2-hydroxyethyl-4-formylbenzoate | 28129-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxyethyl-4-formylbenzoate
• 英文别名: 2-Hydroxyethyl 4-formylbenzoate
• CAS: 28129-14-8
• 化学式: C₁₀H₁₀O₄
• mdl: MFCD24390043
• 分子量: 194.187
• InChiKey: YCICRKPCHZPVHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  374.6±27.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydroxyethyl-4-formylbenzoate 在 咪唑 、 potassium iodide 、 potassium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 3.0h， 生成 2-((tert-butyldimethylsilyl)oxy)ethyl 4-(3-benzoyloxiran-2-yl)benzoate
  参考文献：
  名称：

  无过氧化物和过渡金属的电化学合成α，β-环氧酮

  摘要：

  报道了一种新的合成α，β-环氧酮的电化学方法。用KI作为氧化还原介体，甲基酮在无过氧化物和过渡金属的电解条件下与醛反应，并在一锅中得到α，β-环氧酮（36例，产率52-90％）。这种安全且环保的方法具有广泛的底物范围，并且可以轻松提供以克为单位的多种α，β-环氧酮，以评估其抗癌活性。

  DOI：

  10.1039/d0ob02444a
• 作为产物：
  描述：

  对醛基苯甲酸 、 2-溴乙醇 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-hydroxyethyl-4-formylbenzoate
  参考文献：
  名称：

  同时控制复杂介质中单链聚合物纳米粒子的构象和操作稳定性

  摘要：

  包含溶剂化变色吡唑啉加合物的单链聚合物纳米粒子 (SCPNs) 在复杂介质和细胞区室中表现出构象和操作稳定性；加合物的连通性对于调节与周围介质的相互作用至关重要。

  DOI：

  10.1039/d3cc00763d

文献信息

• Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208
  作者：Ping Yu、Wenjing Liu、Jinghui Ren、Yingying Wang、Yao Ning、Mingqi Huang、Xinyi Hu、Lili Wei、Min Ji、Jin Cai

  DOI：10.1016/j.bmcl.2019.06.028

  日期：2019.8

  disorders. In this study, we introduced the pharmacophore of fibrates to a BRD4 inhibitor, RVX-208, to design dual-active hypolipidemic compounds, and found that some of new analogues showed favorable hypolipidemic activities. Synthetic accessibility towards this class of compounds optimized RVX-208 as well as would supply more thoughts on hypolipidemic drugs.

  含溴结构域蛋白4（BRD4）是一种新的治疗靶标，用于治疗包括心血管疾病，癌症，炎症和中枢神经系统（CNS）疾病在内的各种疾病。在这项研究中，我们将贝特类药物的药效团引入了BRD4抑制剂RVX-208，以设计具有双重活性的降血脂化合物，并发现一些新的类似物具有良好的降血脂活性。这类化合物的合成可及性优化了RVX-208，并为降血脂药提供了更多的思路。
• POLYMER INTERLAYERS COMPRISING POLY(CYCLOHEXANEDIMETHYLENE TEREPHTHALATE-CO-ETHYLENE TEREPHTHALATE) COPOLYESTER
  申请人：Solutia Inc.

  公开号：EP1910076B1

  公开（公告）日：2016-10-05
• Recycled building material and method thereof
  申请人：Peng L. Richard

  公开号：US20080227914A1

  公开（公告）日：2008-09-18

  The present invention provides a recycled building material such as roof/Geo membrane that comprises (i) a polyolefin, (ii) a polymer containing a carboxyl group or a hydroxyl group, and (iii) a compatabilizer for the components (i) and (ii) which contains an epoxy group or an anhydride group. The present invention also provides a method of recycling building material as well as an article of manufacture such as a TPO membrane using the recycled building material. The TPO membrane has gained better physical properties such as consistent product quality, tensile strength, tear strength, wind resistance, and avoidance of tedious screening processes, among others.
• NUCLEATING AGENT AND INJECTION MOLDING METHOD OF POLYETHYLENE TEREPHALATE
  申请人：LI Hsun-Yu

  公开号：US20100164143A1

  公开（公告）日：2010-07-01

  The invention relates to a nucleating agent for polyethylene terephthalate and injection molding method thereof. The nucleating agent comprises a SiO 2 core grafted with bis(2-hydroxyethyl) terephthalate, which accelerates the crystallization of polyethylene terephthalate for injection molding.
• POLYESTER FIBER FOR AIRBAG AND PREPARATION METHOD THEREOF
  申请人：Kim Young-Jo

  公开号：US20120040167A1

  公开（公告）日：2012-02-16

  The present invention relates to a polyester fiber that can be applied to a fabric for an airbag, and particularly, to a polyester fiber having elongation of 0.5% or more at a stress of 1.0 g/d, elongation of 4.3% or more at a stress of 4.0 g/d, and elongation of 7.5% or more at a stress of 7.0 g/d, and an initial modulus of 40 to 100 g/d, a method of preparing the same, and a fabric for an airbag prepared therefrom. Since the polyester fiber of the present invention remarkably decreases stiffness and secures superior mechanical properties, it is possible to provide superior packing properties, dimensional stability, and gas barrier effect, and to protect occupants safely by minimizing the impact applied to the occupants, when it is used for the fabric for an airbag.