2-(4-phenylphenyl)-1,3-dioxane | 135655-74-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-phenylphenyl)-1,3-dioxane
• 英文别名: 1,3-Dioxane, 2-[1,1'-biphenyl]-4-yl-
• CAS: 135655-74-2
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: LZCICJCYLSXUHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-phenylphenyl)-1,3-dioxane 在 水 、 溶剂黄146 作用下， 反应 1.5h， 生成 对苯基苯甲醛
  参考文献：
  名称：

  Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization

  摘要：

  The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chemical motif that was subsequently optimized to arrive at a chemical series of potent and promising SCD1 inhibitors. In particular, compound SAR224 was selected for further pharmacological profiling based on favorable in vitro data. After oral administration to male ZDF rats, this compound significantly decreased the serum fatty acid desaturation index, thus providing conclusive evidence for SCD1 inhibition in vivo by SAR224. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.030
• 作为产物：
  描述：

  对苯基苯甲醛 、 1,3-丙二醇 在 mesoporous poly-melamine-formaldehyde polymer 作用下， 以 neat (no solvent) 为溶剂， 反应 24.0h， 以90%的产率得到2-(4-phenylphenyl)-1,3-dioxane
  参考文献：
  名称：

  介孔聚三聚氰胺-甲醛（mPMF）–醛化学选择性缩醛化的高效催化剂

  摘要：

  研究了具有高表面积，良好的孔隙率以及高密度的胺和三嗪官能团的介孔聚三聚氰胺-甲醛聚合物作为高效的氢键催化剂。发现该多孔有机聚合物在催化醛的化学选择性缩醛化方面非常有效，而无需消耗任何脱水剂。中孔聚三聚氰胺-甲醛的周转频率比三聚氰胺单体高数百倍，而这种高效率是由于氨醛（–NH–CH 2-NH-）基团和聚合物网络中的三嗪环，这提供了具有多个氢键的内在强大的系统。这种独特的特性使中孔聚三聚氰胺-甲醛聚合物作为非均相有机催化剂具有很高的活性。该聚合物也是低成本的，并且易于合成和再循环。

  DOI：

  10.1039/c3gc40297e

文献信息

• [EN] A METHOD OF ACETALIZING AN ALDEHYDE<br/>[FR] PROCÉDÉ D'ACÉTALISATION D'UN ALDÉHYDE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2013137830A1

  公开（公告）日：2013-09-19

  A method of acetalizing an aldehyde comprising reacting said aldehyde with an alcohol in the presence of a polymeric catalyst to form an acetal wherein the polymeric catalyst is a mesoporous poly-melamine-formaldehyde polymer.

  一种使醛发生缩醛化的方法，包括将所述醛与醇在多孔聚三聚氰胺-甲醛聚合物的催化下反应，形成缩醛。
• METHOD FOR PRODUCING CARBONATE DERIVATIVE
  申请人：NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

  公开号：US20210403409A1

  公开（公告）日：2021-12-30

  The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently even without using a base. The method for producing a carbonate derivative according to the present invention is characterized in comprising the step of irradiating a high energy light to a composition comprising the halogenated methane and the hydroxy group-containing compound in the presence of oxygen, wherein a molar ratio of a total usage amount of the hydroxy group-containing compound to 1 mole of the halogenated methane is 0.05 or more.

  本发明的目标是提供一种即使不使用碱也能安全高效生产聚碳酸酯的方法。根据本发明的碳酸酯衍生物生产方法的特征在于，在氧气存在的情况下，将含卤代甲烷和含羟基化合物的组合物照射高能光，其中羟基化合物总使用量与1摩尔卤代甲烷的摩尔比为0.05或更高。
• Superacid-Catalyzed Reductive Friedel−Crafts Reaction of Arenes Using Arenecarbaldehyde Acetals
  作者：Shin-ichi Fukuzawa、Teruhisa Tsuchimoto、Tamejiro Hiyama

  DOI：10.1021/jo961897e

  日期：1997.1.1

  Reaction of 2-aryl-1,3-dioxane with arenes in the presence of a catalytic amount of trifluoromethanesulfonic acid gave the corresponding diarylmethanes in good to excellent yields. The acid-catalyzed Friedel-Crafts benzylation of arenes could altenatively be carried out using arenecarbaldehyde and 1,3-propanediol. The reaction was assumed to proceed through a redox process involving hydride shift from the cyclic acetal moiety to the benzylic carbon. The hydride shift was confirmed by the reaction with 5-ethyl-2-phenyl-4,4,6,6-tetradeuterio-1,3-dioxane, wherein more than 90% deuterium was incorporated into the benzylic carbon of the diphenylmethane. Diphenylmethyl ether Ph(2)CHOCH(2)CH(2)CH(2)OH also reacted with benzene to afford diphenylmethane under the same reaction conditions, suggesting that the ether should be the plausible intermediate that underwent the hydride shift.
• METHOD FOR PRODUCING POLYCARBONATE
  申请人：NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

  公开号：US20210388159A1

  公开（公告）日：2021-12-16

  The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently. A method for producing a polycarbonate is characterized in comprising the step of irradiating a light to a composition comprising a C 1-4 halogenated hydrocarbon, the specific diol compound and the specific base in the presence of oxygen.
• Mesoporous poly-melamine-formaldehyde (mPMF) – a highly efficient catalyst for chemoselective acetalization of aldehydes
  作者：Mei Xuan Tan、Liuqun Gu、Nannan Li、Jackie Y. Ying、Yugen Zhang

  DOI：10.1039/c3gc40297e

  日期：——

  A mesoporous poly-melamine-formaldehyde polymer with a high surface area, good porosity and a high density of amine and triazine functional groups was investigated as a highly efficient hydrogen-bonding catalyst. This porous organic polymer was found to be highly effective in catalyzing chemoselective acetalization of aldehydes, without the consumption of any dehydrating agents. The turnover frequency

  研究了具有高表面积，良好的孔隙率以及高密度的胺和三嗪官能团的介孔聚三聚氰胺-甲醛聚合物作为高效的氢键催化剂。发现该多孔有机聚合物在催化醛的化学选择性缩醛化方面非常有效，而无需消耗任何脱水剂。中孔聚三聚氰胺-甲醛的周转频率比三聚氰胺单体高数百倍，而这种高效率是由于氨醛（–NH–CH 2-NH-）基团和聚合物网络中的三嗪环，这提供了具有多个氢键的内在强大的系统。这种独特的特性使中孔聚三聚氰胺-甲醛聚合物作为非均相有机催化剂具有很高的活性。该聚合物也是低成本的，并且易于合成和再循环。