4-(1-Cyclopentylethyl)-1,2-dimethoxybenzene | 1221406-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1-Cyclopentylethyl)-1,2-dimethoxybenzene
• CAS: 1221406-67-2
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: BPGCJGYURLAWPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环戊烯 、 3,4-二甲氧基苯乙酮 在 四氟硼酸-二乙醚络合物 、 [(C₆H₆)(PCy₃)(CO)RuH]⁺*BF₄⁻ 、 氢气 作用下， 以 氯苯 为溶剂， 110.0 ℃ 、202.66 kPa 条件下， 反应 15.0h， 以45%的产率得到4-(1-Cyclopentylethyl)-1,2-dimethoxybenzene
  参考文献：
  名称：

  Intermolecular Dehydrative Coupling Reaction of Aryl Ketones with Cyclic Alkenes Catalyzed by a Well-Defined Cationic Ruthenium−Hydride Complex: A Novel Ketone Olefination Method via Vinyl C−H Bond Activation

  摘要：

  The cationic ruthenium hydride complex[(eta(6)-C(6)H(6))-(PCy(3))(CO)RuH](+)BF(4)(-) was found to be a highly effective catalyst for the intermolecular olefination reaction of aryl ketones with cycloalkenes. The preliminary mechanistic analysis revealed that an electrophilic ruthenium vinyl complex is the key species fir mediating both vinyl C-H bond activation and the dehydrative olefination steps of the coupling reaction.

  DOI：

  10.1021/om100051h

文献信息

• Intermolecular Dehydrative Coupling Reaction of Aryl Ketones with Cyclic Alkenes Catalyzed by a Well-Defined Cationic Ruthenium−Hydride Complex: A Novel Ketone Olefination Method via Vinyl C−H Bond Activation
  作者：Chae S. Yi、Do W. Lee

  DOI：10.1021/om100051h

  日期：2010.4.26

  The cationic ruthenium hydride complex[(eta(6)-C(6)H(6))-(PCy(3))(CO)RuH](+)BF(4)(-) was found to be a highly effective catalyst for the intermolecular olefination reaction of aryl ketones with cycloalkenes. The preliminary mechanistic analysis revealed that an electrophilic ruthenium vinyl complex is the key species fir mediating both vinyl C-H bond activation and the dehydrative olefination steps of the coupling reaction.