formic acid 1-ethoxy-propyl ester | 33931-57-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: formic acid 1-ethoxy-propyl ester
• 英文别名: 1-Aethoxy-propylformiat；1-Ethoxypropyl formate
• CAS: 33931-57-6
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: SAJZCCASPVEZGW-UHFFFAOYSA-N

物化性质

• 沸点：
  138.1±23.0 °C(Predicted)
• 密度：
  0.957±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  α-chloropropyl ethyl ether 、 sodium formate 以60%的产率得到formic acid 1-ethoxy-propyl ester
  参考文献：
  名称：

  Pihlaja, Kalevi; Lampi, Aija, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1986, vol. 40, # 3, p. 196 - 199

  摘要：

  DOI：

文献信息

• Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0587311A1

  公开（公告）日：1994-03-16

  Compounds of formula (I) : [wherein: R¹ is hydrogen, alkyl, aralkyl, -CORa, -CORb, -CSRa, -CSRb, -SO₂Rb, -CONHRb, -CSNHRb, -CONRbRb or -CSNRbRb; R² is hydrogen or alkyl; R³ is hydrogen, alkylidene, substituted alkyl, or Rb; R⁴ is optionally substituted alkyl, cycloalkyl, or aryl; R⁵ is RbO-, RbRbN-, RbHN-, aralkyloxycarbonyloxy or aralkyloxycarbonylamino, or R⁵ is -(CH₂)p-D-(CH₂)r- [where D is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and p and r are each 0 or an integer from 1 to 5]; A is -(CH₂)m-B-(CH₂)n- [where B is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and m and n are each 0 or an integer from 1 to 5]; Ra is alkoxy, aralkyloxy, aryloxy or alkoxycarbonyl; Rb is optionally substituted alkyl, cycloalkyl, heterocyclic, aryl or arylalkenyl]; and pharmaceutically acceptable salts and esters thereof and pro-drugs therefor, have the ability to inhibit the activity of HIV protease and may thus be used for the treatment and prophylaxis of AIDS.

  化合物的化学式为(I)：[其中：R¹为氢，烷基，芳基烷基，-CORa，-CORb，-CSRa，-CSRb，-SO₂Rb，-CONHRb，-CSNHRb，-CONRbRb或-CSNRbRb；R²为氢或烷基；R³为氢，烷基亚甲基，取代烷基或Rb；R⁴为可选取代的烷基，环烷基或芳基；R⁵为RbO-，RbRbN-，RbHN-，芳基烷氧羰氧基氧或芳基烷氧羰氨基，或R⁵为-(CH₂)p-D-(CH₂)r- [其中D为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；p和r分别为0或1到5的整数]；A为-(CH₂)m-B-(CH₂)n- [其中B为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；m和n分别为0或1到5的整数]；Ra为烷氧基，芳基烷氧基，芳氧基或烷氧羰基；Rb为可选取代的烷基，环烷基，杂环，芳基或芳基烷烯基]；以及其药学上可接受的盐和酯以及其前药，具有抑制HIV蛋白酶活性的能力，因此可用于治疗和预防艾滋病。
• 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
  申请人：Schiemann Kai

  公开号：US20110237583A1

  公开（公告）日：2011-09-29

  The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

  本发明涉及公式（I）的吡啶嘧啶衍生物作为自体税脂酶抑制剂，以及使用这些化合物治疗和/或预防由于溶血磷酸酸水平增加和/或自体税脂酶的激活引起、介导和/或传播的生理和/或病理生理状况，特别是不同癌症。
• Sulfonium salt and use thereof
  申请人：——

  公开号：US20030148211A1

  公开（公告）日：2003-08-07

  The present invention provides a sulfonium salt represented by the following formula (I): 1 wherein Q 1 , Q 2 and Q 3 each independently represent hydrogen, hydroxy, alkyl having 1 to 6 carbon atoms, or alkoxy having 1 to 6 carbon atoms, but all of Q 1 , Q 2 and Q 3 are not the same; and Q 4 and Q 5 each independently represent perfluoroalkyl having 1 to 8 carbon atoms. The present invention also provides a chemical amplifying type positive resist composition comprising said sulfonium salt above and a resin which contains a structural unit having a group that is unstable to acid and which is insoluble or slightly soluble by itself in an aqueous alkali, but becomes soluble in the aqueous alkali by an action of acid. The present invention further provides a polymerization initiator composition comprising said sulfonium salt above and a sensitizer.

  本发明提供了由下式(I)代表的锍盐： 1 其中 Q 1 , Q 2 和 Q 3 各自独立地代表氢、羟基、具有 1 至 6 个碳原子的烷基或具有 1 至 6 个碳原子的烷氧基，但所有 Q 1 , Q 2 和 Q 3 不相同；而 Q 4 和 Q 5 各自独立地代表具有 1 至 8 个碳原子的全氟烷基。 本发明还提供了一种化学放大型正抗蚀剂组合物，该组合物包含上述锍盐和一种树脂，该树脂含有一种结构单元，该结构单元具有对酸不稳定的基团，其本身不溶于或微溶于水碱，但在酸的作用下可溶于水碱。 本发明进一步提供了一种聚合引发剂组合物，该组合物包含上述锍盐和敏化剂。
• Scheeren,J.W.; Nivard,R.J.F., Recueil des Travaux Chimiques des Pays-Bas, 1971, vol. 90, p. 974 - 983
  作者：Scheeren,J.W.、Nivard,R.J.F.

  DOI：——

  日期：——
• 2,5-DIAMINO-SUBSTITUTED PYRIDO[4, 3-d]PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
  申请人：Merck Patent GmbH

  公开号：EP2352732B1

  公开（公告）日：2013-02-20