4-(3-methoxyphenyl)-1,6-dimethyl-5-(N-phenylcarboxamido)-2-oxo-1,2,3,4-tetrahydropyrimidine | 1255416-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-methoxyphenyl)-1,6-dimethyl-5-(N-phenylcarboxamido)-2-oxo-1,2,3,4-tetrahydropyrimidine
• 英文别名: 3,4-dimethyl-6-(3-methoxyphenyl)-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide；6-(3-methoxyphenyl)-3,4-dimethyl-2-oxo-N-phenyl-1,6-dihydropyrimidine-5-carboxamide
• CAS: 1255416-25-1
• 化学式: C₂₀H₂₁N₃O₃
• 分子量: 351.405
• InChiKey: XFMQQNVKBQFLRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-methoxyphenyl)-1,6-dimethyl-5-(N-phenylcarboxamido)-2-oxo-1,2,3,4-tetrahydropyrimidine 在 [双(三氟乙酰氧基)碘]苯 、 水 、 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 以18%的产率得到4-(3-methoxyphenyl)-1-methyl-4,7-dihydro-1H,3H-furo[3,4-d]pyrimidine-2,5-dione
  参考文献：
  名称：

  An Intramolecular PIFA-Mediated Metal-Free Allylic Oxycarbonylation Reaction and Its Application to the Preparation of Furopyrimidinones

  摘要：

  The preparation of a series of furo[3,4-d]pyrimidinones by an unprecedented PIFA-mediated intramolecular allylic oxycarbonylation reaction developed on 5-carbamoyl-substituted Biginelli adducts is presented The construction of the fused lactone by a metal-free C-H activation process, without the need of an additional functionalization step, is featured in the present work

  DOI：

  10.1021/jo101797s
• 作为产物：
  描述：

  N-乙酰乙酰苯胺 、 3-甲氧基苯甲醛 、 N-甲基脲 在 氯乙酸 作用下， 以97%的产率得到4-(3-methoxyphenyl)-1,6-dimethyl-5-(N-phenylcarboxamido)-2-oxo-1,2,3,4-tetrahydropyrimidine
  参考文献：
  名称：

  An Intramolecular PIFA-Mediated Metal-Free Allylic Oxycarbonylation Reaction and Its Application to the Preparation of Furopyrimidinones

  摘要：

  The preparation of a series of furo[3,4-d]pyrimidinones by an unprecedented PIFA-mediated intramolecular allylic oxycarbonylation reaction developed on 5-carbamoyl-substituted Biginelli adducts is presented The construction of the fused lactone by a metal-free C-H activation process, without the need of an additional functionalization step, is featured in the present work

  DOI：

  10.1021/jo101797s

文献信息

• Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides
  作者：T. M. Zamaraeva、T. F. Odegova、A. Yu. Fedotov、M. V. Tomilov、V. L. Gein、P. A. Slepukhin

  DOI：10.1134/s1070363214100168

  日期：2014.10

  Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, H-1 NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated.
• An Intramolecular PIFA-Mediated Metal-Free Allylic Oxycarbonylation Reaction and Its Application to the Preparation of Furopyrimidinones
  作者：Irantzu Couto、Imanol Tellitu、Esther Domínguez

  DOI：10.1021/jo101797s

  日期：2010.11.19

  The preparation of a series of furo[3,4-d]pyrimidinones by an unprecedented PIFA-mediated intramolecular allylic oxycarbonylation reaction developed on 5-carbamoyl-substituted Biginelli adducts is presented The construction of the fused lactone by a metal-free C-H activation process, without the need of an additional functionalization step, is featured in the present work