ebeiedinone | 25650-68-4

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ebeiedinone
• 英文别名: eduardine；(1R,2S,6S,9S,10R,11S,14S,15S,18S,20S,23R,24S)-20-hydroxy-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosan-17-one
• CAS: 25650-68-4
• 化学式: C₂₇H₄₃NO₂
• 分子量: 413.644
• InChiKey: MWBJDDYEYGDWCZ-UWGLCIHQSA-N

物化性质

• 沸点：
  536.4±35.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 储存条件：
  2-8°C

制备方法与用途

生物活性

Ebeiedinone 是一种川贝母类固醇生物碱，在浓度为 0.1 mM 时抑制人全血胆碱酯酶 (ChE) 的生物活性，抑制率为 69.0%。

体外研究

Ebeiedinone 具有抗红细胞（RBC）乙酰胆碱酯酶（AChE）和抗血浆丁酰胆碱酯酶（BChE）的活性。

反应信息

• 作为反应物：
  描述：

  ebeiedinone 在 sodium tetrahydroborate 作用下， 以 吡啶 为溶剂， 生成 ebeiedine diacetate
  参考文献：
  名称：

  Lee, Ping; Kitamura, Yukie; Kaneko, Koh, Chemical and pharmaceutical bulletin, 1988, vol. 36, # 11, p. 4316 - 4329

  摘要：

  DOI：

文献信息

• Prederivatization and High-Performance Liquid Chromatographic Analysis of Alkaloids of Bulbs of Fritillaria
  作者：Kan Ding、Ge Lin、Yee-Ping Ho、Tin Y Cheng、Ping Li

  DOI：10.1021/js960211v

  日期：1996.11

  A method of prederivatization and HPLC with UV detection was developed for the simultaneous analysis of five major steroidal alkaloids of the Fritillaria species: verticine, verticinone, isoverticine, ebeiedine, and ebeiedinone. Derivatization was carried out by esterification of the hydroxyl-containing Fritillaria alkaloids to the corresponding naphthoates with 1-naphthoyl chloride. Reaction conditions were optimized and the yields of the derivatization were between 94 and 100% for all test alkaloids. Derivatized alkaloids were characterized by mass spectrometry and HPLC-MS. The validated HPLC-UV method demonstrated linear UV response at the sampling ranges used, and a test limit of 1 mu g/mL was determined for all analytes. This analytical method is simple, convenient, and readily reproducible. The developed method was applied to the analysis of the major pharmacologically active alkaloids in three medicinally used Fritillaria species: F. cirrhosa F. thunberghii, and F. hupehensis. Five major Fritillaria alkaloids were simultaneously analyzed qualitatively and quantitatively from crude extracts of each of these herbs.
• Lee, Ping; Kitamura, Yukie; Kaneko, Koh, Chemical and pharmaceutical bulletin, 1988, vol. 36, # 11, p. 4316 - 4329
  作者：Lee, Ping、Kitamura, Yukie、Kaneko, Koh、Shiro, Motoo、Xu, Guo-Jun、et al.

  DOI：——

  日期：——