申请人:THE TRUSTEES OF DARTMOUTH COLLEGE
公开号:US10954315B2
公开(公告)日:2021-03-23
Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.
本发明提供了能够发生可逆三维结构变形的超分子聚假轴烷水凝胶组合物和三维结构,其中包括:(a) 溶剂;(b) 至少部分为线性的聚合物,其中聚合物还包括能够在聚合物之间发生共价交联的基团;(ii) 至少一个第一大环,该环与聚合物网络中的聚合物形成假轴烷;以及 (iii) 至少一个第二大环,该环不形成假轴烷。水凝胶组合物具有一定的粘度,可用于水凝胶的三维打印以形成三维结构,交联后具有一定的储存(弹性)模量,可使三维结构在溶剂条件改变时发生可逆的三维结构变形。此外,还提供了制造组合物和三维结构的方法。