2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (Z)-octadec-9-enoate | 9005-65-6

• 物质功能分类: 表面活性剂 - 非离子表面活性剂 - 多元醇酯型
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (Z)-octadec-9-enoate
• CAS: 9005-65-6；9050-57-1
• 化学式: C₃₂H₆₀O₁₀
• 分子量: 604.8
• InChiKey: HDTIFOGXOGLRCB-KTKRTIGZSA-N

物化性质

• 熔点：
  -25 °C
• 沸点：
  >100°C
• 密度：
  1.08 g/mL at 20 °C
• 闪点：
  >230 °F
• 溶解度：
  可溶于DMSO（水中的溶解度为）、甲醇（微量）
• LogP：
  4.392 (est)
• 物理描述：
  Polysorbate 80 is an amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste. (NTP, 1992)
• 颜色/状态：
  Yellow to orange colored, oily liquid
• 稳定性/保质期：
  Polysorbates are stable to electrolyes and weak acids and bases; gradual saponification occurs with strong acids and bases. The oleic acid esters are sensitive to oxidation. Polysorbates are hygroscopic and should be examined for water content prior to use and dried if necessary. Also, in common with other polyoxyethylene surfactants, prolonged storage can lead to the formation of peroxides.
• 分解：
  When heated to decomposition it emits acrid smoke and irritating fumes.
• 粘度：
  300-500 cSt at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  42
• 可旋转键数：
  31
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  10

ADMET

毒理性

• 相互作用

聚山梨酯80对甲氨蝶呤（MTX）的生物利用度和分布的影响在口服给药后在NMRI和Porton小鼠中进行了研究。在这两种品系的小鼠中，这种非离子表面活性剂增加了MTX在各种器官中的浓度。

Effect of polysorbate 80 on the bioavailability and distribution of methotrexate (MTX) was studied in NMRI and Porton mice following oral administration. In these two strains of mice concentrations of MTX were increased in various organs by this nonionic surfactant.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

Tween 80增强了道诺霉素对Ehrlich腹水瘤大鼠和离体肿瘤细胞的抗肿瘤效果。在亚细胞水平上，Tween 80增加了道诺霉素与细胞核和线粒体的结合。

Tween 80 potentiated the antitumor effects of daunomycin both in rats with Ehrlich ascites tumor and in isolated tumor cells. At the subcellular level, Tween 80 increased binding of daunomycin to the nucleus and mitochondria.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

在中国仓鼠细胞系对放线菌素D和道诺霉素具有抗性的培养中，使用非离子表面活性剂Tween 80的处理增强了这两种抗生素在生长研究中的效果，并促进了摄取。

In cultures of Chinese hamster cell lines resistant to actinomycin D and daunomycin, treatment with the nonionic surfactant Tween 80 potentiated the effects of the 2 antibiotics in growth studies and enhanced uptake.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

多柔比星在10%吐温80水溶液中，通过静脉注射给携带肉瘤的小鼠，比单独给予多柔比星具有更高的抗肿瘤活性，并且在小鼠的脾脏、肺和肾脏中产生更高的多柔比星水平。

Adriamycin in a 10% Tween 80 aqueous solution injected iv into sarcoma-bearing mice had higher antitumor activity and produced higher adriamycin levels in the spleen, lung, and kidney than did adriamycin given alone.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者身体前倾或将其置于左侧（如果可能，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xi
• 安全说明：
  S24/25
• 危险类别码：
  R36/37/38,R22,R37/38,R41
• WGK Germany：
  1
• 海关编码：
  2932999099,34021300
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  WG2934000

制备方法与用途

吐温80是一种常用的表面活性剂,具有优良的乳化、分散等性能。它在多个领域都有广泛的应用,包括:

1. 食品工业:作为冰淇淋、面包糕点、糖果等的乳化剂和增稠剂,改善食品品质。

2. 化妆品行业:用作润湿剂、扩散剂、稳定剂等。

3. 纺织印染:作为柔软剂、抗静电剂等。

4. 油漆工业:用于涂料生产中作分散剂。

5. 药物制剂:作为药物载体,提高药效。

6. 农业领域:用作农药乳化剂,增加药效。

7. 金属加工:用于防锈清洗液。

8. 生物化学:作为O/W型乳化剂,用于制备生物样品等。

9. 气相色谱固定液。

10. 增溶剂。

其主要特点包括优良的乳化、分散性能;对皮肤刺激性小;可生物降解等优点,因此应用非常广泛。但在使用时需要注意控制用量,以免产生不良影响。

您提供的信息涵盖了吐温80的主要用途、生产方法以及在不同领域的应用实例,这些内容对于了解其性质和用法很有帮助。如果您有具体的应用需求或问题,可以进一步详细说明,我会尽力提供更针对性的帮助。

文献信息

• Oral Moisturizer for Alleviating Dry Mouth
  申请人：Hanifl Paul H.

  公开号：US20100022471A1

  公开（公告）日：2010-01-28

  An oral moisturizer is disclosed to provide relief from dry mouth. The moisturizer may be provided in different flavors that are palatable, with clinical benefits such as anti-nausea, appetite stimulant, etc., in addition to relief from the deteriorating dental effects of dry mouth. One disclosed oral moisturizer includes glycerin, xylitol, sodium hyaluronate, cetylpyridinium chloride, polysorbate surfactants and a palatable flavor.

  一种口腔保湿剂被披露用于缓解口干。该保湿剂可以提供不同口味，具有可口的临床益处，例如抗恶心、食欲刺激等，除了缓解口干引起的牙齿恶化效应。其中一种披露的口腔保湿剂包括甘油、木糖醇、透明质酸钠、十六烷基吡啶氯化物、聚山梨醇表面活性剂和可口的香味。
• Compositions containing non-polar compounds
  申请人：Bromley Philip J.

  公开号：US20090317532A1

  公开（公告）日：2009-12-24

  Provided herein are compositions and methods for preparing foods and beverages that contain additives. Additives include nutraceuticals, pharmaceuticals, and supplements, such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including Coenzyme Q10, and other oil-based additives.
• Method for Measuring Lipoprotein-Specific Apolipoproteins
  申请人：Contois John

  公开号：US20100323376A1

  公开（公告）日：2010-12-23

  The present invention is directed to methods of measuring the concentration of lipoprotein particles and/or lipoprotein-specific apolipoproteins in a biological fluid using an immunoassay, without the need of preliminary physical separation of the various types of lipoprotein particles present in the biological fluid.
• METHODS OF INHIBITING, PREVENTING, KILLING AND/OR REPELLING INSECTS USING SIMULATED BLENDS OF CHENOPODIUM EXTRACTS
  申请人：JIMENEZ Desmond

  公开号：US20100316738A1

  公开（公告）日：2010-12-16

  The present invention provides natural and/or simulated, synthetic, synergistic pesticidal compositions comprising terpenes, such as extracts from Chenopodium ambrosioides near ambrosioides , or compositions based on those found in Chenopodium ambrosioides near ambrosioides . The present invention also provides methods of using said compositions to kill, inhibit, prevent and/or repel plant pests from contacting and/or damaging plants.
• Bioavailability Enhancement Delivery Composition
  申请人：Patel Bhiku G.

  公开号：US20120252906A1

  公开（公告）日：2012-10-04

  A composition for increasing the bioavailability of an active pharmaceutical ingredient (“API”) in humans and animals, comprising a first water soluble surfactant having a cloud point greater than about 37° C., a second water soluble surfactant having a cloud point greater than about 37° C., wherein a mixture of the first surfactant and the second surfactant comprises a cloud point less than about 37° C.