2-(carboxymethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid | 51318-98-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(carboxymethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
• 英文别名: (2-carboxy-norborn-5-en-2-yl)-acetic acid；2.5-Methylen-1-carboxy-Δ³-cyclohexenylessigsaeure；2.5-Methylen-cyclohexen-(3)-carbonsaeure-(1)-essigsaeure-(1)；Bicyclo-[1.2.2]-hepten-(5)-carbonsaeure-(2)-essigsaeure-(2)；(2-Carboxy-norborn-5-en-2-yl)-essigsaeure；2-carboxy-5-norbornene-2-acetic acid
• CAS: 51318-98-0
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: YZGFGXBZXHCJPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-(carboxymethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 在 三甲基硅烷化重氮甲烷 作用下， 生成 methyl (1S,2S,4S)-2-(2-methoxy-2-oxoethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate 、 methyl (1R,2S,4R)-2-(2-methoxy-2-oxoethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylate
  参考文献：
  名称：

  环戊烷二羧酸和三羧酸作为角鲨烯合酶抑制剂：合成和评估。

  摘要：

  基于较早的角鲨烯合酶铅A-87049（3）和zaragozic酸，合成了一系列环戊二酸和三羧酸，并对该酶进行了评估。一些具有良好的效力，SAR揭示了这些合成抑制剂的构象和取代模式的重要性。

  DOI：

  10.1016/s0960-894x(98)00143-7
• 作为产物：
  描述：

  衣康酸 、 环戊二烯 在 对苯二酚 作用下， 以 水 、 异丙醇 为溶剂， 生成 2-(carboxymethyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
  参考文献：
  名称：

  Heterocyclic spiro compounds

  摘要：

  属于螺环[去甲基环戊烷-2,3'-哌啶]、螺环[双环[2.2.2]辛烷-2,3'-哌啶]和相应的未在环氮原子上取代或被中性或碱性基团取代的螺环吡咯烷衍生物，以及这些新化合物的药学上可接受的酸盐具有宝贵的药理学特性，并且是制药组合物的活性成分。特别是，这些新化合物具有抗病毒活性。具体实施例包括(1RS,2RS,4SR)-螺环[去甲基环戊烷-2,3'-哌啶]-盐酸盐和1'-[2-(2-氮杂螺[5.5]十一烷-2-基)-乙基]-螺环[双环[2.2.2]辛烷-2,3'-哌啶]-二盐酸盐。

  公开号：

  US04015007A1

文献信息

• BASIC COMPOUND, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND PATTERNING PROCESS
  申请人：Hatakeyama Jun

  公开号：US20120141938A1

  公开（公告）日：2012-06-07

  A chemically amplified resist composition comprising a base polymer, an acid generator, and an amine quencher in the form of a β-alanine, γ-aminobutyric acid or 5-aminovaleric acid derivative having an acid labile group-substituted carboxyl group has a high contrast of alkaline dissolution rate before and after exposure and forms a pattern of good profile at a high resolution, minimal roughness and wide focus margin.

  一种化学放大型光刻胶组合物，包括基础聚合物、酸发生剂和胺淬灭剂，后者为β-丙氨酸、γ-氨基丁酸或5-氨基戊酸的衍生物，具有一个被酸不稳定基团所取代的羧基，这种组合物在曝光前后具有高对比度的碱性溶解速率，并且能够形成高分辨率、最小粗糙度和宽焦深度的良好图案轮廓。
• Functional norbornanyl ester derivatives, polymers and process for preparing same
  申请人：Yu Hui

  公开号：US20130317156A1

  公开（公告）日：2013-11-28

  This invention relates to the new functional norbornanyl ester derivative and/or polymer compositions which are easily obtainable by reacting the Diels-Alder adduct of appropriate dienes and dienophiles with carboxylic acids. In particular, this invention relates to a new process for making cyclic chemical raw materials suitable for production coating, ink, adhesive, plasticizer, thermoplastic or thermosetting plastic and functional polymers.

  本发明涉及一种新的功能性诺博南酯衍生物和/或聚合物组合物，该组合物通过将适当的二烯和二烯丙基与羧酸反应得到。特别是，本发明涉及一种新的制备环状化学原料的方法，适用于生产涂料、油墨、粘合剂、增塑剂、热塑性或热固性塑料和功能性聚合物。
• Norbornene-based ring-opening polymerization polymer, product of hydrogenation of norbornene-based ring-opening polymerization polymer, and processes for producing these
  申请人：Taguchi Kazunori

  公开号：US20050148746A1

  公开（公告）日：2005-07-07

  A norbornene ring-opened polymer which in the molecule has repeating units represented by the formula (1): wherein R 1 represents Q, R 2 represents Q or C(═O)R 5 , R 3 represents Q or C(═O)R 6 , and R 4 represents Q or X—C(═O)R 7 (wherein Q represents hydrogen, a C 1-10 hydrocarbon group, etc.; R 5 , R 6 and R 7 each represents hydroxyl, C 1-10 alkoxyl, etc., provided that R 6 and R 7 may be bonded to each other to constitute oxygen, NH, etc.; X represents methylene, etc., provided that when R 2 is Q, then R 3 is C(═O)R 6 and R 4 is X—C(═O)R 7 and that when R 4 is Q, then R 2 is C(═O)R 5 , R 3 is C(═O)R 6 , and the configuration of R 2 and R 3 is trans, and m is 0 or 1), the polymer having a weight-average molecular weight as determined by gel permeation chromatography of 1,000 to 1,000,000. Also provided is a hydrogenation product of the norbornene ring-opened polymer. The norbornene ring-opened polymer and the hydrogenation product are excellent in heat resistance, electrical properties, etc.

  分子中具有由公式（1）表示的重复单元的去氢萘环开环聚合物：其中R1表示Q，R2表示Q或C（═O）R5，R3表示Q或C（═O）R6，R4表示Q或X—C（═O）R7（其中Q表示氢，C1-10烃基等；R5，R6和R7分别表示羟基，C1-10烷氧基等，但是当R6和R7结合形成氧，NH等时除外；X表示亚甲基等，但是当R2为Q时，R3为C（═O）R6，R4为X—C（═O）R7，当R4为Q时，R2为C（═O）R5，R3为C（═O）R6，并且R2和R3的构型为反式，m为0或1），该聚合物的重均分子量由凝胶渗透色谱法确定为1,000至1,000,000。还提供了去氢萘环开环聚合物的氢化产物。去氢萘环开环聚合物和氢化产物在耐热性，电学性能等方面表现出色。
• RESIN COMPOSITION AND SEMICONDUCTOR DEVICE BOARD
  申请人：Osaku Yumi

  公开号：US20140087136A1

  公开（公告）日：2014-03-27

  A resin composition which contains a binder resin (A), radiation-sensitive compound (B), silane-modified resin (C), and antioxidant (D), wherein a content of the silane-modified resin (C) is 0.1 to 150 parts by weight with respect to 100 parts by weight of the binder resin (A), a content of the antioxidant (D) is 0.1 to 10 parts by weight with respect to 100 parts by weight of the binder resin (A), and an amount of warping is 14 μm or less when using the resin composition to form a thickness 2 to 3 μm resin film and baking the formed resin film at 230° C. is provided.

  一种树脂组合物，包含粘合剂树脂（A），辐射敏感化合物（B），硅改性树脂（C）和抗氧化剂（D），其中硅改性树脂（C）的含量相对于100份粘合剂树脂（A）为0.1至150份重量，抗氧化剂（D）的含量相对于100份粘合剂树脂（A）为0.1至10份重量，并且使用该树脂组合物形成2至3μm厚度的树脂膜并在230°C下烘烤形成的树脂膜翘曲量为14μm或以下。
• Flame-retardant rubber composition and flame-retardant elastomer
  申请人：JSR Corporation

  公开号：EP1191061A1

  公开（公告）日：2002-03-27

  The invention provides a flame-retardant rubber composition which may form a vulcanizate of an elastomer whose deterioration of mechanical strength is little to enjoy excellent mechanical properties, even when a nonhalogenated flame retardant is contained in a high proportion in the composition, and a flame-retardant elastomer obtained therefrom. The flame-retardant rubber composition contains (A) an olefin copolymer having a functional group, which comprises (a-1) a structural unit derived from ethylene, (a-2) a structural unit derived from an α-olefin compound having 3 to 10 carbon atoms, (a-3) a structural unit derived from a functional group-containing unsaturated compound, and optionally (a-4) a structural unit derived from a nonconjugated diene compound, and has an intrinsic viscosity [η] of 0.1 to 10 dL/g as measured in decalin at 135°C, (B) a vulcanizing agent and/or a crosslinking agent and (C) a nonhalogenated flame retardant. The flame-retardant elastomer is obtained by subjecting the flame-retardant rubber composition to a vulcanizing treatment.

  本发明提供了一种阻燃橡胶组合物，该组合物即使在组合物中含有高比例的非卤化阻燃剂时，也可形成机械强度几乎不会降低的弹性体硫化物，从而享有优异的机械性能，本发明还提供了由此获得的阻燃弹性体。 阻燃橡胶组合物含有 (A) 具有官能团的烯烃共聚物，它包括 (a-1) 源自乙烯的结构单元，(a-2) 源自具有 3 至 10 个碳原子的 α 烯烃化合物的结构单元，(a-3) 源自含官能团不饱和化合物的结构单元，以及可选的 (a-4) 源自非共轭二烯化合物的结构单元。(B) 硫化剂和/或交联剂，以及 (C) 非卤化阻燃剂。阻燃弹性体是通过对阻燃橡胶组合物进行硫化处理而获得的。