4-(Chlorosulfonyl)-L-phenylalanine | 84053-07-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(Chlorosulfonyl)-L-phenylalanine
• 英文别名: (2S)-2-amino-3-(4-chlorosulfonylphenyl)propanoic acid
• CAS: 84053-07-6
• 化学式: C₉H₁₀ClNO₄S
• 分子量: 263.7
• InChiKey: YZDSGFYHZHYQDO-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NEW 3-PHENYLPROPIONIC ACID DERIVATIVES
  申请人：Majka Zbigniew

  公开号：US20070219259A1

  公开（公告）日：2007-09-20

  The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO-C 1 -C 4 -alkyl group; Y represents NH, N—C 1 -C 10 -alkyl, O, or S; Z represents NH, N—C 1 -C 10 -alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C 1 -C 10 -alkyl, N-aryl, NSO 2 —C 1 -C 10 -alkyl, N—SO 2 -aryl, or N—SO 2 -heteroaryl; R, to R 8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.

  本发明涉及新的化合物，是式I的3-苯基丙酸衍生物，其中W代表COOH基团或其生物异构体，或-COO-C1-C4-烷基基团；Y代表NH，N-C1-C10-烷基，O或S；Z代表NH，N-C1-C10-烷基，N-芳基，N-杂环芳基，S或O；X代表O，S，NH，N-C1-C10-烷基，N-芳基，NSO2-C1-C10-烷基，N-SO2-芳基或N-SO2-杂环芳基；R到R8独立地代表氢原子或在说明中定义的取代基；A如说明中所定义；n表示0到4之间的整数，包括0和4；以及其药学上可接受的盐。这些化合物是PPAR-gamma受体的配体，可用作药物。
• New 3-phenylpropionic acid derivatives
  申请人：Majka Zbigniew

  公开号：US20070088061A1

  公开（公告）日：2007-04-19

  The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C 1 -C 4 -alkyl group; Y represents NH, N—C 1 -C 10 -alkyl, O, or S; Z represents NH, N—C 1 -C 10 -alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C 1 -C 10 -alkyl, N-aryl, NSO 2 —C 1 -C 10 -alkyl, N—SO 2 -aryl, or N—SO 2 -heteroaryl; R 1 to R 8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.

  该发明涉及一种新化合物，为公式I的3-苯基丙酸衍生物，其中W代表COOH基团或其生物异构体，或-COO-C1-C4-烷基基团；Y代表NH、N-C1-C10-烷基、O或S；Z代表NH、N-C1-C10-烷基、N-芳基、N-杂环芳基、S或O；X代表O、S、NH、N-C1-C10-烷基、N-芳基、NSO2-C1-C10-烷基、N-SO2-芳基或N-SO2-杂环芳基；R1到R8各自独立地代表氢原子或描述中定义的取代基；A如描述中所定义；n代表0到4的整数，包括0和4；以及其药学上可接受的盐。这些化合物是PPAR-gamma受体的配体，可用作药物。
• 3-Phenylpropionic acid derivatives
  申请人：Majka Zbigniew

  公开号：US20070161799A1

  公开（公告）日：2007-07-12

  The invention relates to a method of treatment and/or prophylaxis of diseases and conditions mediated by peroxysome proliferator-activated receptor gamma (PPARγ) in a mammal subject in need thereof, said method comprising administration to said mammal a compound of formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically or prophylactically effective amount wherein in formula (I) W represents a COOH group or its bioisosters, or COO—C 1 -C 4 -alkyl group; Y represents NH or N—C 1 -C 10 -alkyl; Z represents NH, N—C 1 -C 10 -alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C 1 -C 10 -alkyl, N-aryl, NSO 2 —C 1 -C 10 -alkyl, N—SO 2 -aryl, or N S0 2 -heteroaryl; R 1 to R 6 each independently represents a hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive. The compounds of formula (I) are the ligands of PPAR-gamma receptor.

  本发明涉及一种治疗和/或预防哺乳动物患有由过氧化物酶体增殖物激活受体γ（PPARγ）介导的疾病和病状的方法，该方法包括向该哺乳动物施用公式（I）的化合物或其药学上可接受的盐，其量在治疗或预防方面有效，其中在公式（I）中W代表COOH基团或其生物等价物，或COO-C1-C4-烷基基团；Y代表NH或N-C1-C10-烷基；Z代表NH，N-C1-C10-烷基，N-芳基，N-杂环芳基，S或O；X代表O，S，NH，N-C1-C10-烷基，N-芳基，NSO2-C1-C10-烷基，N-SO2-芳基，或NS02-杂环芳基；R1至R6各自独立地表示氢原子或在说明书中定义的取代基；A如说明书中所定义；n表示整数0至4，包括在内。公式（I）的化合物是PPAR-γ受体的配体。
• US7220766B2
  申请人：——

  公开号：US7220766B2

  公开（公告）日：2007-05-22
• US7309791B2
  申请人：——

  公开号：US7309791B2

  公开（公告）日：2007-12-18