N-tert-butyl-N'-benzoyl-N-3,5-dimethyl-benzoylhydrazine | 112426-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-tert-butyl-N'-benzoyl-N-3,5-dimethyl-benzoylhydrazine
• 英文别名: RH-5849；N'-t-butyl-N-benzoyl-N'-(3,5-dimethylbenzoyl)hydrazine；N'-benzoyl-N-tert-butyl-3,5-dimethylbenzohydrazide
• CAS: 112426-79-6
• 化学式: C₂₀H₂₄N₂O₂
• 分子量: 324.423
• InChiKey: RIQWCSUNJYMQFI-UHFFFAOYSA-N

物化性质

• 熔点：
  206.5 °C
• 密度：
  1.099±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二氯化硫 、 N-tert-butyl-N'-benzoyl-N-3,5-dimethyl-benzoylhydrazine 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 N'-benzoyl-N-(tert-butyl)-N'-(chlorothio)-3,5-dimethylbenzohydrazide
  参考文献：
  名称：

  的合成与杀虫评价ñ -叔丁基- ñ ' -硫代[1-（6-氯-3-吡啶甲基）-2- nitroiminoimidazolidine] - ñ，Ñ '-diacylhydrazines

  摘要：

  一系列新颖ñ -叔丁基- ñ ' -硫代[1-（6-氯-3-吡啶甲基）-2- nitroiminoimidazolidine] - ñ，Ñ '-diacylhydrazines被chlorosulfenyl的反应，合成（ñ -叔在氢化钠存在下，将丁基-N，N'-二酰基肼与1-（6-氯-3-吡啶甲基）-2-硝基亚氨基咪唑烷（吡虫啉）。他们的杀幼虫活性进行了评估。它们都表现出对东方粘虫和豆蚜的杀虫活性。毒性试验表明，在较高浓度下（200 mg L -1）标题化合物可在2小时内杀死杀灭蚜虫的速度与亲代吡虫啉一样快，而在较低浓度（10 mg L -1）下，标题化合物可在治疗3天后诱发幼虫，异常和致死幼虫蜕变，例如母体二酰基肼。

  DOI：

  10.1021/jf903642s
• 作为产物：
  描述：

  3,5-二甲基苯甲酸 在 sodium hydroxide 、 氯化亚砜 作用下， 以 乙醚 为溶剂， 反应 15.0h， 生成 N-tert-butyl-N'-benzoyl-N-3,5-dimethyl-benzoylhydrazine
  参考文献：
  名称：

  Quantitative structure-activity analysis of larvicidal 1-(substituted benzoyl)-2-benzoyl-1-tert-butylhydrazines againstChilo suppressalis

  摘要：

  AbstractThe larvicidal activity of a number of 1‐(substituted benzoyl)‐2‐benzoyl–1 ‐ten‐butylhydrazines against the rice stem borer (Chilo suppressalis Walk.) was measured. Variations in the activity were examined quantitatively using physico‐chemical substituent and molecular parameters and regression analysis. The results indicated that the molecular hydrophobicity and the electron‐withdrawing inductive/ field effect of ontho substituents are favourable to larvicidal activity. The bulkiness of substituents at the meta and para positions was unfavourable to activity, substitution at the para position being more unfavourable than that at the meta position in terms of van der Waals' volume. The 2,3–, 2,5‐ and 2,6‐disubstitution patterns were also unfavourable to activity. Reductions in larvicidal activity caused by the 2,6‐,‐ 2,3,5‐ and 2,3,4,5‐substitutions were greater than those induced by the 2,3‐ and 2,5‐disubstitutions. When the sum of contributions from favourable effects is greater than that from unfavourable effects, the larvicidal activity is expected to be superior to that of the unsubstituted compound.

  DOI：

  10.1002/ps.2780410210

文献信息

• Synthesis and insecticidal evaluation of novelN-(S-amino)sulfenylated derivatives of diacylhydrazines
  作者：Qingmin Wang、Junran Cheng、Runqin Huang

  DOI：10.1002/ps.597

  日期：2002.12

  the presence of sodium hydride, and evaluated for moulting hormone mimicking activity. In the course of syntheses, N-N bond cleavage in diacylhydrazines was found and the reaction was studied in some detail. The results of bioassay showed that the title compounds exhibit excellent larvicidal activity. Toxicity assays indicated that these compounds can induce a premature, abnormal and lethal larval

  在氢化钠存在下，通过S-氨基亚磺酰氯与N-叔丁基-N'-苯甲酰基-N-取代的苯甲酰肼的反应合成了一系列新的二酰基肼的N-（S-氨基）亚磺酰化衍生物。用于蜕皮激素的模仿活动。在合成过程中，发现二酰基肼中的NN键断裂，并且对该反应进行了详细的研究。生物测定的结果表明标题化合物表现出优异的杀幼虫活性。毒性试验表明，这些化合物可引起过早，异常和致命的幼虫坐骑。
• Synthesis and insecticidal evaluation ofN-tert-butyl-N′-thio[O-(1-methylthioethylimino)-N″-methylcarbamate]-N,N′-diacylhydrazines
  作者：Jian Shang、Yuxiu Liu、Runqiu Huang、Fuchun Bi、Qingmin Wang

  DOI：10.1002/hc.20360

  日期：2007.8

  A series of novel N-tert-butyl-N′-thio[O-(1-methylthioethylimino)-N″-methylcarbamate]-N,N′-diacylhydrazines were synthesized by the reaction of chlorosulfenyl[O-(1-methylthioethylimino)-N-methylcarbamate] with N-tert-butyl-N,N′-diacylhydrazine in the presence of sodium hydride. The reaction of sulfur dichloride with O-(1-methylthioethylimino)-N-methylcarbamate (Methomyl) in the presence of pyridine

  通过氯磺基[O-(1-甲硫基乙亚氨基)-N”-甲基氨基甲酸酯]-N,N'-二酰基肼的反应合成了一系列新型N-叔丁基-N'-硫代[O-(1-甲硫基乙基亚氨基)-N”-甲基氨基甲酸酯]-N,N'-二酰基肼-N-甲基氨基甲酸酯]与 N-叔丁基-N,N'-二酰基肼在氢化钠存在下。首次报道了二氯化硫与O-(1-甲硫基乙基亚氨基)-N-甲基氨基甲酸酯(灭多威)在吡啶存在下反应生成氯磺基[O-(1-甲硫基乙基亚氨基)-N-甲基氨基甲酸酯]。N-叔丁基-N'-硫代[O-(1-甲硫基乙基亚氨基)-N″-甲基氨基甲酸酯]-N,N'-二苯甲酰肼的X射线单晶衍射表明母体化合物N-叔丁基-N ,N'-二苯甲酰肼和O-(1-甲硫基乙基亚氨基)-N-甲基氨基甲酸酯通过NSN谱带结合得到产物。评价了它们对东方粘虫和蚜虫的杀幼虫活性。它们都对东方粘虫表现出优异的杀幼虫活性，其中一些表现出比亲本二酰基肼更高的杀幼虫活性。毒性试验表明，该产品在较高浓度下对
• Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
  申请人：Rohm and Haas Company

  公开号：US05424333A1

  公开（公告）日：1995-06-13

  This invention relates to the anthelmintic use of compositions containing N'-substituted-N,N'-disubstitutedhydrazines. Specifically, the invention relates to methods of controlling helminths by contacting the helminths with a compound having a nucleus of the formula ##STR1## wherein X and X' are the same or different O, S, or NR and A', B', R.sup.1 and R.sup.2 are a variety of substituents.

  本发明涉及含有N'-取代的N,N'-二取代腙类化合物的驱虫用途。具体来说，本发明涉及通过将具有以下结构式核的化合物与蠕虫接触来控制蠕虫的方法：##STR1##其中X和X'是相同或不同的O、S或NR，A'、B'、R1和R2是各种取代基。
• Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
  申请人：Rohm and Haas Company

  公开号：US05225443A1

  公开（公告）日：1993-07-06

  This invention relates to insecticidal compositions containing N-substituted-N'-substituted-N,N'-diacylhydrazines methods of using such compositions and novel insecticidal N-substituted-N'-substituted-N,N'-diacylhydrazines.

  本发明涉及含有N-取代-N'-取代-N，N'-二酰基肼的杀虫组合物，使用这种组合物的方法以及新型杀虫N-取代-N'-取代-N，N'-二酰基肼。
• Insecticidal N' substituted-N-N'-disubstituted-hydrazines
  申请人：Rohm and Haas Company

  公开号：US05117057A1

  公开（公告）日：1992-05-26

  This invention relates to insecticidal compositions containing N'-substituted-N,N'-disubstitutedhydrazines, methods of using such compositions and N'-substituted-N, N'-disubstitutedhydrazines. Specifically, the invention relates to insect growth regulating compositions, and methods of using such compositions, which include compounds having a nucleus of the formula ##STR1## where A', B', D and J are independently any atom or group of atoms; where E is a tertiary carbon containing organic radical, a haloalkyl having a total of at least four carbon and halogen atoms but not more than six halogen atoms, or a non-tertiary carbon containing non-haloalkyl organic or organometallic radical having at least five atoms other than hydrogen, oxygen and halogen, and is attached to the nitrogen shown in the formula by a carbon-to-nitrogen single bond; where one G.sub.1 is C, N, O and S, and both G.sub.2 's and the other G.sub.1 are carbon; or one G.sub.2 is S or P, and both G.sub.1 's and the other G.sub.2 are carbon; where the bonds shown as - - - are independently single or double bonds; where the A'-?-G.sub.1 and G.sub.1 -?-B' bonds are independently single bond, double bonds or aromatic bonds; where organic radical is a radical comprising at least one carbon atom, but no metal atoms; where organometallic radical is a radical containing a carbon-to-metal bond; or an agronomically acceptable salt thereof; and with the provisos discussed infra.

  本发明涉及含有N'-取代-N，N'-二取代腙的杀虫组合物，使用这种组合物和N'-取代-N，N'-二取代腙的方法。具体而言，本发明涉及昆虫生长调节剂组合物及使用这种组合物的方法，其中包括具有以下式子的核的化合物：##STR1## 其中A'，B'，D和J分别是任何原子或原子团；E是含有三级碳的有机基团，是具有至少四个碳和卤素原子总数但不超过六个卤素原子的卤代烷基，或是具有至少五个除氢，氧和卤素之外的原子的非三级碳含量的非卤代烷基有机或有机金属基团，并通过碳-氮单键连接到式中所示的氮；其中一个G.sub.1是C，N，O和S，而两个G.sub.2和另一个G.sub.1是碳；或其中一个G.sub.2是S或P，而两个G.sub.1和另一个G.sub.2是碳；其中所示的- - -键是独立的单键或双键；其中A'-?-G.sub.1和G.sub.1-?-B'键是独立的单键，双键或芳香键；有机基团是至少含有一个碳原子但不含金属原子的基团；有机金属基团是含有碳-金属键的基团；或其农业上可接受的盐；在满足下述条件的情况下。