2-methyl-5-(4-nitrophenyl)furan | 60456-78-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-5-(4-nitrophenyl)furan
• CAS: 60456-78-2
• 化学式: C₁₁H₉NO₃
• 分子量: 203.197
• InChiKey: ISBHZHQARAFLGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 在 正丁基锂 、 丙酸 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 26.0h， 生成 2-methyl-5-(4-nitrophenyl)furan
  参考文献：
  名称：

  2,5-Disubstituted furans from 1,4-alkynediols

  摘要：

  1-4-Alkynediols serve as readily available starting materials for isomerisation to 1,4-diketones, which can be converted in situ into the corresponding furans by acid-catalysed dehydration. A range of 2,5-disubstituted furans was prepared using the ruthenium-based catalyst Ru(PPh3)(3)(CO)H-2 with Xantphos at 1 mol % loading. (C) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2007.05.069

文献信息

• C-H Arylation of <i>N</i> -Heteroarenes under Metal-Free Conditions and its Application towards the Synthesis of Pentabromo- and Pentachloropseudilins
  作者：Mukesh Kumar、Shweta Sharma、Parijat Sil、Manoj Kushwaha、Satyajit Mayor、Ram A. Vishwakarma、Parvinder Pal Singh

  DOI：10.1002/ejoc.201900353

  日期：2019.6.16

  Herein, we have developed a metal‐free and mild condition for the synthesis of 2‐arylated heteroarenes. The complex forming property and charge transfer property of phenothiazine expanded its application towards catalysis The optimized condition has been successfully employed for the synthesis important marine natural product namely pentabromo/chloropseudilins (PBP/PCP). The synthesized Pentachloropseudilin

  在此，我们已经开发出了无金属的温和条件，可以合成2-芳基杂芳烃。吩噻嗪的复杂的形成性质和电荷转移性质将其扩展到催化领域。优化的条件已成功用于合成重要的海洋天然产物五溴/氯假单胞菌素（PBP / PCP）。合成的五氯伪尿素（PCP）已显示出Myosin1c耗竭效应的表型，这为将PCP用作细胞中Myosin 1功能的特异性探针提供了有力的依据。
• Merging visible-light photoredox and micellar catalysis: arylation reactions with anilines nitrosated <i>in situ</i>
  作者：Mei-jie Bu、Guo-ping Lu、Jianzhong Jiang、Chun Cai

  DOI：10.1039/c8cy01221k

  日期：——

  utilized as the photocatalyst, and Triton X-100 was employed as the surfactant; both are inexpensive and commercially available. This clean and energy-saving catalytic system enables photocatalytic reactions of the diazonium ion generated in situ to proceed smoothly in water without any co-solvents or additives at room temperature.

  通过将可见光光氧化还原催化与胶束催化结合来设计水性光催化系统。使用曙红B（一种有机染料）作为光催化剂，并使用Triton X-100作为表面活性剂。两者都很便宜并且可商购。这种清洁节能的催化系统使原位产生的重氮离子在室温下无需任何助溶剂或添加剂的情况下，即可在水中平稳地进行光催化反应。
• THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT
  申请人：Kataoka Tohru

  公开号：US20140194412A1

  公开（公告）日：2014-07-10

  The present invention provides an anticancer drug having a Ras function inhibitory action. The present invention provides a Ras function inhibitor comprising a compound represented by the formula (I′): wherein each symbol is as defined in the present specification, or a salt thereof.

  本发明提供一种具有Ras功能抑制作用的抗癌药物。 本发明提供一种包括由式(I′)表示的化合物的Ras功能抑制剂： 其中每个符号如本说明书中所定义，或其盐。
• Ionic Liquid as Catalyst and Reaction Medium: A Simple and Efficient Procedure for Paal–Knorr Furan Synthesis
  作者：Gangqiang Wang、Zhi Guan、Rongchang Tang、Yanhong He

  DOI：10.1080/00397910902978049

  日期：2010.1.14

  The ionic liquid 1-butyl-3-methyl-imidazolium hydrogen sulfate, [bmim]HSO4, efficiently catalyzes Paal–Knorr furan synthesis without any organic solvent. A wide range of aliphatic and aromatic 1,4-diketones easily undergo condensations to form furan derivatives, providing a general and convenient procedure. The Paal–Knorr reaction of ester-substituted 1,4-diketones is first reported. The ionic liquid

  离子液体 1-丁基-3-甲基-咪唑硫酸氢盐 [bmim]HSO4 无需任何有机溶剂即可有效催化 Paal-Knorr 呋喃合成。广泛的脂肪族和芳香族 1,4-二酮很容易缩合形成呋喃衍生物，提供了一个通用和方便的程序。首次报道了酯取代的 1,4-二酮的 Paal-Knorr 反应。离子液体可以回收并重新用于后续运行，而不会显着降低效率。
• Palladium-catalyzed cross-coupling reactions of organomercurials with organic halides
  作者：N.A. Bumagin、P.G. More、I.P. Beletskaya

  DOI：10.1016/0022-328x(89)85346-x

  日期：1989.3

  Organomercurials, (A)2Hg (A = 5-methyl-2-furyl, thienyl) react with organic halides, ArI, in the presence of a palladium catalyst and iodide ion under argon to give cross-coupled products AAr, in high yields

  有机钯，（A）2 Hg（A = 5-甲基-2-呋喃基，噻吩基）在钯催化剂和碘离子的作用下，在氩气下与有机卤化物ArI反应，得到高交联产物A Ar产量