N-cyclopentyl-4-chloro-benzenesulfonamide | 349403-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclopentyl-4-chloro-benzenesulfonamide
• 英文别名: 4-chloro-N-cyclopentylbenzenesulfonamide
• CAS: 349403-79-8
• 化学式: C₁₁H₁₄ClNO₂S
• mdl: MFCD00707304
• 分子量: 259.757
• InChiKey: TZIJEZNCKUQLPW-UHFFFAOYSA-N

物化性质

• 熔点：
  79-81 °C
• 沸点：
  384.5±44.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-cyclopentyl-4-chloro-benzenesulfonamide 、 4-氰基-2-氟苄溴 生成 4-chloro-N-(4-cyano-2-fluorobenzyl)-N-cyclopentylbenzenesulfonamide
  参考文献：
  名称：

  Novel Sulfonamides

  摘要：

  这项发明通常涉及发现含有磺酰胺的化合物，这些化合物是γ-分泌酶的抑制剂。

  公开号：

  US20140243374A1
• 作为产物：
  描述：

  4-氯苯磺酰胺 、 环戊烯 在 silica gel supported triflic acid 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以86%的产率得到N-cyclopentyl-4-chloro-benzenesulfonamide
  参考文献：
  名称：

  The hydroamination of alkenes with sulfonamides catalyzed by the recyclable silica gel supported triflic acid

  摘要：

  The vast applications of triflic acid (TfOH) in catalysis are severely limited by its corrosive and fuming properties. Immobilization of TfOH on silica gel well solves these problems and affords efficient recovery and reusability of TfOH. Two types of supported TfOH, the prepared silica gel supported TfOH and the in situ silica gel adsorbed TfOH, both exhibit good catalytic activity and reusability in the hydroamination of alkene with sulfonamide. The in situ silica gel adsorbed catalyst has been used for 5 runs with maintained reactivities and yields, which are superior to the performance of the prepared silica gel supported TfOH. For a series of alkenes and various sulfonamides, the heterogeneous hydroamination reactions catalyzed by both types of silica gel supported TfOH to afford similar moderate to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.025

文献信息

• [EN] NOVEL SULFONAMIDES<br/>[FR] NOUVEAUX SULFONAMIDES
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2013052700A1

  公开（公告）日：2013-04-11

  This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of γ-secretase.

  这项发明通常涉及发现含有磺胺基的化合物，这些化合物是γ-分泌酶的抑制剂。
• [EN] ALPHA-(N-BENZENESULFONAMIDO)CYCLOALKYL DERIVATIVES<br/>[FR] DÉRIVÉS ALPHA-(N-BENZÈNESULFONAMIDO)CYCLOALKYLIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010108067A1

  公开（公告）日：2010-09-23

  Disclosed are compounds, pharmaceutical compositions containing the compounds, methods for using the compounds and processes for making the compounds. More specifically, the disclosure relates to alpha-(N-benzenesulfonamido)cycloalkyl compounds that may inhibit one or both of: (i) the functioning of a γ-secretase enzyme; or (ii) the production of -amyloid. Such compounds may be beneficial in the treatment of Alzheimer's disease and other conditions. Representative compounds have the following formula (I) wherein: A, R1, and R2 are described herein.
• The hydroamination of alkenes with sulfonamides catalyzed by the recyclable silica gel supported triflic acid
  作者：Pei Nian Liu、Fei Xia、Zheng Le Zhao、Qing Wei Wang、Yu Jie Ren

  DOI：10.1016/j.tetlet.2011.09.025

  日期：2011.11

  The vast applications of triflic acid (TfOH) in catalysis are severely limited by its corrosive and fuming properties. Immobilization of TfOH on silica gel well solves these problems and affords efficient recovery and reusability of TfOH. Two types of supported TfOH, the prepared silica gel supported TfOH and the in situ silica gel adsorbed TfOH, both exhibit good catalytic activity and reusability in the hydroamination of alkene with sulfonamide. The in situ silica gel adsorbed catalyst has been used for 5 runs with maintained reactivities and yields, which are superior to the performance of the prepared silica gel supported TfOH. For a series of alkenes and various sulfonamides, the heterogeneous hydroamination reactions catalyzed by both types of silica gel supported TfOH to afford similar moderate to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.
• Novel Sulfonamides
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20140243374A1

  公开（公告）日：2014-08-28

  This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of γ-secretase.

  这项发明通常涉及发现含有磺酰胺的化合物，这些化合物是γ-分泌酶的抑制剂。