4-(dihexadecylmethyl)pyridine | 158014-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(dihexadecylmethyl)pyridine
• 英文别名: 4-(17-tritriacontyl)pyridine；4-(1-hexadecyl-heptadecyl)-pyridine；4-(1-Hexadecyl-heptadecyl)-pyridin；4-(1-hexadecylheptadecyl)pyridine；4-tritriacontan-17-ylpyridine
• CAS: 158014-84-7
• 化学式: C₃₈H₇₁N
• 分子量: 541.988
• InChiKey: YGBMMTBBECVGJN-UHFFFAOYSA-N

物化性质

• 沸点：
  612.6±24.0 °C(Predicted)
• 密度：
  0.863±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  18.2
• 重原子数：
  39
• 可旋转键数：
  31
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(dihexadecylmethyl)pyridine 在 Dowex (Cl^- form) 、 氢溴酸 作用下， 以 溶剂黄146 、 丙酮 为溶剂， 反应 504.0h， 生成 1-(4-ammoniobutyl)-4-(dihexadecylmethyl)pyridinium dichloride
  参考文献：
  名称：

  Synthesis of Pyridinium Amphiphiles Used for Transfection and Some Characteristics of Amphiphile/DNA Complex Formation

  摘要：

  DOI：

  10.1002/(sici)1099-0690(200002)2000:4<665::aid-ejoc665>3.0.co;2-a
• 作为产物：
  描述：

  4-甲基吡啶 、 alkaline earth salt of/the/ methylsulfuric acid 在 lithium diisopropyl amide 作用下， 以 乙醚 、 正己烷 为溶剂， 以90%的产率得到4-(dihexadecylmethyl)pyridine
  参考文献：
  名称：

  Synthesis of Pyridinium Amphiphiles Used for Transfection and Some Characteristics of Amphiphile/DNA Complex Formation

  摘要：

  DOI：

  10.1002/(sici)1099-0690(200002)2000:4<665::aid-ejoc665>3.0.co;2-a

文献信息

• PHARMACEUTICAL USE OF TERPYRIDINE DERIVATIVE
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0677293A1

  公开（公告）日：1995-10-18

  A terpyridine derivative represented by general formula (I) (wherein R represents hydrogen, (un)substituted phenyl, pyridyl, etc.), which has the effect of promoting the production of nerve growth factors or a neurotrophic factor activity. Hence it can be used as an ameliorant or remedy for the symptoms and diseases accompanying peripheral nerve degeneration which is idiopathic or caused by trauma, chemicals such as alcohol or anticancer drug, inflammation, or metabolism as observed in, for example, diabetes. In addition, it can be used as an ameliorant or remedy for the symptoms and diseases accompanying central nerve degeneration, such as senile dementia of Alzheimer type, cerebrovascular dementia, Down's syndrome, Parkinson's disease or Hantington's chorea, mental and motor function incompetences caused by cerebral ischemia, cerebral infarction, cerebral hemorrhage or head injury, spinal neuroparalysis, and so forth.

  一种由通式(I)代表的terpyridine衍生物（其中R代表氢、（未）取代的苯基、吡啶基等），具有促进神经生长因子或神经营养因子活性产生的作用。因此，它可作为一种改善剂或治疗剂，用于治疗特发性或由创伤、化学物质（如酒精或抗癌药物）、炎症或代谢（如糖尿病）引起的伴随周围神经变性的症状和疾病。此外，它还可用于改善或治疗中枢神经退化引起的症状和疾病，如阿尔茨海默型老年痴呆、脑血管性痴呆、唐氏综合征、帕金森病或汉廷顿舞蹈症、脑缺血、脑梗塞、脑出血或头部损伤引起的精神和运动功能障碍、脊髓神经麻痹等。
• Tchitchibabine, Bulletin de la Societe Chimique de France, 1938, vol. <5> 5, p. 429,432
  作者：Tchitchibabine

  DOI：——

  日期：——
• Thermotropic liquid-crystalline behavior of some single- and double-chained pyridinium amphiphiles
  作者：Ernst J. R. Sudholter、Jan B. F. N. Engberts、Wim H. De Jeu

  DOI：10.1021/j100207a035

  日期：1982.5
• EP677293
  申请人：——

  公开号：——

  公开（公告）日：——
• Multistimuli-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[6]arene and SAINT Complexation for Controllable Drug Release
  作者：Yu Cao、Xiao-Yu Hu、Yan Li、Xiaochun Zou、Shuhan Xiong、Chen Lin、Ying-Zhong Shen、Leyong Wang

  DOI：10.1021/ja505344t

  日期：2014.7.30

  Supramolecular binary vesicles based on the host-guest complexation of water-soluble pillar[6]arene (WP6) and SAINT molecule have been successfully constructed, which showed pH-, Ca2+, and thermal-responsiveness. These supramolecular vesicles can efficiently encapsulate model substrate calcein, which then can be efficiently released either by adjusting the solution pH to acidic condition due to the complete disruption of vesicular structure, or particularly, by adding a certain amount of Ca2+ due to the Ca2+-induced vesicle fusion and accompanied by the structure disruption. More importantly, drug loading and releasing experiments demonstrate that an anticancer drug, DOX, can be successfully encapsulated by the supramolecular vesicles, and the resulting DOX-loaded vesicles exhibit efficient release of the encapsulated DOX with the pH adjustment or the introduction of Ca2+. Cytotoxicity experiments suggest that the resulting DOX-loaded supramolecular vesides exhibit comparable therapeutic effect for cancer cells as free DOX and the remarkably reduced damage for normal cells as well. The present multistimuli-responsive supramolecular vesicles have great potential applications in the field of controlled drug delivery. In addition, giant supramolecular vesicles (similar to 3 mu m) with large internal volume and good stability can be achieved by increasing the temperature of WP6 superset of SAINT vesicular solution, and they might have potential applications for bioimaging.