[bis-(4-nitro-phenoxy)-phosphoryl]-trichloroacetyl-amine | 38187-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [bis-(4-nitro-phenoxy)-phosphoryl]-trichloroacetyl-amine
• 英文别名: [Bis-(4-nitro-phenoxy)-phosphoryl]-trichloracetyl-amin；N-bis(4-nitrophenoxy)phosphoryl-2,2,2-trichloroacetamide
• CAS: 38187-67-6
• 化学式: C₁₄H₉Cl₃N₃O₈P
• 分子量: 484.574
• InChiKey: PCBUTVQVCCMWSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  156
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  Trichlorphosphazotrichloracetyl 、 4-(4-nitrophenoxy)butanoic acid 在 苯 作用下， 生成 [bis-(4-nitro-phenoxy)-phosphoryl]-trichloroacetyl-amine
  参考文献：
  名称：

  Kirsanow; Derkatsch, Zhurnal Obshchei Khimii, 1956, vol. 26, p. 2631,2637; engl. Ausg. S. 2935, 2940

  摘要：

  DOI：
• 作为试剂：
  描述：

  1,6-二仲丁基苯酚 、 六甲基二硅氮烷 在 [bis-(4-nitro-phenoxy)-phosphoryl]-trichloroacetyl-amine 作用下， 以 氯仿 为溶剂， 反应 3.5h， 以90%的产率得到[2,6-Di(butan-2-yl)phenoxy](trimethyl)silane
  参考文献：
  名称：

  Catalysts for silylations with 1,1,1,3,3,3-hexamethyldisilazane

  摘要：

  DOI：

  10.1021/jo00141a031

文献信息

• Process for the preparation of 7-acylamino-3-(thio-substituted)methyl-3-cephem-4-carboxylic acid 1-oxide derivatives
  申请人：GIST-BROCADES N.V.

  公开号：EP0047560A2

  公开（公告）日：1982-03-17

  Process for the preparation of 7-acylamino-3-(thio--substituted)methyl-3-cephem-4-carboxylic acid 1-oxide derivatives by reacting a 7-acylamino-3-bromomethyl-3--cephem-4-carboxylic acid 1-oxide derivative with a silylated thiol of the general formula: wherein R represents an organic group, preferably a 5- or 6-membered heterocyclic group, which reaction is preferably carried out in the presence of an inert organic solvent at a temperature between - 20° and 80°C thereby obtaining the corresponding 7-acylamino-3-(R--thiomethyl)-3-cephem-4-carboxylic acid 1-oxide derivatives, many of which are valuable intermediates in methods for the preparation of therapeutically active cephalosporins.

  7-acylamino-3-(thio--substituted)methyl-3-cephem-4-carboxylic acid 1-oxide derivatives 的制备方法，该方法是将 7-acylamino-3-bromomethyl-3-cephem-4-carboxylic acid 1-oxide derivatives 与通式如下的硅烷化硫醇反应： 其中 R 代表有机基团，最好是 5 或 6 元杂环基团，该反应最好在惰性有机溶剂存在下进行，温度在 -20° 至 80°C 之间，从而得到相应的 7-酰氨基-3-(R--硫甲基)-3-头孢-4-羧酸 1-氧化物衍生物，其中许多衍生物是制备具有治疗活性的头孢菌素的重要中间体。
• Improved process for the silylation of organic compounds with 1,1,1-trimethyl-N-(trimethylsilyl)silanamine by means of catalysis with certain nitrogen containing compounds
  申请人：GIST-BROCADES N.V.

  公开号：EP0043630A2

  公开（公告）日：1982-01-13

  Improved process for the silylation of organic compounds with 1,1,1-trimethyl-N-(trimethyl)silanamine by means of catalysis with certain nitrogen containing organic compounds. The organic compounds which may be silylated by the improved process are carrying one or more -OH, -NH or SH groups, for example alcohols, phenols, carboxylic acids, amines, amides, aminoacids and thiols. The nitrogen containing catalysts are compounds with the general formula wherein X represents a hydrogen atom, a trialkylsilyl group or an electron-withdrawing group and Y represents an electron-withdrawing group. Novel trimethylsilylated thiols and novel trimethylsilylated 3'-substituted cephalosporanic acid derivatives are prepared by the improved process.

  用 1,1,1-三甲基-N-(三甲基)硅烷胺与某些含氮有机化合物催化硅烷化的改进工艺。可通过改进工艺进行硅烷化的有机化合物带有一个或多个-OH、-NH 或 SH 基团，例如醇、酚、羧酸、胺、酰胺、氨基酸和硫醇。含氮催化剂是通式如下的化合物 其中 X 代表氢原子、三烷基硅烷基或抽电子基团，Y 代表抽电子基团。新型三甲基硅烷基化硫醇和新型三甲基硅烷基化 3'-取代头孢菌素酸衍生物是通过改进的工艺制备的。
• A process for preparing acid halides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0381451A1

  公开（公告）日：1990-08-08

  An improved process for preparing trialkylsilyl ester and acid halide derivatives of carboxylic acids is provided along with novel trialkylsilyl ester intermediates of 2-(2-furyl)-2-methoximinoacetic acid.

  本研究提供了一种制备羧酸三烷基硅酯和酸卤化物衍生物的改进工艺，以及 2-(2-呋喃基)-2-甲氧基亚氨基乙酸的新型三烷基硅酯中间体。
• US4379923A
  申请人：——

  公开号：US4379923A

  公开（公告）日：1983-04-12
• US4400509A
  申请人：——

  公开号：US4400509A

  公开（公告）日：1983-08-23