ethyl 2-acetyl-5-oxoheptanoate | 769170-27-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: ethyl 2-acetyl-5-oxoheptanoate
• 英文别名: 2-acetyl-5-oxo-heptanoic acid ethyl ester；2-Acetyl-5-oxo-heptansaeure-aethylester；Ethyl 2-acetyl-5-oxoheptanoate
• CAS: 769170-27-6
• 化学式: C₁₁H₁₈O₄
• 分子量: 214.262
• InChiKey: FWWMCKRHSXMHBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  盐酸 、 ethyl 2-acetyl-5-oxoheptanoate 、 苯 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Blaise; Maire, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1907, vol. 144, p. 572

  摘要：

  DOI：
• 作为产物：
  描述：

  1-戊烯-3-酮 、 乙酰乙酸乙酯 反应 2.0h， 以82%的产率得到ethyl 2-acetyl-5-oxoheptanoate
  参考文献：
  名称：

  An innovative strategy for electrochemically-promoted addition reactions

  摘要：

  事实证明，在无溶剂条件下，基于电解介质中支撑电解质剂的催化释放的新策略对于直接电活化适当的含 C-H 酸化合物与催化加成过程是有效的。

  DOI：

  10.1039/b406512c

文献信息

• Heterogeneous Amine Catalyst Grafted on Amorphous Silica: An Effective Organocatalyst for Microwave-promoted Michael Reaction of 1,3-Dicarbonyl Compounds in Water
  作者：Hisahiro Hagiwara、Sachiyo Inotsume、Masakazu Fukushima、Takashi Hoshi、Toshio Suzuki

  DOI：10.1246/cl.2006.926

  日期：2006.8

  Michael addition of a 1,3-dicarbonyl compound to an α,β-unsaturated carbonyl compound was effectively catalyzed by heterogeneous N,N-diethylaminopropylated silica gel (NDEAP) in water under microwave heating. The reaction condition was mild, practical, and environmentally benign. The sustainable nature of the catalyst was exemplified by re-use up to 5 times.

  在微波加热下，于水中，N,N-二乙基氨基丙基化硅胶（NDEAP）有效地催化1,3-二羰基化合物与α,β-不饱和羰基化合物的迈克尔加成反应。反应条件温和、实用且环境友好。催化剂的可持续性通过重复使用多达5次得以体现。
• Electrochemically Induced Addition Reactions in the Absence of Solvent and Supporting Electrolyte
  作者：Tonino Caruso、Marta Feroci、Achille Inesi、Monica Orsini、Arrigo Scettri、Laura Palombi

  DOI：10.1002/adsc.200606082

  日期：2006.9

  Solvent- and supporting electrolyte-free electrolysis in a two-compartment cell proved to be effective for the direct electroactivation of CH acid-containing compounds vs. catalytic addition processes. Michael adducts (including quaternary carbon centres) and 2-nitroalkanols were obtained in very good yields and selectivity on application of a catalytic amount of electricity under galvanostatic conditions

  在两室电解槽中，无溶剂和无电解质的电解被证明对含CH酸的化合物的直接电活化相对于催化加成过程是有效的。通过在恒电流条件下施加催化量的电，可以非常好的收率和选择性获得迈克尔加合物（包括季碳中心）和2-硝基链烷醇。
• Silica gel-mediated catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to highly toxic methyl vinyl ketone without volatilization
  作者：Kiyoshi Tanemura、Taoufik Rohand

  DOI：10.1016/j.tetlet.2020.152142

  日期：2020.7

  Silica gel-mediated Michael addition of 1,3-dicarbonyl compounds to methyl vinyl ketone (MVK) and ethyl vinyl ketone (EVK) was carried out to give the corresponding adducts in quite excellent yields. The reactions could be carried out without any catalysts and solvents. In addition, highly toxic MVK and EVK could be employed without significant volatilization. Silica gel could be recycled five times

  进行了硅胶介导的1,3-二羰基化合物到甲基乙烯基酮（MVK）和乙基乙烯基酮（EVK）的迈克尔加成反应，从而以相当优异的收率得到了相应的加合物。反应可以在没有任何催化剂和溶剂的情况下进行。此外，可以使用剧毒的MVK和EVK，而不会明显挥发。硅胶可以循环使用五次而不会降低产量。
• Genomic salmon testes DNA as a catalyst for Michael reactions in water
  作者：Margherita De Rosa、Sara Di Marino、Anna Maria D’Ursi、Maria Strianese、Annunziata Soriente

  DOI：10.1016/j.tet.2012.02.007

  日期：2012.4

  The DNA molecule, recognized as the carrier of genetic information in vivo, can function as an efficient organocatalyst for Michael additions of 1,3-dicarbonyl compounds to activated alkenes in aqueous media. The procedure described here is environmentally benign and offers several advantages in terms of simplicity, generality and efficiency. We have used fluorescence spectroscopy to evaluate the catalytic activity of a molecule of DNA. (C) 2012 Elsevier Ltd. All rights reserved.