(2-(ethylsulfonyl)ethyl)benzene | 66499-26-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-(ethylsulfonyl)ethyl)benzene
• 英文别名: Ethyl-phenethylsulfon；Ethyl-β-phenethyl-sulfon；ethyl-phenethyl sulfone；Aethyl-phenaethyl-sulfon；2-Ethylsulfonylethylbenzene
• CAS: 66499-26-1
• 化学式: C₁₀H₁₄O₂S
• 分子量: 198.286
• InChiKey: FAGAMRXHFPIDJP-UHFFFAOYSA-N

物化性质

• 熔点：
  79-80 °C
• 沸点：
  369.9±21.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲醛 在 哌啶 、 吡啶 、 palladium on activated charcoal 、 溶剂黄146 作用下， 生成 (2-(ethylsulfonyl)ethyl)benzene
  参考文献：
  名称：

  SOME KNOEVENAGEL REACTIONS WITH ETHYLSULFONYLACETIC ACID

  摘要：

  DOI：

  10.1021/jo01365a006

文献信息

• General sulfone construction <i>via</i> sulfur dioxide surrogate control
  作者：Shihao Chen、Yaping Li、Ming Wang、Xuefeng Jiang

  DOI：10.1039/c9gc03841h

  日期：——

  sulfones with a facile combination of halides, sulfur dioxide surrogates and phosphate esters is described. When thiourea dioxide was employed as a reductive sulfur dioxide surrogate, alkyl–alkyl sulfones were obtained under transition metal free conditions. Aryl–alkyl sulfones were obtained with an extremely low catalytic loading (0.2 mol%) via altering the mask of sulfur dioxide surrogates to sodium

  描述了一种高效的一步法合成烷基-烷基和芳基-烷基砜以及卤化物，二氧化硫替代物和磷酸酯的简便组合物。当使用二氧化硫脲作为还原性二氧化硫替代物时，在无过渡金属的条件下获得了烷基-烷基砜。通过改变二氧化硫代用品对连二亚硫酸钠的掩膜，可以以极低的催化负载量（0.2摩尔％）获得芳基烷基砜。使用磷酸酯作为稳定且容易获得的烷基源。值得注意的是，该协议已应用于天然产物和生物活性分子的后期修饰。
• Parakeratosis inhibitor, pore-shrinking agent,or rough skin preventing/ameliorating agent, and external composition for skin
  申请人：Kaminuma Mikiko

  公开号：US20090215893A1

  公开（公告）日：2009-08-27

  The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin-inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and to further provide an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor agent, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof. The external composition for skin comprises the one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.

  本发明提供了一种角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂，具有角化不全抑制、毛孔收缩或防止/减轻粗糙皮肤等功能，不会引起感觉刺激等安全问题，非常安全，进一步提供了一种添加了具有上述功能的化合物的皮肤外用组合物。该角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂包含从α-氨基酸衍生物和其盐的组中选择的一种、两种或更多化合物。该皮肤外用组合物包含从α-氨基酸衍生物和其盐的组中选择的一种、两种或更多化合物，作为上述角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂。
• WRINKLE-IMPROVING AGENT
  申请人：Kaminuma Mikiko

  公开号：US20120165409A1

  公开（公告）日：2012-06-28

  A wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.

  一种改善皱纹的剂，具有改善皱纹的效果，即使涂抹在皮肤上也不会产生安全或疼痛问题，并且包含一种非常安全的物质作为活性成分。发现N-苯甲酰-β-丙氨酸、其他特定的β-丙氨酸衍生物及其盐具有改善皱纹的效果，因此开发了一种皱纹改善剂，其活性成分包含从这些特定的β-丙氨酸衍生物和其盐组成的群体中选择的一种、两种或更多种化合物。
• Kuchin,A.V. et al., Journal of general chemistry of the USSR, 1979, vol. 49, # 2, p. 351 - 356
  作者：Kuchin,A.V. et al.

  DOI：——

  日期：——
• SOME KNOEVENAGEL REACTIONS WITH ETHYLSULFONYLACETIC ACID
  作者：EDWARD A. FEHNEL、PAUL R. RESNICK

  DOI：10.1021/jo01365a006

  日期：1955.8