2,2-dimethyl-5-[(E,E,)-1-methyl-4-(p-methoxyphenyl)butadienyl]-3(2H)-furanone | 136823-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,2-dimethyl-5-[(E,E,)-1-methyl-4-(p-methoxyphenyl)butadienyl]-3(2H)-furanone
• 英文别名: 5-[(2E,4E)-5-(4-methoxyphenyl)penta-2,4-dien-2-yl]-2,2-dimethylfuran-3-one
• CAS: 136823-59-1
• 化学式: C₁₈H₂₀O₃
• 分子量: 284.355
• InChiKey: DZFAQJFVLVHCSF-CZDMKBBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-5-(3-acetyloxy-1-methyl-1-propenyl)-3(2H)-furanone 、 4-甲氧基苯甲醛 生成 2,2-dimethyl-5-[(E,E,)-1-methyl-4-(p-methoxyphenyl)butadienyl]-3(2H)-furanone
  参考文献：
  名称：

  Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates

  摘要：

  In an attempt to determine some of the structural features of geiparvarin (1) that account for its cytostatic activity in vitro, a series of geiparvarin analogues (10a-i, 1, 12, and 14-16) which contain novel modifications in the region of the olefinic double bond and of the coumarin moiety have been designed and synthesized. Among the derivatives containing a carbamate moiety, only the analogues containing a carbamate group linked to an alkyl moiety 10b-i were endowed with potent cytostatic activity, whereas the corresponding benzene derivative 10a was devoid of any antiproliferative activity. 6-Methoxygeiparvarin 101 proved equally effective as geiparvin (1), while compounds containing an additional double bond at the side chain (12 and 14-16) were invariably 5-100-fold less effective than geiparvarin. Diene derivative 15, bearing a coumarin moiety, was essentially inactive against murine (L1210, FM3A) tumor cells but exhibited good activity against human (Molt/4F, MT-4) tumor cells.

  DOI：

  10.1021/jm00115a004

文献信息

• Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates
  作者：Daniele Simoni、Stefano Manfredini、Mojgan Aghazadeh Tabrizi、Rita Bazzanini、Pier G. Baraldi、Jan Balzarini、Erik De Clercq

  DOI：10.1021/jm00115a004

  日期：1991.11

  In an attempt to determine some of the structural features of geiparvarin (1) that account for its cytostatic activity in vitro, a series of geiparvarin analogues (10a-i, 1, 12, and 14-16) which contain novel modifications in the region of the olefinic double bond and of the coumarin moiety have been designed and synthesized. Among the derivatives containing a carbamate moiety, only the analogues containing a carbamate group linked to an alkyl moiety 10b-i were endowed with potent cytostatic activity, whereas the corresponding benzene derivative 10a was devoid of any antiproliferative activity. 6-Methoxygeiparvarin 101 proved equally effective as geiparvin (1), while compounds containing an additional double bond at the side chain (12 and 14-16) were invariably 5-100-fold less effective than geiparvarin. Diene derivative 15, bearing a coumarin moiety, was essentially inactive against murine (L1210, FM3A) tumor cells but exhibited good activity against human (Molt/4F, MT-4) tumor cells.