1-Phenoxy-cyclopropan-2-carbonsaeure-aethylester | 5362-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Phenoxy-cyclopropan-2-carbonsaeure-aethylester
• 英文别名: Ethyl 2-phenoxycyclopropane-1-carboxylate
• CAS: 5362-38-9
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: BASDBLJCLDUECB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Phenoxy-cyclopropan-2-carbonsaeure-aethylester 在 sodium hydroxide 、 三乙胺 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 反应 12.5h， 生成
  参考文献：
  名称：

  Mechanistic studies on dopamine .beta.-monooxygenase catalysis: N-dealkylation and mechanism-based inhibition by benzylic-nitrogen-containing compounds. Evidence for a single-electron-transfer mechanism

  摘要：

  DOI：

  10.1021/ja00247a033
• 作为产物：
  描述：

  重氮乙酸乙酯 、 苯基乙烯醚 在 铜 作用下， 以 xylene 为溶剂， 反应 1.0h， 以42%的产率得到1-Phenoxy-cyclopropan-2-carbonsaeure-aethylester
  参考文献：
  名称：

  Mechanistic studies on dopamine .beta.-monooxygenase catalysis: N-dealkylation and mechanism-based inhibition by benzylic-nitrogen-containing compounds. Evidence for a single-electron-transfer mechanism

  摘要：

  DOI：

  10.1021/ja00247a033

文献信息

• Synthesis of (<i>E</i>)-4-Oxo-5-hexenals and Their Acetal Derivatives
  作者：Shuji Kanemasa、Tatsuya Otsuka、Kenji Doi、Otohiko Tsuge、Eiji Wada

  DOI：10.1055/s-1990-27125

  日期：——

  An effective synthesis of (E)-4-oxo-5-hexenals 6 and the acetals 5 starting from ethyl 2-alkoxy-1-cyclopropanecarboxylates 1a-d is presented. The acid-induced ring opening of the cyclopropanecarboxylates 1a, b, followed by phosphorylmethylation or the phosphorylmethylation of the ester 1c followed by ring opening leads to the 5-acetal of 2,5-dioxopentylphosphonate 4. The Horner-Emmons olefination of 4 with various aldehydes produces the title compounds.

  本研究展示了一种从乙基2-烷氧基-1-环丙烷羧酸酯1a-d出发，合成(E)-4-氧-5-己烯醛6及其缩醛5的有效方法。首先，环丙烷羧酸酯1a、b在酸性诱导下环开裂，随后进行膦甲基化，或者先对酯1c进行膦甲基化后环开裂，得到2,5-二氧戊基膦酸酯的5-缩醛4。通过Horner-Emmons烯化反应，4与各种醛反应，生成目标化合物。
• Impact of free‐range pigs on mountain pastures in the Swiss Jura
  作者：Pascal Vittoz、Pierre Hainard

  DOI：10.1111/j.1654-109x.2002.tb00554.x

  日期：2002.12

  Abstract.The objective of this experiment was to study the impact of free‐range pigs foraging on mountain pasture vegetation. Pigs (15 week‐old, mean weight 50 kg,n= 25) were enclosed from June to mid‐September in a 2‐ha enclosure in the Jura Mountains (Switzerland) and fed with a mixture of lactoserum and cereals. The enclosure contained four different plant communities. Eutrophic pastures on deep soil were largely overturned, but recolonization was quick and vegetation dominated by the original species. Mesotrophic pastures were less damaged on stony soil but were completely destroyed on deep soil, recovery was slow and was characterized by a shift of plant species in a more eutrophic direction. Four years were not sufficient for complete recovery. Oligotrophic calcareous pastures on shallow stony soil were not damaged. The result of this study was that extensive breeding of pigs in mountain pastures are harmful to plant species in mesotrophic pastures, and should be restricted to less sensitive plant communities, with a rotation of two or three different sites.

  摘要：本实验的目的是研究散养猪觅食对山区牧草植被的影响。从 6 月到 9 月中旬，在瑞士汝拉山区的一个占地 2 公顷的圈舍中饲养了猪（15 周大，平均体重 50 公斤，n= 25 头），并喂食乳糖草和谷物混合物。围栏内有四个不同的植物群落。深层土壤上的富营养化牧场大部分被推翻，但很快又重新植被，植被以原有物种为主。石质土壤上的中营养牧场受到的破坏较小，但深层土壤上的中营养牧场则完全被毁，恢复速度缓慢，其特点是植物物种向更富营养的方向转变。四年时间不足以完全恢复。浅层石质土壤上的低营养钙质牧场没有受到破坏。这项研究的结果表明，在山地牧场大量饲养猪对中营养牧场的植物物种有害，应仅限于敏感性较低的植物群落，并在两到三个不同地点轮流饲养。
• Synthesis of Forms of a Chiral Ruthenium Complex Containing a Ru–C_olefin(sp²) Bond and Their Application to Catalytic Asymmetric Cyclopropanation Reactions
  作者：Hayato Inoue、Nga Phan Thi Thanh、Ikuhide Fujisawa、Seiji Iwasa

  DOI：10.1021/acs.orglett.0c00050

  日期：2020.2.21

  Organometallic complexes [Ru-Colefin(sp2)-Ru(II)-Pheox 2a-2d] containing a Ru-Colefin(sp2) bond have been prepared from unsaturated chiral oxazoline derivatives and evaluated for asymmetric cyclopropanation reactions. The corresponding optically active cyclopropanes were obtained with high yields and high stereoselectivities (≥99/<1 trans/cis, 99% trans ee). The enantioselectivities were found to be

  由不饱和手性恶唑啉衍生物制备了含有Ru-C烯烃（sp2）键的有机金属配合物[Ru-C烯烃（sp2）-Ru（II）-Pheox 2a-2d]，并进行了不对称环丙烷化反应的评价。以高收率和高立体选择性（≥99/ <1反式/顺式，99％反式）获得了相应的旋光性环丙烷。发现对映选择性受Ru-C（sp2）键上的双键取代基的影响。特别是，在金属上没有双键取代基的Ru（II）-Prox催化剂2c显示出最高的对映选择性。
• Julia,M.; Le Thuillier,G., Bulletin de la Societe Chimique de France, 1966, p. 717 - 728
  作者：Julia,M.、Le Thuillier,G.

  DOI：——

  日期：——
• KANEMASA, SHUJI;OTSUKA, TATSUYA;DOI, KENJI;TSUGE, OTOHIKO;WADA, EIJI, SYNTHESIS,(1990) N2, C. 1167-1169
  作者：KANEMASA, SHUJI、OTSUKA, TATSUYA、DOI, KENJI、TSUGE, OTOHIKO、WADA, EIJI

  DOI：——

  日期：——