ethyl 3,3-bis(5-methylfur-2-yl)-3-phenylpropionate | 1159420-79-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 3,3-bis(5-methylfur-2-yl)-3-phenylpropionate
• 英文别名: Ethyl 3,3-bis(5-methylfuran-2-yl)-3-phenylpropanoate；ethyl 3,3-bis(5-methylfuran-2-yl)-3-phenylpropanoate
• CAS: 1159420-79-7
• 化学式: C₂₁H₂₂O₄
• 分子量: 338.403
• InChiKey: GELMZJJJXNONJG-UHFFFAOYSA-N

物化性质

• 沸点：
  446.5±40.0 °C(predicted)
• 密度：
  1.126±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲基呋喃 、 苯丙炔酸乙酯 在 potassium tetrachloroplatinate 、 silver trifluoromethanesulfonate 作用下， 以 溶剂黄146 为溶剂， 反应 12.0h， 以90%的产率得到ethyl 3,3-bis(5-methylfur-2-yl)-3-phenylpropionate
  参考文献：
  名称：

  Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans

  摘要：

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.022

文献信息

• CH bond functionalization of aromatic heterocycles with chelating dicarbene palladium(II) and platinum(II) complexes
  作者：Gabriella Buscemi、Andrea Biffis、Cristina Tubaro、Marino Basato、Claudia Graiff、Antonio Tiripicchio

  DOI：10.1002/aoc.1595

  日期：——

  Chelating dicarbene complexes of palladium(II) and platinum(II) catalyse at room temperature with 1% catalyst loading the reaction of ethyl phenylpropiolate with aromatic heterocycles to yield synthetically useful intermediates for fine chemicals without the need to use prefunctionalized substrates. The reaction outcome was found to be strongly dependent on the nature of the anionic ligands at the

  钯（II）和铂（II）的螯合二卡宾络合物在室温下以1％的催化剂催化，负载丙丙酸乙酯与芳族杂环的反应，从而制得用于精细化学品的合成有用的中间体，而无需使用预功能化的底物。发现反应结果在很大程度上取决于金属络合物上阴离子配体的性质。添加银盐以更弱的配位阴离子取代卤化物配体可提高反应收率并改变产物分布：杂环与常规的氢芳基化产物一起获得炔2：1的加合物，这潜在地扩大了反应的范围。还发现所用杂环的性质，特别是其空间特性，强烈影响反应的结果。版权所有©2009 John Wiley＆Sons，Ltd.
• Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans
  作者：Juzo Oyamada、Tsugio Kitamura

  DOI：10.1016/j.tet.2009.03.022

  日期：2009.5

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.