4-Allylsulfanyl-2-methoxy-phenylamine | 141101-07-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-Allylsulfanyl-2-methoxy-phenylamine
• 英文别名: 2-Methoxy-4-prop-2-enylsulfanylaniline
• CAS: 141101-07-7
• 化学式: C₁₀H₁₃NOS
• 分子量: 195.285
• InChiKey: DAFPEWPRRUZCNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氯-2-硝基苯甲醚 在 sodium dithionite 、 sodium hydride 作用下， 以 甲醇 、 水 为溶剂， 反应 2.84h， 生成 4-Allylsulfanyl-2-methoxy-phenylamine
  参考文献：
  名称：

  Synthesis and Anti-inflammatory Activity of Antioxidants, 4-Alkylthio-o-anisidine Derivatives.

  摘要：

  为了寻找针对自身免疫疾病的抗炎药物，我们合成了具有抗氧化活性的4-烷基硫-o-氨基苯甲醚衍生物，并测试了它们对小鼠阿尔图斯反应的抗炎活性。实验表明，包括阿尔图斯反应、芒果糖蛋白A、佛波酯和焦磷酸诱导的大鼠水肿在内的实验性炎症都被4-丙基硫-o-氨基苯甲醚抑制，该化合物抑制了大鼠脑匀浆的自氧化，并抑制了小鼠血浆中脂多糖诱导的丙二醛水平升高。抗氧化剂可能在活性氧种类发挥重要作用的免疫复合物型炎症中是一种有效的药物。

  DOI：

  10.1248/cpb.40.351

文献信息

• Liposomes containing tetraether lipid derivatives
  申请人：Bernina Plus GmbH

  公开号：EP2711369A1

  公开（公告）日：2014-03-26

  The present invention relates to liposomes comprising a tetraether lipid of formula (1) or a salt thereof and at least one sterol, wherein the molar ratio of tetraether lipid to sterol is from 1 : 1 to 1 : 10.

  本发明涉及一种含有四醚脂质的脂质体，其化学式为（1）或其盐，并且至少含有一种甾醇，其中四醚脂质与甾醇的摩尔比为1：1到1：10。
• Multiphasic compositions
  申请人：SEQUESSOME TECHNOLOGY HOLDINGS LIMITED

  公开号：US10744090B2

  公开（公告）日：2020-08-18

  The present invention relates to compositions comprising a colloidal dispersion and an Agent of Interest (“AOI”), wherein the colloidal dispersion comprises deformable colloidal particles and wherein the AOI is not associated with the deformable colloidal particles. The present invention also provides kits and transdermal drug release devices comprising the compositions of the present invention, and the use of these compositions in medicine, skin care and cosmetics.

  本发明涉及包含胶体分散体和利益相关剂（"AOI"）的组合物，其中胶体分散体包含可变形胶体颗粒，且AOI与可变形胶体颗粒不相关联。本发明还提供了包含本发明组合物的试剂盒和透皮药物释放装置，以及这些组合物在医药、皮肤护理和化妆品中的用途。
• Formulation for topical non-invasive application in vivo
  申请人：——

  公开号：US20020064524A1

  公开（公告）日：2002-05-30

  A formulation comprising molecular arrangements capable of penetrating pores in a barrier, owing to penetrant adaptability, despite the fact that the average diameter of said pores is smaller than the average penetrant diameter, provided that the penetrants can transport agents or else enable agent permeation through the pores after penetrants have entered pores, characterized in that the formulation comprises at least one consistency builder in an amount that increases the formulation to maximally 5 Nm/s so that spreading over, and retention at, the application area is enabled and/or at least one antioxidant in an amount that reduces the increase of oxidation index to less than 100% per 6 months and/or at least one microbicide in an amount that reduces the bacterial count of 1 million germs added per g of total mass of the formulation to less than 100 in the case of aerobic bacteria, to less than 10 in the case of entero-bacteria, and to less than 1 in the case of Pseudomonas aeruginosa or Staphilococcus aureus, after a period of 4 days.

  一种制剂，其分子排列由于渗透剂的适应性而能够穿透屏障中的孔隙，尽管所述孔隙的平均直径小于渗透剂的平均直径，条件是渗透剂能够输送制剂或在渗透剂进入孔隙后使制剂能够通过孔隙渗透，其特征在于该制剂包含至少一种稠度促进剂，其用量能够使制剂的稠度最大增加到 5 Nm/s，从而能够在涂抹区铺展并保持、和/或至少一种抗氧化剂，其用量应能将氧化指数的增加降低到每 6 个月小于 100%，和/或至少一种杀微生物剂，其用量应能将每克制剂总重量中加入的 100 万个细菌数降低到：需氧细菌小于 100 个，肠道细菌小于 10 个，假单胞菌小于 1 个。 铜绿假单胞菌 或 金黄色葡萄球菌、 4 天后。
• Method for the improvement of transport across adaptable semi-permeable barriers
  申请人：——

  公开号：US20030099694A1

  公开（公告）日：2003-05-29

  The invention relates to a method, a kit and a device for controlling the flux of penetrants across an adaptable semi-permeable porous barrier, the method comprising the steps of: preparing a formulation by suspending or dispersing said penetrants in a polar liquid in the form of fluid droplets surrounded by a membrane-like coating of one or several layers, said coating comprising at least two kinds of forms of amphiphilic substances with a tendency to aggregate, said penerants being able to transport agents through the pores of said barrier or to enable agent permeation through the pores of said barrier after penetrants have entered the pores, selecting a dose amount of said penetrants to be applied on a predetermined area of said barrier to control the flux of said penetrants across said barrier, and applying the selected dose amount of said formulation containing said penetrants onto said area of said porous barrier.

  本发明涉及一种控制渗透剂通过可适应的半渗透多孔屏障的方法、套件和装置，该方法包括以下步骤：制备配方，将渗透剂悬浮或分散在极性液体中，形成液滴，液滴周围有一层或多层膜状涂层，所述涂层包括至少两种具有聚集倾向的两性物质、所述渗透剂能够通过所述阻隔层的孔隙传输药剂，或在渗透剂进入孔隙后使药剂能够通过所述阻隔层的孔隙渗透，选择所述渗透剂的剂量用在所述阻隔层的预定区域，以控制所述渗透剂通过所述阻隔层的通量，并将选定剂量的含有所述渗透剂的所述制剂用在所述多孔阻隔层的所述区域。
• IMPROVED FORMULATION FOR TOPICAL NON-INVASIVE APPLICATION IN VIVO
  申请人：IDEA AG

  公开号：EP1140021B1

  公开（公告）日：2004-08-04