4-anilino-N-methyl-N-phenylpiperidine-4-carboxamide | 343608-23-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-anilino-N-methyl-N-phenylpiperidine-4-carboxamide
• CAS: 343608-23-1
• 化学式: C₁₉H₂₃N₃O
• 分子量: 309.411
• InChiKey: UYSCGKMXQUDPTP-UHFFFAOYSA-N

物化性质

• 沸点：
  483.6±45.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-anilino-N-methyl-N-phenylpiperidine-4-carboxamide 在 sodium hydroxide 、 水 、 异丙醇 作用下， 155.0 ℃ 、482.64 kPa 条件下， 反应 24.0h， 生成 N-phenyl-α-(4-piperidino)glycine
  参考文献：
  名称：

  WO2007/87164

  摘要：

  公开号：

文献信息

• Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation
  申请人：KERN PHARMA, S.L.

  公开号：EP1867635A1

  公开（公告）日：2007-12-19

  A process for preparing remifentanil by conversion of the nitrile group of a cyanopiperidinyl propanoate derivative to an ester group. Advantageously, with this process the number of steps for preparing remifentanil from commercial products is significantly reduced, compared to the processes known in the art.

  通过将氰基哌啶丙酸酯衍生物的腈基转化为酯基来制备雷米芬太尼的方法。优点是，与已知的工艺相比，使用这种方法从商业产品制备雷米芬太尼的步骤数量大大减少。
• PROCESS FOR PREPARING REMIFENTANIL, INTERMEDIATES THEREOF, USE OF SAID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION
  申请人：Kern Pharma, S.L.

  公开号：EP2044021B1

  公开（公告）日：2010-03-31
• Process for Synthesizing Remifentanil
  申请人：Cheng Brian K.

  公开号：US20080312448A1

  公开（公告）日：2008-12-18

  A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of synthetic opiate or opioid compounds. The process comprising reacting a 4-amino 4-carbamyl piperidine with a base in a closed reaction chamber at elevated temperature and pressure to form to intermediate which may be esterified with an alcohol, alkylated, and acylated to produce a synthetic opiate or opioid compound.
• PROCESS FOR PREPARING REMIFENTANIL, INTERMEDIATES THEREOF, USE OF SAID INTERMEDIATES AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：Cervelló Pagès Jorge

  公开号：US20100016601A1

  公开（公告）日：2010-01-21

  A process for preparing remifentanil by conversion of the nitrile group of a cyanopiperidinyl propanoate derivative to an ester group. Advantageously, with this process the number of steps for preparing remifentanil from commercial products is significantly reduced, compared to the processes known in the art.
• US7208604B2
  申请人：——

  公开号：US7208604B2

  公开（公告）日：2007-04-24