sec-butyl 4-(dimethylamino)butanoate hydrochloride | 1532526-63-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: sec-butyl 4-(dimethylamino)butanoate hydrochloride
• 英文别名: Butan-2-yl 4-(dimethylamino)butanoate；butan-2-yl 4-(dimethylamino)butanoate
• CAS: 1532526-63-8
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.282
• InChiKey: DRVVQCWUBYEWEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (fluoromethyl)(phenyl)(2,3,4,5-tetramethylphenyl)sulfonium tetrafluoroborate 、 sec-butyl 4-(dimethylamino)butanoate hydrochloride 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 以78%的产率得到4-(sec-butoxy-N-(fluoromethyl))-N,N-dimethyl-4-oxobutan-1-aminium tetrafluoroborate
  参考文献：
  名称：

  Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications

  摘要：

  本文介绍了一种合成氟甲基化肉碱生物合成中间体（即 δ³ 丁基甜菜碱和三甲基赖氨酸的氟化衍生物）的简便方法。利用 19F NMR 和 LC-MS 分析法，氟甲基化探针可用于体外和细胞检测。

  DOI：

  10.1039/c3cc47581f
• 作为产物：
  描述：

  4-(二甲基氨基)丁酸 、 仲丁醇 在 盐酸 作用下， 以 乙醚 为溶剂， 以93%的产率得到sec-butyl 4-(dimethylamino)butanoate hydrochloride
  参考文献：
  名称：

  Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications

  摘要：

  本文介绍了一种合成氟甲基化肉碱生物合成中间体（即 δ³ 丁基甜菜碱和三甲基赖氨酸的氟化衍生物）的简便方法。利用 19F NMR 和 LC-MS 分析法，氟甲基化探针可用于体外和细胞检测。

  DOI：

  10.1039/c3cc47581f

文献信息

• POLYMER
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20180030175A1

  公开（公告）日：2018-02-01

  A polymer that is capable of affording a heat storage material superior in humidity permeability and shape retention after phase transition and that is superior in molding processability is provided. The polymer includes constitutional units (A) derived from ethylene, constitutional units (B) represented by a specified formula, and optionally includes constitutional units (C) represented by another specified formula. Where the total number of the units (A), the units (B), and the units (C) is 100%, the number of the units (A) accounts for 70% to 99%, the total number of the units (B) and the units (C) accounts for 1% by weight to 30% by weight. Where the total number of the units (B) and the units (C) is 100%, the number of the units (B) accounts for 1% to 100% and the number of the units (C) accounts for 0% to 99%.
• Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications
  作者：Anna M. Rydzik、Ivanhoe K. H. Leung、Armin Thalhammer、Grazyna T. Kochan、Timothy D. W. Claridge、Christopher J. Schofield

  DOI：10.1039/c3cc47581f

  日期：——

  A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ-butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell based assays employing 19F NMR and LC-MS analyses.

  本文介绍了一种合成氟甲基化肉碱生物合成中间体（即 δ³ 丁基甜菜碱和三甲基赖氨酸的氟化衍生物）的简便方法。利用 19F NMR 和 LC-MS 分析法，氟甲基化探针可用于体外和细胞检测。