  这项发明提供了具有螺环式E3泛素连接酶靶向基团（Degrons）的化合物，这些化合物可以直接使用，也可以与靶向配体连接，用于选定用于体内降解的蛋白质，并提供了使用方法、组合物以及其制备方法。
• NOVEL 5-HYDROXY PYRIDINE-BASED COMPOUND FOR USE AS P2X1 AND P2X3 RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20200131131A1

  公开（公告）日：2020-04-30

  The present invention relates to novel 5-hydroxy pyridine-based compounds useful as P2X1 and P2X3 receptor antagonists and compositions comprising the same. The compounds according to the present invention have an activity of strongly antagonizing P2X1 and P2X3 receptors, and thus can be effectively used as a drug for treating or preventing chronic inflammatory diseases or neuropathic pain diseases caused by P2X1 and P2X3 receptor activity.

  本发明涉及一种新型的以5-羟基吡啶为基础的化合物，其作为P2X1和P2X3受体拮抗剂，并包含该化合物的组合物。根据本发明的化合物具有强烈拮抗P2X1和P2X3受体的活性，因此可有效用作治疗或预防由P2X1和P2X3受体活性引起的慢性炎症性疾病或神经病理性疼痛疾病的药物。
• ENCAPSULATES
  申请人：SMETS Johan

  公开号：US20130039962A1

  公开（公告）日：2013-02-14

  The present application relates to encapsulates, compositions, products comprising such encapsulates, and processes for making and using such encapsulates. Such encapsulates comprise a core comprising a perfume and a shell that encapsulates said core, such encapsulates may optionally comprise a parametric balancing agent, such shell comprising one or more azobenzene moieties.

  本申请涉及封装、组合物、包含这种封装物的产品以及制备和使用这种封装物的过程。这种封装物包括一个包含香水的核心和封装该核心的外壳，这种封装物可以选择性地包含参数平衡剂，该外壳包括一个或多个偶氮苯基团。
• ESTER COMPOUNDS AND LUBRICATING OIL COMPOSITION
  申请人：Kao Corporation

  公开号：EP0903335A1

  公开（公告）日：1999-03-24

  Ester compounds possessing heat stability in the presence of a metal and prepared from di- to nona- hydric hindered alcohols having 5 to 15 carbon atoms and saturated aliphatic monocarboxylic acids having 3 to 20 carbon atoms or derivatives thereof, characterized in that the proportion of the branched carboxylic acids or derivatives thereof in all the carboxylic acids or derivatives thereof is at least 50 % by mole and the ester compounds have a hydroxyl value of at most 30 mg KOH/g and an acid value after the sealed tube test of at most 10 mg KOH/g: and a lubricating oil composition characterized by containing at least 20 % by weight of the ester compounds. Thus the invention provides ester compounds possessing excellent heat stability in the presence of a metal, and a lubricating oil composition and a hydraulic fluid composition for refrigerators, each composed mainly of the ester compounds.

  在金属存在下具有热稳定性的酯类化合物，由具有 5 至 15 个碳原子的二水至非 水受阻醇和具有 3 至 20 个碳原子的饱和脂肪族一元羧酸或其衍生物制备、其特征在于支链羧酸或其衍生物在所有羧酸或其衍生物中所占比例至少为 50%（按摩尔计），且酯类化合物的羟值不超过 30 毫克 KOH/克，密封管测试后的酸值不超过 10 毫克 KOH/克：以及一种润滑油组合物，其特征是含有至少 20% （按重量计）的酯类化合物。因此，本发明提供了在金属存在下具有优异热稳定性的酯类化合物，以及主要由这些酯类化合物组成的用于冰箱的润滑油组合物和液压油组合物。