9H-Carbazole-1-sulfonic acid | 64078-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9H-Carbazole-1-sulfonic acid
• CAS: 64078-74-6
• 化学式: C₁₂H₉NO₃S
• 分子量: 247.27
• InChiKey: WTZQJWITZKKMAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] LANTHIONINE C-LIKE PROTEIN 2 LIGANDS, CELLS PREPARED THEREWITH, AND THERAPIES USING SAME<br/>[FR] LIGANDS DE LA PROTÉINE 2 DE TYPE LANTHIONINE C, CELLULES PRÉPARÉES AVEC CEUX-CI, ET THÉRAPIES LES UTILISANT
  申请人：LANDOS BIOPHARMA INC

  公开号：WO2021127472A1

  公开（公告）日：2021-06-24

  Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including autoimmune diseases, inflammatory diseases, chronic inflammatory diseases, diabetes, and infectious diseases, such as lupus, rheumatoid arthritis, type 1 diabetes, inflammatory bowel disease, viral diseases, and nonalcoholic steatohepatitis. The compounds can also be used to generate cells, such as immune cells, for treating the conditions.

  提供的是靶向兰硫氨酸合成酶C样蛋白2途径的化合物。这些化合物可用于治疗多种疾病，包括自身免疫性疾病、炎症性疾病、慢性炎症性疾病、糖尿病和传染性疾病，如狼疮、类风湿性关节炎、1型糖尿病、炎症性肠病、病毒性疾病和非酒精性脂肪肝炎。这些化合物还可用于生成细胞，如免疫细胞，以治疗这些疾病。
• [EN] PLXDC2 LIGANDS<br/>[FR] LIGANDS DE PLXDC2
  申请人：LANDOS BIOPHARMA INC

  公开号：WO2021195360A1

  公开（公告）日：2021-09-30

  Provided are compounds that target plexin domain containing 2 (PLXDC2). The compounds can be used to treat conditions such as inflammatory or immune-mediated diseases, diabetes, infectious diseases, and cancers. The compounds can be used to treat such specific conditions as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, autoimmune encephalitis, diabetic nephropathy, diabetic retinopathy, psoriasis, and inflammatory bowel disease, among other conditions.

  提供了针对含有plexin结构域2（PLXDC2）的化合物。这些化合物可以用于治疗炎症或免疫介导性疾病、糖尿病、传染病和癌症等疾病。这些化合物可以用于治疗系统性红斑狼疮、类风湿关节炎、多发性硬化症、自身免疫性脑炎、糖尿病肾病、糖尿病视网膜病变、银屑病和炎症性肠病等特定疾病。
• Verflüssigungsmittel für mineralische Bindemittel
  申请人：RÜTGERSWERKE AKTIENGESELLSCHAFT

  公开号：EP0291644A2

  公开（公告）日：1988-11-23

  Die Erfindung betrifft neue Verflüssigungsmittel für mineralische Bindemittel auf Basis von wasserlöslichen Kondensationsprodukten von Naphthalin oder Alkylnaphthalinen mit Formaldehyd. Sie sind dadurch gekennzeichnet, daß die Kondensationsprodukte cokondensiertes sulfoniertes Carbazol enthalten.

  本发明涉及基于萘或烷基萘与甲醛的水溶性缩合产物的新型矿物粘合剂。 它们的特点是缩合产物中含有缩合磺化咔唑。
• Friction material having heat-resistant paper support bearing resin-bonded carbon particles
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0515047A2

  公开（公告）日：1992-11-25

  A friction member which is suitable for use as a friction facing member in a transmission is provided. The friction member includes a uniform density heat resistant paper, a first layer of thermoset polymeric binder coated over and at least partially impregnated into one major surface of the paper, granular carbon friction particles uniformly distributed over and partially imbedded in the exposed surface of the first layer and a second layer of thermoset binder over the first layer and partially imbedded granular friction particles which coats without obscuring the granular friction particles. The friction member is made by applying a coating of liquid thermosettable binder filled with carbon particles to one major surface of the paper, supporting the coated paper and a movable carrier, applying a uniform layer of carbon friction particles over the binder layer, at least partially curing the binder layer, applying a second coating of thermosettable binder material over the carbon particles and curing the coatings until the binder material is thermoset.

  本文提供了一种适合用作变速器摩擦面部件的摩擦部件。摩擦件包括密度均匀的耐热纸、涂覆在纸的一个主要表面上并至少部分浸渍在纸的一个主要表面上的第一层热固性聚合粘合剂、均匀分布在第一层暴露表面上并部分浸渍在第一层暴露表面上的颗粒状碳摩擦颗粒，以及涂覆在第一层和部分浸渍的颗粒状摩擦颗粒上的第二层热固性粘合剂，该粘合剂涂覆在颗粒状摩擦颗粒上而不遮盖颗粒状摩擦颗粒。摩擦件的制作方法是：在纸的一个主要表面涂上一层充满碳颗粒的液态热固性粘结剂，支撑涂有粘结剂的纸和一个可移动的载体，在粘结剂层上涂上一层均匀的碳摩擦颗粒，至少部分固化粘结剂层，在碳颗粒上涂上第二层热固性粘结剂材料，固化涂层直到粘结剂材料热固性为止。
• AZAINDOLE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
  申请人：Shionogi Co., Ltd.

  公开号：EP1911759A1

  公开（公告）日：2008-04-16

  The present invention creates an azaindole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further providing a therapeutic agent for treating allergic diseases. A compound of the general formula (I) wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a 3- to 8-membered nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of -X1=X2-X3=X4- is a formula of -C(R1)=C(R2)-C(R3)=N- etc.; R1, R2, R3, R4 and R5 are independently a hydrogen atom or a halogen atom etc.; R6 is optionally substituted C1-C6 alkyloxy etc.; R7 is independently a halogen atom etc.; R8 is optionally substituted C1-C6 alky etc.; R9 is carboxy etc.; M is sulfonyl etc.; Y is a single bond etc.; L1, L2 and L3 are a single bond or alkylene optionally containing one or two heteroatoms etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or hydrate thereof.

  本发明创造了一种具有 DP 受体拮抗活性的氮杂环吲哚衍生物和一种包含上述化合物作为活性成分的药物组合物，并进一步提供了一种治疗过敏性疾病的治疗剂。 通式（I）的化合物 其中环 A 是芳香碳环等；环 B 是 3 至 8 元含氮非芳香杂环等；式中 -X1=X2-X3=X4- 是 -C(R1)=C(R2)-C(R3)=N- 等；R1、R2、R3、R4 和 R5 独立地是氢原子或卤原子等；R6 是任选取代的 C1-C6 烷氧基等。R7独立地为卤原子等；R8为任选取代的C1-C6烷基等；R9为羧基等；M为磺酰基等；Y为单键等；L1、L2和L3为单键或任选含有一个或两个杂原子的亚烷基等；n为0等；q为0等；其药学上可接受的盐或水合物。