3-ethylamino-3-[2]furyl-2-nitro-propionic acid ethyl ester | 874005-46-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-ethylamino-3-[2]furyl-2-nitro-propionic acid ethyl ester
• 英文别名: 3-Aethylamino-3-[2]furyl-2-nitro-propionsaeure-aethylester；Ethyl 3-(ethylamino)-3-(furan-2-yl)-2-nitropropanoate；ethyl 3-(ethylamino)-3-(furan-2-yl)-2-nitropropanoate
• CAS: 874005-46-6
• 化学式: C₁₁H₁₆N₂O₅
• 分子量: 256.258
• InChiKey: CGFPLJZQRGQAKH-UHFFFAOYSA-N

物化性质

• 沸点：
  349.6±42.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  97.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-ethylamino-3-[2]furyl-2-nitro-propionic acid ethyl ester 在 乙醇 、 铂 作用下， 生成 乙基呋喃-2-基甲胺
  参考文献：
  名称：

  Dornow et al., Justus Liebigs Annalen der Chemie, 1954, vol. 588, p. 62,67

  摘要：

  DOI：
• 作为产物：
  描述：

  糠醛 、 硝基乙酸乙酯 在 乙胺 、 Petroleum ether 作用下， 生成 3-ethylamino-3-[2]furyl-2-nitro-propionic acid ethyl ester
  参考文献：
  名称：

  Retinal blood flow and systemic blood pressure in healthy young subjects

  摘要：

  Background: The aim of the present study was to investigate the association between systemic blood pressure and retinal blood flow in healthy young subjects. Methods: Three independent study cohorts were included. A cross-sectional study was performed in 420 young male subjects with systolic blood pressure less than or equal to 160 mmHg and diastolic blood pressure less than or equal to 100 mmHg. Retinal white blood cell flux (n=210) and blood velocity in the central retinal artery (n=210) were measured. In addition, a longitudinal study was performed in 40 young male subjects in whom retinal and systemic haemodynamic parameters were measured thrice within 6 weeks. Retinal white blood cell flux was measured with the blue-field entoptic technique. Blood flow velocity in the central retinal artery was measured by means of colour Doppler imaging. Results: Retinal white blood cell flux (r=0.262; P <0.001) and mean flow velocity in the central retinal artery (r=0.174, P=0.010) were significantly associated with mean arterial pressure in the cross-sectional study. In the longitudinal study retinal white blood cell flux and mean flow velocity in the central retinal artery were also correlated with systemic blood pressure. Conclusions: Our data indicate a slight but significant increase in retinal blood flow with blood pressure. Whether this is of clinical relevance in eye diseases with altered retinal perfusion, such as diabetic retinopathy, remains to be established.

  DOI：

  10.1007/s004170100333

文献信息

• Dornow et al., Justus Liebigs Annalen der Chemie, 1954, vol. 588, p. 62,67
  作者：Dornow et al.

  DOI：——

  日期：——
• Retinal blood flow and systemic blood pressure in healthy young subjects
  作者：Gabriele Fuchsjäger-Mayrl、Kaija Polak、Alexandra Luksch、Elzbieta Polska、Guido T. Dorner、Georg Rainer、Hans-Georg Eichler、Leopold Schmetterer

  DOI：10.1007/s004170100333

  日期：2001.9

  Background: The aim of the present study was to investigate the association between systemic blood pressure and retinal blood flow in healthy young subjects. Methods: Three independent study cohorts were included. A cross-sectional study was performed in 420 young male subjects with systolic blood pressure less than or equal to 160 mmHg and diastolic blood pressure less than or equal to 100 mmHg. Retinal white blood cell flux (n=210) and blood velocity in the central retinal artery (n=210) were measured. In addition, a longitudinal study was performed in 40 young male subjects in whom retinal and systemic haemodynamic parameters were measured thrice within 6 weeks. Retinal white blood cell flux was measured with the blue-field entoptic technique. Blood flow velocity in the central retinal artery was measured by means of colour Doppler imaging. Results: Retinal white blood cell flux (r=0.262; P <0.001) and mean flow velocity in the central retinal artery (r=0.174, P=0.010) were significantly associated with mean arterial pressure in the cross-sectional study. In the longitudinal study retinal white blood cell flux and mean flow velocity in the central retinal artery were also correlated with systemic blood pressure. Conclusions: Our data indicate a slight but significant increase in retinal blood flow with blood pressure. Whether this is of clinical relevance in eye diseases with altered retinal perfusion, such as diabetic retinopathy, remains to be established.