1,1,1-trifluoro-4-phenylbut-3-ene | 17531-34-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,1-trifluoro-4-phenylbut-3-ene
• 英文别名: 1-phenyl-3-trifluoromethyl prop-1-ene；1-4,4,4-trifluoro-1-phenyl-but-1-ene；(4,4,4-trifluorobut-1-en-1-yl)benzene；4,4,4-Trifluor-1-phenylpropen-(1)；1.1.1-Trifluor-4-phenyl-buten-(3)；(4,4,4-Trifluoro-but-1-enyl)-benzene；4,4,4-trifluorobut-1-enylbenzene
• CAS: 17531-34-9
• 化学式: C₁₀H₉F₃
• 分子量: 186.177
• InChiKey: FWZOOPLHGYIYCO-UHFFFAOYSA-N

物化性质

• 沸点：
  80-83 °C(Press: 24 Torr)
• 密度：
  1.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,3,4,4,4-六氟-1-苯基丁烷-1-酮 在 盐酸 、 mercury dichloride 、 锌 作用下， 以 乙醇 、 水 为溶剂， 生成 1,1,1-trifluoro-4-phenylbut-3-ene
  参考文献：
  名称：

  含氟芳香酮的合成与反应

  摘要：

  通过苯甲醛与六氟丙烯的自由基加成反应合成了苯基1,1,2,3,3,3-六氟丙基酮(I)和2,2,3-三氟-3-(三氟甲基)茚满酮(II)。这些酮用 NaBH4 还原，并与这些酮的碘化甲基镁进行格氏反应，分别得到相应的仲醇和叔醇。还进行了克莱门森还原、碱性水解以及与羟胺和重氮甲烷的反应。

  DOI：

  10.1246/bcsj.49.1642

文献信息

• Trifluoroethylation of Alkynes: Synthesis of Allylic-CF₃ Compounds by Visible-Light Photocatalysis
  作者：Geum-bee Roh、Naeem Iqbal、Eun Jin Cho

  DOI：10.1002/cjoc.201500919

  日期：2016.5

  Two types of allylic trifluoromethylated compounds were synthesized by reacting alkynes with CF3CH2I using visible‐light photocatalysis. Subtle differences in the catalytic system controlled the selectivity of iodotrifluoroethylation and hydrotrifluoroethylation. The iodotrifluoroethylated products were obtained in the presence of [Ru(bpy)3]Cl2 and TMEDA in CH3CN under visible‐light irradiation, whereas

  通过使用可见光光催化，炔烃与CF 3 CH 2 I反应，合成了两种类型的烯丙基三氟甲基化化合物。催化体系的细微差别控制了碘三氟乙基化和氢三氟乙基化的选择性。碘三氟乙基化产物是在可见光照射下在CH 3 CN中存在[Ru（bpy）3 ] Cl 2和TMEDA的条件下获得的，而氢三氟乙基化产物是使用fac- [Ir（ppy）3 ]和DBU的混合物合成的和K 2 CO 3在DMF中。碘三氟乙基化反应即使在克级也能很好地发挥作用，并且碘三氟乙基化产物的偶联反应证明了其合成效用，可提供复杂的含CF 3产物。
• Trifluoromethylation of aliphatic halides with trifluoromethyl copper
  作者：Yoshiro Kobayashi、Kenjiro Yamamoto、Itsumaro Kumadaki

  DOI：10.1016/s0040-4039(01)86506-0

  日期：1979.1

  A solution of trifluoromethyl copper complex in hexamethylphosphoric triamide was found to be useful for trifluoromethylation of aliphatic halides.

  发现三氟甲基铜络合物在六甲基磷酸三酰胺中的溶液可用于脂族卤化物的三氟甲基化。
• BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale
  作者：Chong Han、Lady Mae Alabanza、Sean M. Kelly、Douglas L. Orsi、Francis Gosselin、Ryan A. Altman

  DOI：10.1021/acs.oprd.9b00201

  日期：2019.8.16

  We report a safe and readily prepared reagent [1,1′-biphenyl]-4-yl 2-bromo-2,2-difluoroacetate (BBDFA) for Cu-catalyzed trifluoromethylation of allylic or benzylic alcohols. An operationally simple and column-chromatography-free process to prepare BBDFA was developed and demonstrated on >100 g scale. Detailed reaction calorimetry and thermal analysis of the deoxytrifluoromethylation were performed

  我们报告了一种安全易用的试剂[1,1'-联苯] -4-基2-溴-2,2-二氟乙酸酯（BBDFA），用于铜催化的烯丙基或苄基醇的三氟甲基化。开发了制备BBDFA的操作简单且无需柱色谱的方法，并已证明其> 100 g规模。使用肉桂醇作为模型底物进行了详细的反应量热和脱氧三氟甲基化的热分析，表明该反应可以在制备规模上安全地进行。
• Culture vessel
  申请人：Menicon Co., Ltd.

  公开号：EP0890636A1

  公开（公告）日：1999-01-13

  A culture vessel wherein at least a part of the vessel is made of a gas permeable plastic material. In accordance with the present invention, it is provided the culture vessel which can be constantly and sufficiently supplied with a gas such as oxygen necessary for metabolism of cells without an oxygenator, and the like, and which is not contamined with bacteria and is easily transported.

  一种培养容器，其中至少有一部分是由可渗透气体的塑料材料制成的。根据本发明，所提供的培养容器可持续、充分地供应细胞新陈代谢所需的氧气等气体，无需增氧机等设备，而且不会受到细菌污染，便于运输。
• PROCESS FOR PRODUCING CONTACT LENS WITH HYDROPHILIC SURFACE AND CONTACT LENS OBTAINED THEREBY
  申请人：MENICON CO., LTD.

  公开号：EP0892297A1

  公开（公告）日：1999-01-20

  A process for producing a contact lens having a hydrophilic surface comprising subjecting a contact lens material comprising a copolymer prepared by copolymerizing a monomer mixture containing a polymerizable monomer (A) which is at least one member selected from a sugar ketal-containing (meth)acrylate and a sugar glycerol ketal-containing (meth)acrylate, and a polymerizable monomer (B) which is copolymerizable with the polymerizable monomer (A) to acid treatment, wherein the polymerizable monomer (B) contains a hydrophobic monomer which is at least one member selected from a silicon-containing monomer, a fluorine-containing monomer and a silicon- and fluorine-containing monomer, and a contact lens which has high oxygen permeability and of which surface shows stably excellent hydrophilic property and which is excellent in deposit resistance at the same time.

  一种生产具有亲水性表面的隐形眼镜的工艺，包括将隐形眼镜材料进行酸处理，该隐形眼镜材料包含通过共聚单体混合物制备的共聚物，该单体混合物包含可聚合单体(A)和可聚合单体(B)，可聚合单体(A)是至少一种选自含糖酮基(甲基)丙烯酸酯和含糖甘油酮基(甲基)丙烯酸酯的成员，可聚合单体(B)可与可聚合单体(A)共聚、其中，可聚合单体（B）含有一种疏水性单体，该疏水性单体至少选自含硅、含氟和含硅、含氟单体中的一种。