2-(1-chloroethyl)-5-methylfuran | 917769-48-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(1-chloroethyl)-5-methylfuran
• CAS: 917769-48-3
• 化学式: C₇H₉ClO
• 分子量: 144.601
• InChiKey: ICSINTJRLBDYIY-UHFFFAOYSA-N

物化性质

• 沸点：
  141.9±25.0 °C(Predicted)
• 密度：
  1.083±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(1-chloroethyl)-5-methylfuran 、 sodium diethyl phosphite 以 苯 为溶剂， 反应 6.5h， 以45%的产率得到2-(1-diethoxyphosphorylethyl)-5-methylfuran
  参考文献：
  名称：

  2-(1-Chloroalkyl)furans in the reaction with sodium diethyl phosphite

  摘要：

  2-(1-Chloroethyl) and 2-(1-chloro-2-methylpropyl)furans react with sodium diethyl phosphite to give two products, 2-(1-diethoxyphosphorylmethyl)furan and 2-alkyl-5-(diethoxyphosphoryloxy)furan. The fraction of the latter product increases with increasing size of the alkyl radical. 2-Methyl substitution in the substrate completely suppresses phosphate formation. 2-(1-Chloroethyl)-5-(2-methylpropyl)furan under the action of sodium diethyl phosphite eliminates hydrogen chloride to give the corresponding alkene.

  DOI：

  10.1134/s1070363206040207
• 作为产物：
  描述：

  1,5-二甲基-2-呋喃甲醇 在 吡啶 、 氯化亚砜 作用下， 以 乙醚 为溶剂， 以42%的产率得到2-(1-chloroethyl)-5-methylfuran
  参考文献：
  名称：

  2-(1-Chloroalkyl)furans in the reaction with sodium diethyl phosphite

  摘要：

  2-(1-Chloroethyl) and 2-(1-chloro-2-methylpropyl)furans react with sodium diethyl phosphite to give two products, 2-(1-diethoxyphosphorylmethyl)furan and 2-alkyl-5-(diethoxyphosphoryloxy)furan. The fraction of the latter product increases with increasing size of the alkyl radical. 2-Methyl substitution in the substrate completely suppresses phosphate formation. 2-(1-Chloroethyl)-5-(2-methylpropyl)furan under the action of sodium diethyl phosphite eliminates hydrogen chloride to give the corresponding alkene.

  DOI：

  10.1134/s1070363206040207

文献信息

• 2-(1-Chloroalkyl)furans in the reaction with sodium diethyl phosphite
  作者：L. M. Pevzner

  DOI：10.1134/s1070363206040207

  日期：2006.4

  2-(1-Chloroethyl) and 2-(1-chloro-2-methylpropyl)furans react with sodium diethyl phosphite to give two products, 2-(1-diethoxyphosphorylmethyl)furan and 2-alkyl-5-(diethoxyphosphoryloxy)furan. The fraction of the latter product increases with increasing size of the alkyl radical. 2-Methyl substitution in the substrate completely suppresses phosphate formation. 2-(1-Chloroethyl)-5-(2-methylpropyl)furan under the action of sodium diethyl phosphite eliminates hydrogen chloride to give the corresponding alkene.