2H,3H-heptafluoro-hex-2t-enoic acid ethyl ester | 37759-79-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2H,3H-heptafluoro-hex-2t-enoic acid ethyl ester
• 英文别名: 2H,3H-Heptafluor-hex-2t-ensaeure-aethylester；Heptafluorhexen(2)-saeure-ethylester；Ethyl (2E)-4,4,5,5,6,6,6-heptafluorohex-2-enoate；ethyl (E)-4,4,5,5,6,6,6-heptafluorohex-2-enoate
• CAS: 37759-79-8
• 化学式: C₈H₇F₇O₂
• 分子量: 268.131
• InChiKey: WSGUVPFPADUHPU-ONEGZZNKSA-N

物化性质

• 沸点：
  140-141 °C
• 密度：
  1.368±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2H,3H-heptafluoro-hex-2t-enoic acid ethyl ester 在 盐酸 、 lithium aluminium tetrahydride 、 乙醚 、 乙醇 、 sodium ethanolate 作用下， 生成 4-heptafluoropropyl-tetrahydro-pyran
  参考文献：
  名称：

  Perfluoroalkyl-substituted Dicarboxylic Acids and Derivatives^1,2

  摘要：

  DOI：

  10.1021/ja01566a082
• 作为产物：
  描述：

  4,4,5,5,6,6,6-heptafluoro-3-hydroxy-hexanoic acid ethyl ester 在 phosphorus pentoxide 作用下， 生成 2H,3H-heptafluoro-hex-2t-enoic acid ethyl ester
  参考文献：
  名称：

  One haemodialysis unit's experience of hepatitis B

  摘要：

  SummaryHaemodialysis patients are at high risk of contracting Hepatitis B Virus (HBV). This blood borne virus has been responsible for many critical incidents within haemodialysis units around the world. This paper seeks to explore one such outbreak and at the same time look more closely at HBV and connected issues. The incident discussed occurred within a haemodialysis unit situated in the Northwest of England. This paper is presented as a case study. When HBV was detected in a previously HBV negative patient a crisis management team moved quickly to contain any possible outbreak and sought to discover the origin of the infection. An outline of the personal and financial cost to the organisation, what lessons have been learnt and why recommendations have been made to immunise the local dialysis population again HBV will be presented.

  DOI：

  10.1111/j.1755-6686.2000.tb00071.x

文献信息

• Stereochemistry of the Diels-Alder reaction. V. Fluorinated trans-olefinic acids and derivatives with cyclopentadiene
  作者：Earl T. McBee、Michael J. Keogh、Robert P. Levek、Eugene P. Wesseler

  DOI：10.1021/jo00944a002

  日期：1973.2
• <b>Stereochemistry of the Diels-Alder Reaction. IV. Adducts between Cyclopentadiene and Fluorinated Olefins</b>
  作者：H. P. Braendlin、G. A. Grindahl、Y. S. Kim、E. T. McBee

  DOI：10.1021/ja00870a023

  日期：1962.6
• Perfluoropropyl-substituted Thia-, Oxa- and Aza-dicarboxylic Esters^1,2
  作者：E. T. McBee、C. W. Roberts、Gordon Wilson

  DOI：10.1021/ja01540a053

  日期：1958.4
• Perfluoroalkyl-substituted Dicarboxylic Acids and Derivatives^1,2
  作者：E. T. McBee、C. W. Roberts、Gordon Wilson

  DOI：10.1021/ja01566a082

  日期：1957.5
• One haemodialysis unit's experience of hepatitis B
  作者：A Balshaw、J Casey

  DOI：10.1111/j.1755-6686.2000.tb00071.x

  日期：2000.1.3

  SummaryHaemodialysis patients are at high risk of contracting Hepatitis B Virus (HBV). This blood borne virus has been responsible for many critical incidents within haemodialysis units around the world. This paper seeks to explore one such outbreak and at the same time look more closely at HBV and connected issues. The incident discussed occurred within a haemodialysis unit situated in the Northwest of England. This paper is presented as a case study. When HBV was detected in a previously HBV negative patient a crisis management team moved quickly to contain any possible outbreak and sought to discover the origin of the infection. An outline of the personal and financial cost to the organisation, what lessons have been learnt and why recommendations have been made to immunise the local dialysis population again HBV will be presented.