ethyl N-3-chloropropylaminoacetate | 823797-38-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl N-3-chloropropylaminoacetate
• 英文别名: (3-chloropropylamino)acetic acid ethyl ester；Chloropropylglycine ethyl ester；ethyl 2-(3-chloropropylamino)acetate
• CAS: 823797-38-2
• 化学式: C₇H₁₄ClNO₂
• 分子量: 179.647
• InChiKey: WQKROIUZXRQNBJ-UHFFFAOYSA-N

物化性质

• 沸点：
  238.7±25.0 °C(Predicted)
• 密度：
  1.070±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl N-3-chloropropylaminoacetate 在 盐酸 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 22.0h， 生成 N-(3-phosphonopropyl)glycine
  参考文献：
  名称：

  N-(3-Phosphonopropyl)-substituted α-amino acids and their phosphine oxide analogs

  摘要：

  基于 2-氧代-1,2-氮磷杂环戊烷和 1,2-氮磷杂环戊烷钛盐的水解，开发了一种简便的方法来合成 N-(3-膦酰丙基)取代的 α-氨基酸及其氧化膦类似物。分离出一种螯合物 CuII N-[(3-二苯基磷酰)丙基]甘氨酸。

  DOI：

  10.1007/s11172-006-0168-4
• 作为产物：
  描述：

  3-氯丙胺盐酸盐 、 溴乙酸乙酯 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 72.0h， 以54.6%的产率得到ethyl N-3-chloropropylaminoacetate
  参考文献：
  名称：

  Synthesis of 1,2-azaphospholanes containing an amino acid fragment

  摘要：

  合成了含有氨基酸片段的2-氧代-1,2-氮杂膦烷和1,2-氮杂膦盐，通过对N-3-氯丙基取代的三配位磷酰胺进行分子内P-烷基化。2-氧代-1,2-氮杂膦烷在P-N键水解后生成γ-氨基丙基磷酸衍生物。

  DOI：

  10.1007/s11172-006-0169-3

文献信息

• [EN] HETEROCYCLIC SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES SUBSTITUES PAR DES HETEROCYCLES, UTILISES COMME ANTAGONISTES DES RECEPTEURS 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005003124A1

  公开（公告）日：2005-01-13

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括这些新化合物的药用组合物以及这些化合物作为药物的用途。
• Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
  申请人：Bosmans René Marie André Jean-Paul

  公开号：US20070197600A1

  公开（公告）日：2007-08-23

  The present invention is concerned with novel compounds of formula (I) having 5HT 4 -antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的化合物(I)的新颖化合物。本发明还涉及制备这种新颖化合物的方法，含有该新颖化合物的药物组合物以及该化合物作为药物的使用。
• HETEROCYCLIC SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1638961A1

  公开（公告）日：2006-03-29
• METHOD OF PRODUCING OPTICALLY ACTIVE N-(HALOPROPYL) AMINO ACID DERIVATIVE
  申请人：Matsumoto Jun

  公开号：US20110190527A1

  公开（公告）日：2011-08-04

  The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active alanine ester represented by formula (I) or a salt thereof (hereinafter sometimes simply referred to as an “alanine ester”) with a halogenated propane represented by formula (II); and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV) by introducing a protecting group onto the nitrogen atom of the compound represented by formula (III). The present invention provides a method for efficiently producing an optically active N-(halopropyl)amino acid derivative.
• SMALL MOLECULE COMPOUNDS AS BROAD-SPECTRUM INHIBITORS OF METALLO-BETA-LACTAMASES
  申请人：Song Yongcheng

  公开号：US20120329842A1

  公开（公告）日：2012-12-27

  The present invention concerns methods and/or compositions for treatment and/or prevention of bacterial infection wherein the bacteria has at least one metallo-β-lactamase. The bacteria are provided with an inhibitor of the metallo-β-lactamase, for example in conjunction with an antibiotic that targets the bacteria. The bacteria may be a drug-resistant strain or susceptible to becoming a drug-resistant strain. In specific embodiments, the bacteria is Pseudomonas or Acinetobacter spp.