1-O-(isobutyryl)glycerol | 62244-25-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-O-(isobutyryl)glycerol
• 英文别名: 3-isobutyryloxy-propane-1,2-diol；3-Isobutyryloxy-propan-1,2-diol；2,3-Dihydroxypropyl 2-methylpropanoate
• CAS: 62244-25-1
• 化学式: C₇H₁₄O₄
• 分子量: 162.186
• InChiKey: OJFADTZZAJISQP-UHFFFAOYSA-N

物化性质

• 沸点：
  272.5±20.0 °C(Predicted)
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  isobutyric acid sodium salt 、 3-氯-1,2-丙二醇 生成 1-O-(isobutyryl)glycerol
  参考文献：
  名称：

  Gilchrist; Schuette, Journal of the American Chemical Society, 1931, vol. 53, p. 34811

  摘要：

  DOI：

文献信息

• Novel condensed imidazole derivative
  申请人：Nakahira Hiroyuki

  公开号：US20070105890A1

  公开（公告）日：2007-05-10

  Disclosed is a compound represented by the formula (1) below which has a high DPP-IV inhibitory activity and is improved in safety, toxicity and the like. Also disclosed is a prodrug of such a compound and pharmaceutically acceptable salts of them. (In the formula, R 1 represents a hydrogen atom, an optionally substituted alkyl group or the like; R 2 and R 3 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; R 4 and R 5 independently represent a hydrogen atom, an optionally substituted alkyl group or the like: R 6 represents a hydrogen atom, an optionally substituted aryl group or the like; and —Y—NH 2 , represents a group represented by the following formula (A): (wherein m is 0, 1 or 2; and R 7 may not exist or one or two R 7 may exist and independently represent an optionally substituted alkyl group or the like) or the like.]

  公开了一种化合物，其表示为以下式（1），具有较高的DPP-IV抑制活性并且在安全性、毒性等方面得到改善。还公开了这种化合物的前药和它们的药学上可接受的盐。（在该式中，R1表示氢原子，可选择性取代的烷基或类似物; R2和R3独立地表示氢原子，可选择性取代的烷基或类似物; R4和R5独立地表示氢原子，可选择性取代的烷基或类似物：R6表示氢原子，可选择性取代的芳基或类似物; 而—Y—NH2表示由以下式（A）表示的基团：（其中m为0、1或2；而R7可能不存在或一个或两个R7可能存在且独立地表示可选择性取代的烷基或类似物）或类似物。）
• TRITERPENOID COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Ip Nancy Yuk-Yu

  公开号：US20110288169A1

  公开（公告）日：2011-11-24

  The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.

  本发明提供了治疗活性化合物和组合物，作为受体拮抗剂以及其使用方法。在一方面，这些化合物可用于通过抑制包括PGE2 EP1、EP2和EP4受体在内的PGE2受体来调节疼痛、炎症和急性相反应。
• RECEPTOR MODULATORS EXHIBITING NEUROPROTECTIVE AND MEMORY ENHANCING ACTIVITIES
  申请人：Ip Nancy Yuk-Yu

  公开号：US20100222286A1

  公开（公告）日：2010-09-02

  The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, methods of enhancing the brain's cognitive functions and methods of treating depression, anxiety and cachexia induced by a chronic disease in mammals and humans.

  本发明提供了作为NMDA和MC受体拮抗剂的治疗活性化合物和组合物，通过抑制NMDA和/或MC受体的过度激活，在预防和治疗中枢神经系统疾病方面具有用途。在一个方面，本发明提供了治疗和/或预防神经退行性疾病和神经病理学疾病的方法，提供在应激条件下如中风下的神经保护方法，提高大脑认知功能的方法以及治疗哺乳动物和人类中由慢性疾病引起的抑郁症、焦虑和消瘦的方法。
• Physiologically stable compositions of butyric acid as well as butyric acid salts and derivatives for treating wounds
  申请人：THE TRUSTEES OF BOSTON UNIVERSITY

  公开号：EP1736152A2

  公开（公告）日：2006-12-27

  This invention is directed to methods of administering physiologically stable and safe compositions of butyric acid salts and derivatives to a patient for the purpose of wound healing.

  本发明涉及向患者施用生理稳定、安全的丁酸盐及其衍生物组合物以促进伤口愈合的方法。
• Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof
  申请人：Johnson & Johnson Consumer Companies, Inc.

  公开号：EP2314273A2

  公开（公告）日：2011-04-27

  Provided are compositions comprising a superhydrophilic amphiphilic copolymer and a carrier and composition comprising a superhydrophilic amphiphilic copolymer, a micellar thickener and a carrier.

  提供了由超亲水两亲共聚物和载体组成的组合物，以及由超亲水两亲共聚物、胶束增稠剂和载体组成的组合物。