1-(2,2-dimethoxy-ethyl)-pyrrolidin-2-one | 22676-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2,2-dimethoxy-ethyl)-pyrrolidin-2-one
• 英文别名: N-(2,2-Dimethoxy-ethyl)-pyrrolidon-(2)；1-(2,2-Dimethoxyethyl)pyrrolidin-2-one
• CAS: 22676-44-4
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: CMRGCFFHOJJGQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2,2-dimethoxy-ethyl)-pyrrolidin-2-one 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 1.0h， 生成 2-(1,3-benzodioxol-5-yl)-2-[1-(2,2-dimethoxyethyl)pyrrolidin-2-ylidene]acetonitrile
  参考文献：
  名称：

  Mattson, Ronald J.; Sowell, J. Walter; Bryson, Thomas A., Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 973 - 975

  摘要：

  DOI：
• 作为产物：
  描述：

  γ-丁内酯 、 氨基乙醛缩二甲醇 在 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 0.58h， 以54%的产率得到1-(2,2-dimethoxy-ethyl)-pyrrolidin-2-one
  参考文献：
  名称：

  Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids

  摘要：

  A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Bronsted acid. obtained in useful to excellent yields after only 35 min of microwave processing.

  DOI：

  10.1021/jo8015264

文献信息

• Efficient synthesis of N-substituted lactams from (N-arylsulfonyloxy) amines and cyclic ketones
  作者：Robert V. Hoffman、James M. Salvador

  DOI：10.1016/s0040-4039(01)80691-2

  日期：1989.1

  A new method is reported for the direct preparation of N-substituted lactams from cycloalkanones. N-(p-nitrobenzenesulfonoxyl) methylamine (CH3NH-OSO2C6H4NO2) was reacted with a series of cycloalkanones to give good yields of N-methyl lactams. An addition-rearrangement pathway accounts for the ring-expanded lactam products. A series of N-alkyl-N-arylsulfonoxyl amines were generated in situ and reacted

  报道了一种从环烷酮直接制备N-取代内酰胺的新方法。使N-（对硝基苯磺酰氧基）甲胺（CH 3 NH-OSO 2 C 6 H 4 NO 2）与一系列环烷酮反应，得到良好收率的N-甲基内酰胺。加成-重排途径解释了扩环的内酰胺产物。一系列原位生成N-烷基-N-芳基磺氧基胺，并与环丁酮反应以高收率得到N-烷基吡咯烷酮。
• [EN] FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS<br/>[FR] COMPOSÉS DE PYRIDONE POLYCYCLIQUES FUSIONNÉS UTILISÉS EN TANT QU'INHIBITEURS DE RÉPLICATION DU VIRUS DE LA GRIPPE
  申请人：NIKANG THERAPEUTICS INC

  公开号：WO2020205835A1

  公开（公告）日：2020-10-08

  Provided are compounds that inhibit orthomyxovirus replication such as Influenza viruses and are accordingly useful for treatment of viral infections caused by orthomyxoviruses. Also provided are pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent viral infections caused by orthomyxovirus such as Influenza viruses.

  提供了抑制正黏液病毒复制的化合物，如流感病毒，因此对治疗由正黏液病毒引起的病毒感染有用。还提供了含有这些化合物的药物组合物以及使用这些化合物治疗或预防由正黏液病毒引起的病毒感染的方法，如流感病毒。
• MATTSON, R. J.;SOWELL, J. W. ,, SR.;BRYSON, TH. A., J. HETEROCYCL. SHEM., 1985, 22, N 4, 973-975
  作者：MATTSON, R. J.、SOWELL, J. W. ,, SR.、BRYSON, TH. A.

  DOI：——

  日期：——
• Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids
  作者：Kristina M. Orrling、Xiongyu Wu、Francesco Russo、Mats Larhed

  DOI：10.1021/jo8015264

  日期：2008.11.7

  A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Bronsted acid. obtained in useful to excellent yields after only 35 min of microwave processing.
• Mattson, Ronald J.; Sowell, J. Walter; Bryson, Thomas A., Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 973 - 975
  作者：Mattson, Ronald J.、Sowell, J. Walter、Bryson, Thomas A.

  DOI：——

  日期：——