1H-Pyrrole-2-acetic acid, 5-carboxy- | 1378830-31-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1H-Pyrrole-2-acetic acid, 5-carboxy-
• 英文别名: 5-(carboxymethyl)-1H-pyrrole-2-carboxylic acid
• CAS: 1378830-31-9
• 化学式: C₇H₇NO₄
• 分子量: 169.13
• InChiKey: GTTCAMKUPJFPEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] MULTIVALENT LIGANDS TARGETING VEGFR<br/>[FR] LIGANDS MULTIVALENTS CIBLANT VEGFR
  申请人：METHODIST HOSPITAL SYSTEM

  公开号：WO2015175750A1

  公开（公告）日：2015-11-19

  Compounds that target vascular endothelial growth factor receptors for therapy and imaging are disclosed. Methods for making the compounds and detecting or imaging cells expressing VEGFR using the compounds are also provided. In accordance with the purposes of the disclosed subject matter, as embodied and broadly described herein, disclosed are compounds, and methods of making and using the compounds. The disclosed compounds, in one aspect, are quinazoline compounds.

  揭示了针对血管内皮生长因子受体进行治疗和成像的化合物。还提供了制备这些化合物、以及使用这些化合物检测或成像表达VEGFR的细胞的方法。根据所披露主题的目的，如本文所体现和广泛描述的，披露了化合物及制备和使用这些化合物的方法。所披露的化合物在一个方面是喹唑啉化合物。
• [EN] TOLL-LIKE RECEPTOR 2 LIGANDS AND METHODS OF MAKING AND USING THEREOF<br/>[FR] LIGANDS DES RÉCEPTEURS DE TYPE TOLL 2 ET PROCÉDÉS DE FABRICATION ET D'UTILISATION CORRESPONDANTS
  申请人：H LEE MOFFITT CANCER CT & RES

  公开号：WO2016154586A1

  公开（公告）日：2016-09-29

  Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only -1/2 the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

  本发明涉及一类单酰化的Toll样受体2配体，可用于开发针对胰腺癌和其他癌症的靶向剂，用于影像和治疗，以及作为癌症免疫治疗的佐剂。本发明所披露的单酰化化合物与一种已知的有效双酰化激动剂相比，具有更高的TLR2结合亲和力，但仅有1/2的生物活性。已证实单酰化化合物与双酰化化合物竞争结合TLR2。因此，所报告的单酰化化合物是TLR2激活的抑制剂/拮抗剂。
• [EN] MULTIVALENT LIGANDS TARGETING CELL SURFACE RECEPTORS AND FORCE MEASUREMENT PLATFORM FOR MAKING THE SAME<br/>[FR] LIGANDS MULTIVALENTS CIBLANT DES RÉCEPTEURS DE SURFACE CELLULAIRE ET PLATEFORME DE MESURE DE FORCE POUR LEUR FABRICATION
  申请人：THE METHODIST HOSPITAL SYSTEM

  公开号：WO2021155151A1

  公开（公告）日：2021-08-05

  Methods for probing the distribution and distance of the cell surface receptors and using the same to make multivalent ligands targeting said receptors are disclosed. Methods for making the multivalent ligands and detecting or imaging cells expressing receptors using the compounds are also provided.

  本发明揭示了探测细胞表面受体分布和距离的方法，并利用这些方法制备多价配体，以靶向所述受体。本发明还提供了制备多价配体以及使用该化合物检测或成像表达受体的细胞的方法。
• Tetrapyrrole carboxylic acid derivatives for diagnosis and/or therapy of arthritis
  申请人：NIPPON PETROCHEMICALS CO., LTD.

  公开号：EP0629409A1

  公开（公告）日：1994-12-21

  A method and medical agents for the photodynamic diagnosis or photodynamic therapy of rheumatoid arthritis of mammals, which agent comprises at least one member of fluorescent compounds selected from the group consisting of tetrapyrrole carboxylic acids having at least one carboxyl group, corresponding di- or tetrahydrotetrapyrrole carboxylic acids, and mono-, di- or polyamides of the tetrapyrrole carboxylic acids with amino-mono- or dicarboxylic acids and their salts.

  一种用于哺乳动物类风湿性关节炎光动力学诊断或光动力学治疗的方法和医用药剂，该药剂包括至少一种从四吡咯烷羧酸、对应的二或四氢四吡咯烷羧酸和四吡咯烷羧酸的单、二或多酰胺以及它们的氨基单或二羧酸盐中选择的荧光化合物成员。
• Multivalent ligands targeting VEGFR
  申请人：THE METHODIST HOSPITAL SYSTEM

  公开号：US10011587B2

  公开（公告）日：2018-07-03

  Compounds that target vascular endothelial growth factor receptors for therapy and imaging are disclosed. Methods for making the compounds and detecting or imaging cells expressing VEGFR using the compounds are also provided. In accordance with the purposes of the disclosed subject matter, as embodied and broadly described herein, disclosed are compounds, and methods of making and using the compounds. The disclosed compounds, in one aspect, are quinazoline compounds.

  本研究公开了靶向血管内皮生长因子受体的化合物，用于治疗和成像。还提供了制造该化合物和使用该化合物检测或成像表达血管内皮生长因子受体的细胞的方法。根据所公开主题的目的，如本文所体现和广泛描述的，公开了化合物以及制造和使用化合物的方法。所公开的化合物在一个方面是喹唑啉化合物。