4,7-dithiadecane | 22037-97-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4,7-dithiadecane
• 英文别名: 1-[2-(propylsulfanyl)ethylsulfanyl]propane；1-(2-(propylsulfanyl)ethyl)propane；1,2-bis-propylsulfanyl-ethane；1,2-Bis-propylmercapto-aethan；Dithioaethylenglykol-dipropylaether；1-(2-propylsulfanylethylsulfanyl)propane
• CAS: 22037-97-4
• 化学式: C₈H₁₈S₂
• mdl: MFCD00027128
• 分子量: 178.363
• InChiKey: NUFUGDJGRYGRTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,7-dithiadecane 在 盐酸 、 二甲基亚砜 作用下， 生成 racem. 1,2-bis-(propane-1-sulfinyl)-ethane
  参考文献：
  名称：

  Transfer of oxygen to organic sulfides with dimethyl sulfoxide catalyzed by hydrogen chloride. Preparation of disulfoxides

  摘要：

  DOI：

  10.1021/jo00909a037
• 作为产物：
  描述：

  1,2-二氯乙烷 、 二丙基二硫 在 sodium hydroxide 、 一水合肼 作用下， 反应 2.0h， 以70%的产率得到4,7-dithiadecane
  参考文献：
  名称：

  摘要：

  A convenient preparative synthesis of bis(organylthio)alkanes was developed. It is based on alkylation with dihaloalkanes of solutions of diorganyl disulfides in the basic reductive system hydrazine hydrate-alkali. The generation of organylthiolate anions from disulfides and the subsequent reaction of the anions with dihaloalkanes are performed in one reaction vessel without isolation of intermediate alkali metal thiolates. At the same time, the reactions of diphenyl or dithienyl disulfides with dihaloalkanes result in substitution with the thiolate anions of only one halogen atom to give the corresponding unsymmetrical sulfides. In certain cases in the presence of excess alkali the latter sulfides are dehalogenated to form alkyl vinyl sulfides.

  DOI：

  10.1023/a:1015397313038

文献信息

• Preparation and characterization of [(LL)Cl2Mo]2(μ-SPr)2 compounds with Prn-propyl and LLPrSCH2CH2SPr and Et2PCH2CH2PEt2. Further examples of CS bond cleavage and oxidative addition across an MoMo quadruple bond
  作者：Joseph L. Deavenport、R.Theron Stubbs、Gregory L. Powell、Eric L. Sappenfield、Donard F. Mullica

  DOI：10.1016/0020-1693(93)03686-5

  日期：1994.1

  characteristic of MoMo double bonds. Bond lengths and angles are internally consistent and the van der Waals interactions are normal. Utilizing cone angle calculations, a ‘ligand profile’ describes the steric bulk about the phosphorus atoms in 2 looking down the MoP bonds. The resulting maximum half cone angles, θ/2, are 62±1.0°. Compound 1 was prepared by a reaction involving carbon-sulfur bond cleavage

  摘要合成了两个具有边缘共享生物锥面几何形状的二钼（III）配合物，并通过三维单晶X射线衍射法对其结构进行了表征。[（PrSCH 2 CH 2 SPr）Cl 2 Mo] 2（μ-SPr）2·0.5CH 2 Cl 2和[（Et 2 PCH 2 CH 2 PEt 2）Cl 2 Mo] 2（μ-SPr）2均Pr是正丙基，Et是乙基（以下分别称为1和2）在单斜晶系统中结晶，每个单元具有两个分子式单位（分别为C2 / m和P 2 1 / c）。MoMo双键的特征是2.的2.682（6）A的MoMo键距和2.的2.769（1）A的MoMo键距。键的长度和角度在内部是一致的，范德华相互作用是正常的。利用锥角计算，“配体分布”描述了从MoP键向下看的2中磷原子周围的空间体积。产生的最大半锥角θ/ 2为62±1.0°。通过涉及碳-硫键断裂的反应制备化合物1，并且分别通过涉及在Mo 2 Cl 4（PrSCH
• A straightforward and generalizable synthetic methodology for the synthesis of ruthenium(ii) complexes with thioether ligands from either Ru(iii) or Ru(0) precursors
  作者：Biplab K. Maiti、Helmar Görls、Olaf Klobes、Wolfgang Imhof

  DOI：10.1039/c0dt00051e

  日期：——

  The reaction of Ru3(CO)12 in chloroform with thioether ligands after 25 min of irradiation leads to the formation of mononuclear ruthenium(II) complexes of the general formula fac-[Ru(CO)3Cl2(S)] (S = thioether) if monodentate ligands are introduced. In the case of chelating bidentate thioethers a complex of the formula all-cis-[Ru(CO)2Cl2(S∩S)] is produced. If irradiation time is prolonged to 2.5

  的反应 Ru 3（CO）12 在 氯仿 辐照25分钟后与硫醚配体一起形成单核 钌（II） 通式的配合物 fac- [Ru（CO）3 Cl 2（S）]（S =硫醚）如果引入单齿配体。在螯合二齿硫醚的情况下，分子式为清一色顺- [钌（CO）2氯2（S∩S）]被生产。如果照射时间延长至2.5小时，则该组合物为单核络合物反式-[RuCl 2（S）4 ] 或者 反式-[RuCl 2（S∩S）2 ]被观察到。指某东西的用途四氢噻吩 （THT）在后一种情况下会产生双核 钌（II） 公式的复数[Ru 2（CO）2 Cl 4（THT）2（μ-THT）2]，这是第一个结构特征为中性的 钌桥联的硫醚配体的配合物。无论使用哪种配体配合物反式-[RuCl 2（S）4 ] 或者 反式-[RuCl 2（S∩S）2 ]由RuCl 3 ·3H 2 O与相应的硫醚在乙腈存在下的反应形成。NEt 3 和 甲醛高产。六个新钌 配合物的特征在于X射线衍射。
• Photochemical Synthesis of Ruthenium–Carbonyl Compounds with Thioether Ligands and Subsequent Oxidative Cleavage of Trinuclear Complexes by Chlorinated Solvents
  作者：Biplab K. Maiti、Helmar Görls、Olaf Klobes、Wolfgang Imhof

  DOI：10.1002/ejic.201000862

  日期：2011.4

  The photochemical reaction of [Ru3(CO)12] with thioether ligands in THF leads to the isolation of tetranuclear ruthenium–carbonyl cluster compounds of the formula [Ru4(CO)13(μ2-R2S)]. In these compounds, ruthenium atoms adopt a typical butterfly arrangement. If chelating ligands with two thioether functions are introduced, the reaction leads to mixtures of the trinuclear substitution products [Ru3(CO)10(RS∩SR)]

  [Ru3(CO)12]与THF中硫醚配体的光化学反应导致分离出式[Ru4(CO)13(μ2-R2S)]的四核钌-羰基簇化合物。在这些化合物中，钌原子采用典型的蝶形排列。如果引入具有两个硫醚官能团的螯合配体，则反应会产生三核取代产物 [Ru3(CO)10(RS∩SR)] 和 [Ru3(CO)8(RS∩SR)2] 的混合物。后者可以通过使用氯化溶剂氧化裂解以产生单核化合物 [Ru(CO)2Cl2(RS∩SR)] 或双核配合物 [Ru2(CO)2(μ2-Cl)2Cl2(RS∩SR) 2] 取决于反应条件。五种新的钌-羰基-硫醚配合物通过 X 射线衍射表征。
• The chemistry of molybdenum and tungsten. Part XIII. Molybdenum(V) complexes of dithiocarbamates and dithioethers
  作者：C.A. McAuliffe、B.J. Sayle

  DOI：10.1016/s0020-1693(00)89012-x

  日期：1978.1

  salts; infrared spectra indicate bidentate coordination by the ligands, and these complexes appear to have dodecahedral geometry. From this same reaction can be isolated the dimeric [Mo 2 O 4 (R 2 dtc) 2 ] species which contain a double MoOMo bridges as well as terminal MoO bonds, and also the [Mo 2 O 3 (Et 2 dtc)] complex containing a single MoOMo bridge and two terminal MoO linkages. With a series

  摘要三氯氧钼（V）与二硫代氨基甲酸酯反应。室温下乙腈中的R 2 dtc-（R 2Me 2，Et 2，[CH 2] 4）在末端钼-氧键裂解产生[Mo（R 2 dtc）4] +时分离为氯化物或四苯基硼酸盐；红外光谱表明配体的双齿配位，并且这些配合物似乎具有十二面体的几何形状。从同一反应中可以分离出二聚[Mo 2 O 4（R 2 dtc）2]物种，该物种包含一个双MoOMo桥以及末端MoO键，以及[Mo 2 O 3（ Et 2 dtc）]复合物，包含一个MoOMo桥和两个末端MoO链。使用一系列二硫醚生成三氧化氯钼（V）可以生成[MoO（配​​体）Cl 3]，但是络合的能力关键取决于二硫醚的结构。
• AMINOALCOHOL LIPIDOIDS AND USES THEREOF
  申请人：Mahon Kerry Peter

  公开号：US20110293703A1

  公开（公告）日：2011-12-01

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文描述了通过将胺与环氧末端化合物反应制备氨基醇脂质体的方法。还提供了从商业起始材料制备氨基醇脂质体的方法。氨基醇脂质体可以从外消旋或立体化学纯的环氧化合物制备。氨基醇脂质体或其盐形式最好是可生物降解和生物相容的，并可用于各种药物输送系统。鉴于这些氨基醇脂质体化合物的氨基基团，它们特别适用于多核苷酸的输送。已经制备了包含创新脂质体和多核苷酸的复合物、胶束、脂质体或粒子。创新脂质体也可以用于制备药物输送的微粒。鉴于它们能够缓冲其周围环境的pH值，它们在输送不稳定剂方面特别有用。