N-[3-(2-Chloroacetamido)propyl]-2-methylprop-2-enamide | 119003-02-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[3-(2-Chloroacetamido)propyl]-2-methylprop-2-enamide
• 英文别名: N-[3-[(2-chloroacetyl)amino]propyl]-2-methylprop-2-enamide
• CAS: 119003-02-0
• 化学式: C₉H₁₅ClN₂O₂
• 分子量: 218.68
• InChiKey: VOQACZADDJDTOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(3-氨基丙基)甲基丙烯酸盐 盐酸盐 、 氯乙酰氯 、 三乙胺 、 在 ice 、 乙酸乙酯 、 三乙胺盐酸盐 、 crude monomer 、 silica gel 、 二氯甲烷 、 2,6-二叔丁基-4-甲基苯酚 作用下， 以 甲醇 、 2,6-二叔丁基-4-甲基苯酚 为溶剂， 反应 19.5h， 以to give a white crystalline compound, mp 85°-90° C., 83 g (43% yield)的产率得到N-[3-(2-Chloroacetamido)propyl]-2-methylprop-2-enamide
  参考文献：
  名称：

  Bilirubin assay using crosslinkable polymers

  摘要：

  一种用于测定生物液体中共轭或非共轭胆红素的比色测定方法，可以使用改进的分析元素进行。该元素包括一个支撑物，其上具有一个无明胶媒染层，具有至少一个与胆红素结合的正电交互媒染剂结合位点，一个辐射阻挡层和一个多孔扩散层。交互媒染剂分散在可交联共聚物的粘合剂材料中，该共聚物包括一种能够与交联剂反应以交联共聚物的单体。

  公开号：

  US05286450A1

文献信息

• Electrophoresis element comprising a polymer containing a haloacetamido
  申请人：Eastman Kodak Company

  公开号：US05212253A1

  公开（公告）日：1993-05-18

  Described are novel acrylic monomers, homopolymers and copolymers prepared therefrom, and electrophoresis gel media prepared by crosslinking certain copolymers of the invention by a crosslinking reaction that does not involve a free-radical vinyl addition mechanism.

  本文描述了一种新型的丙烯酸单体、由此制备的均聚物和共聚物，以及通过交联某些发明的共聚物制备的电泳凝胶介质，所述交联反应不涉及自由基乙烯加成机制。
• RETENTION COATINGS FOR DELIVERY SYSTEMS
  申请人：Stucke M. Sean

  公开号：US20080114451A1

  公开（公告）日：2008-05-15

  A coating composition, in both its uncrosslinked and crosslinked forms, for use in increasing the static friction of a surface of a delivery system comprising a medical device having a surface in contact with the surface of a delivery component, the static friction of the surface being increased in an amount sufficient to substantially maintain the position of the medical device on the delivery component against forces asserted on the delivery system as it navigates through a vessel of the body. The delivery system may comprise a balloon catheter as the delivery component and a stent as the medical device. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, optionally a photoderivatized monomer, and a hydrophilic monomer such as (meth)acrylamide.

  一种涂料组合物，其未交联和交联形式均可用于增加医疗设备表面与输送组件表面接触的表面的静摩擦力，增加的静摩擦力足以在输送系统通过人体血管时，对医疗设备在输送组件上的位置产生实质性的维持作用，输送系统可以包括球囊导管作为输送组件和支架作为医疗设备。该组合物包括聚醚单体，例如烷氧基聚（烷基二醇），含羧酸单体，例如（甲基）丙烯酸，可选的光衍生单体和亲水性单体，例如（甲基）丙烯酰胺。
• Kit for electrophoresis gel medium
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0340653A2

  公开（公告）日：1989-11-08

  A polyacrylamide type gel medium for electrophoresis is conveniently and safely prepared prior to use from a kit which comprises (1) a water-soluble copolymer of an acrylamide monomer and at least one comonomer copolymerizable therewith, which comonomer contains functional groups that permit crosslinking of said copolymer by a covalent but non-free radical initiated mechanism; and (2) a selected crosslinking agent in a package that separates it from the copolymer. Optionally, additional materials that may be usefully incorporated in the gel may be included in the kit, for example, a selected electrophoresis buffer and a complexing agent, such as SDS. The kit is used to prepare the gel by forming a solution of the copolymer in deionized water at the desired concentration of copolymer, adding a sufficient amount of any optional ingredients to provide the desired concentrations thereof, adding such concentration of the crosslinking agent as will provide a gelation time of between 5 minutes and 15 hours, and pouring the so prepared reaction mixture into a preselected mold or casting device or onto a support so as to form the resulting gel into the desired shape and size.

  用于电泳的聚丙烯酰胺型凝胶培养基在使用前可方便安全地从试剂盒中制备，试剂盒包括：(1) 一种丙烯酰胺单体和至少一种可与之共聚的共聚单体的水溶性共聚物，该共聚单体含有允许所述共聚物通过共价但非自由基引发机理交联的官能团；(2) 一种选定的交联剂，该交联剂与共聚物分装在一个包装中。此外，试剂盒中还可包括其他可用于凝胶的材料，例如选定的电泳缓冲液和络合剂（如 SDS）。该试剂盒用于制备凝胶，方法是在去离子水中形成所需浓度的共聚物溶液，加入足量的任选成分以提供所需浓度，加入一定浓度的交联剂以提供 5 分钟至 15 小时的凝胶化时间，然后将制备好的反应混合物倒入预先选择好的模具或浇注装置中，或倒入支撑物上，使得到的凝胶形成所需形状和大小。
• Diagnostic kit and method for rapid detection of antibodies
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0337785A1

  公开（公告）日：1989-10-18

  Diluent and wash compositions are useful in a rapid and sensitive assay for detecting antibodies, and especially retroviral antibodies, in a biological specimen. The diluent composition is buffered to a pH of 6 to 10 and includes a protein or carbohydrate, a surfactant and a negatively-charged organic compound. The wash composition is buffered to a pH of 5 to 10 and includes a surfactant. These compositions can be included in a diagnostic kit. The method of this invention includes mixing the biological specimen with the diluent composition, forming an immunological complex between ligand and antibodies in the specimen and separating complexed materials from uncomplexed materials using a filtration membrane and a washing step. An enzyme labeled anti-antibody is added to form a ligand-antibody-antibody complex followed by its detection using suitable reagents.

  稀释剂和洗涤组合物可用于快速灵敏地检测生物样本中的抗体，特别是逆转录病毒抗体。稀释剂组合物的 pH 值为 6 至 10，包括蛋白质或碳水化合物、表面活性剂和负电荷有机化合物。洗涤组合物的 pH 值为 5 至 10，包括表面活性剂。这些组合物可以包含在诊断试剂盒中。本发明的方法包括将生物标本与稀释剂组合物混合，在标本中的配体与抗体之间形成免疫复合物，并使用过滤膜和洗涤步骤将复合物与未复合物分离。加入酶标记的抗抗体以形成配体-抗体-抗体复合物，然后使用合适的试剂进行检测。
• Method for the purification of immunoreactive labeled thyroxine conjugates
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0467466A1

  公开（公告）日：1992-01-22

  A method for purifying immunoreactive labeled thyroxine conjugates using immobilied antibodies that are i) raised against an analogue of thyroxine (T4) and ii) cross-reactive with thyroxine.

  一种利用固定抗体纯化免疫反应标记甲状腺素共轭物的方法，这些抗体 i) 针对甲状腺素（T4）的类似物，ii) 与甲状腺素有交叉反应。