4-hydroxybutyl phenyl carbonate | 137075-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxybutyl phenyl carbonate
• CAS: 137075-28-6
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: KVZSCIGTOPVIGR-UHFFFAOYSA-N

物化性质

• 沸点：
  339.9±34.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-hydroxybutyl phenyl carbonate 在 Jones reagent 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以65%的产率得到4-(phenoxycarbonyloxy)butanoic acid
  参考文献：
  名称：

  [EN] PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF
  [FR] PROMÉDICAMENTS À BASE D'ACIDE GAMMA-HYDROXYBUTYRIQUE, COMPOSITIONS ET UTILISATIONS DE CEUX-CI

  摘要：

  本申请公开了γ-羟基丁酸的前药，以及其组合物和用途。

  公开号：

  WO2017049470A1
• 作为产物：
  描述：

  1,4-丁二醇 、 氯甲酸苯酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.17h， 以40%的产率得到4-hydroxybutyl phenyl carbonate
  参考文献：
  名称：

  [EN] PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF
  [FR] PROMÉDICAMENTS À BASE D'ACIDE GAMMA-HYDROXYBUTYRIQUE, COMPOSITIONS ET UTILISATIONS DE CEUX-CI

  摘要：

  本申请公开了γ-羟基丁酸的前药，以及其组合物和用途。

  公开号：

  WO2017049470A1

文献信息

• (cyanomethyl)pyridines useful as PAF antagonists
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0441226A1

  公开（公告）日：1991-08-14

  57 The present invention relates to new (cyanomethyl)pyridines of general formula I: wherein A is nitrogen and B is -CH-, or B is nitrogen and A is -CH-; the group Y-W- represents a group of formula N-CR1(CN)-, N-CH2-CH(CN)-, CH-CH(CN)- or C=C(CN)- wherein R1 is hydrogen or a C1-C6 alkyl group; R represents a group of formula R2CO-, R3R4N-(CH2)nCO- or R5-(CH2)m wherein R2 represents C1-C15 alkyl, aryl, aryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkenyl, diaryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkenyl, arylhydroxy-(C1-C6)-alkyl, diarylhydroxy-(Ci-C6)-alkyl, aryl-(C1-C6)-alkoxy, diaryl-(C1-C6)-alkoxy, or heteroaryl-(C1-C6)-alkyl group; n is 0, 1, 2 or 3; R3 is hydrogen, C1-C6 alkyl, aryl or aryl-(Cl-C6)-alkyl group; R4 is C3-C6 cycloalkyl, aryl, aryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkyl, aryl-(C1-C6)-alkylcarbonyl or diaryl-(C1-C6)-alkylcarbonyl group; m is 0, 1 or 2; and R5 is aryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkyl, diaryl-(C1-C6)-alkylcarbonylamino or diaryl-(C1-C6)-alkylaminocarbonyl group. These compounds are potent, orally active PAF antagonists and consequently, useful in the treatment of the diseases in which this substance is involved.

  本发明涉及一般式I的新(氰甲基)吡啶：其中A为氮，B为-CH-，或者B为氮，A为-CH-；基团Y-W-表示一种具有以下式N-CR1(CN)-、N-CH2-CH(CN)-、CH-CH(CN)-或C=C(CN)-的基团，其中R1为氢或C1-C6烷基；R表示一种具有以下式R2CO-、R3R4N-(CH2)nCO-或R5-(CH2)m的基团，其中R2表示C1-C15烷基、芳基、芳基-(C1-C6)-烷基、芳基-(C1-C6)-烯基、二芳基-(C1-C6)-烷基、二芳基-(C1-C6)-烯基、芳基羟基-(C1-C6)-烷基、二芳基羟基-(Ci-C6)-烷基、芳基-(C1-C6)-氧基、二芳基-(C1-C6)-氧基或杂芳基-(C1-C6)-烷基；n为0、1、2或3；R3为氢、C1-C6烷基、芳基或芳基-(Cl-C6)-烷基；R4为C3-C6环烷基、芳基、芳基-(C1-C6)-烷基、二芳基-(C1-C6)-烷基、芳基-(C1-C6)-烷基羰基或二芳基-(C1-C6)-烷基羰基；m为0、1或2；R5为芳基-(C1-C6)-烷基、二芳基-(C1-C6)-烷基、二芳基-(C1-C6)-烷基羰胺基或二芳基-(C1-C6)-烷基氨基羰基基团。这些化合物是有效的口服PAF拮抗剂，因此，在这种物质参与的疾病治疗中非常有用。
• A lanthanide MOF catalyst with an excellent thermal stability for the synthesis of polycarbonate diol
  作者：Liping Wang、Jiao He、Xueying Chen、Yanling Lv

  DOI：10.1007/s13738-020-01929-8

  日期：2020.9

  68 nm, respectively. As a heterogeneous Lewis acid catalyst, the activity of Yb(BTC) for the synthesis of polycarbonate diol (PCDL) via transesterification between diphenyl carbonate and diol was investigated. Compared with nine reported catalysts, Yb(BTC) exhibits the highest catalytic activity for the synthesis of PCDL.

  A lanthanide metal–organic framework (MOF) Yb(BTC)(H2O)·(DMF) (BTC = 1,3,5-benzenetricarboxylate, DMF = N,N-dimethylformamide) was prepared from Yb(NO3)3·5H2O and H3BTC using the solvothermal method and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, N2 adsorption–desorption technology, and temperature-programmed
• Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
  申请人：XW LABORATORIES INC.

  公开号：US10457627B2

  公开（公告）日：2019-10-29

  The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.

  本公开披露了γ-羟丁酸的原药及其组合物和用途。
• PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF
  申请人：XW Laboratories Inc.

  公开号：EP3353145A1

  公开（公告）日：2018-08-01
• [EN] PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF<br/>[FR] PROMÉDICAMENTS DE L'ACIDE GAMMA-HYDROXYBUTYRIQUE, COMPOSITIONS ET UTILISATIONS DE CEUX-CI
  申请人：XW LAB INC

  公开号：WO2017050259A1

  公开（公告）日：2017-03-30

  Provided are prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.