6-(2-ethoxyethoxy)pyridazin-3-amine | 90153-99-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(2-ethoxyethoxy)pyridazin-3-amine
• 英文别名: 6-(2-ethoxy-ethoxy)-pyridazin-3-ylamine；3-Amino-6-(2-aethoxy-aethoxy)-pyridazin
• CAS: 90153-99-4
• 化学式: C₈H₁₃N₃O₂
• 分子量: 183.21
• InChiKey: RWLDMHPECGFAHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  395.5±32.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-(2-ethoxyethoxy)pyridazin-3-amine 在 硫酸 、 碳酸氢钠 、 溶剂黄146 作用下， 反应 30.0h， 生成 N-[6-(2-Ethoxy-ethoxy)-2-phenyl-imidazo[1,2-b]pyridazin-3-ylmethyl]-benzamide
  参考文献：
  名称：

  Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo[1,2-b]pyridazines as new ligands for the benzodiazepine receptor

  摘要：

  A series of 2,3-disubstituted-6-alkoxyimidazo[1,2-b] has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM). Imidazo[1,2-b]pyridazines unsubstituted in the 3-position, or containing builder alkoxy groups in the 6-position, were found to bind less strongly to the BZR. Selected compounds from the series were identified from in vitro GABA-shift experiments as BZR agonists. Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazo[1,2-b]pyridazines at the BZR.

  DOI：

  10.1016/0223-5234(96)85873-9
• 作为产物：
  描述：

  乙二醇乙醚 、 3-氨基-6-氯哒嗪 在 sodium 2-ethoxyethoxide 作用下， 以 乙二醇乙醚 为溶剂， 反应 14.0h， 以86%的产率得到6-(2-ethoxyethoxy)pyridazin-3-amine
  参考文献：
  名称：

  Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo[1,2-b]pyridazines as new ligands for the benzodiazepine receptor

  摘要：

  A series of 2,3-disubstituted-6-alkoxyimidazo[1,2-b] has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM). Imidazo[1,2-b]pyridazines unsubstituted in the 3-position, or containing builder alkoxy groups in the 6-position, were found to bind less strongly to the BZR. Selected compounds from the series were identified from in vitro GABA-shift experiments as BZR agonists. Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazo[1,2-b]pyridazines at the BZR.

  DOI：

  10.1016/0223-5234(96)85873-9