1-(Diaminomethylidene)-2-(4-methylphenyl)guanidine | 15233-33-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(Diaminomethylidene)-2-(4-methylphenyl)guanidine
• CAS: 15233-33-7
• 化学式: C₉H₁₃N₅
• mdl: MFCD00466365
• 分子量: 191.236
• InChiKey: ILEIGUXOYKZHRK-UHFFFAOYSA-N

物化性质

• 沸点：
  299.5±33.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)
• 溶解度：
  >28.7 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(Diaminomethylidene)-2-(4-methylphenyl)guanidine 在 盐酸 、 氢氧化钾 、 乙醇 作用下， 生成 N2-对甲苯-1,3,5-三嗪-2,4-二胺
  参考文献：
  名称：

  Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status

  摘要：

  Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its. possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats.

  DOI：

  10.1093/gerona/56.10.b426
• 作为产物：
  描述：

  乙烷,三氯氟- 在 盐酸 、 sodium hydroxide 作用下， 以 乙醇 、 正丁醇 为溶剂， 反应 0.5h， 生成 1-(Diaminomethylidene)-2-(4-methylphenyl)guanidine
  参考文献：
  名称：

  The biguanide–sulfonamide derivatives: synthesis, characterization and investigation of anticholinesterase inhibitory, antioxidant and DNA/BSA binding properties

  摘要：

  DOI：

  10.1080/07391102.2023.2184637

文献信息

• [EN] HETEROARYL COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS HÉTÉROARYLE ET LEUR UTILISATION
  申请人：MINORYX THERAPEUTICS S L

  公开号：WO2018122775A1

  公开（公告）日：2018-07-05

  The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.

  该申请涉及式(I)的化合物及其盐和溶剂合物，其中R1、R2、R3、A1、A2、A3和n如规范中所述，以及它们的制备方法，包含它们的药物组合物，以及用于治疗和/或预防溶酶体贮积病（如高雪氏病）和其他α-突触核蛋白病的用途。
• Towards a Universal Polymer Backbone: Design and Synthesis of Polymeric Scaffolds Containing Terminal Hydrogen-Bonding Recognition Motifs at Each Repeating Unit
  作者：Ludger P. Stubbs、Marcus Weck

  DOI：10.1002/chem.200390122

  日期：2003.2.17

  Polymers containing terminal hydrogen-bonding recognition motifs based on diaminotriazine and diaminopyridine groups in their side chains for the self-assembly of appropriate receptors have been prepared by ring-opening metathesis polymerization (ROMP) of norbornenes. A new synthetic method for the preparation of norbornene monomers based on pure alkyl spacers is introduced. These monomers show unprecedented

  已经通过降冰片烯的开环易位聚合（ROMP）制备了在其侧链中含有基于二氨基三嗪和二氨基吡啶基团的末端氢键识别基序的聚合物，以用于合适受体的自组装。介绍了一种基于纯烷基间隔基的降冰片烯单体合成的新方法。这些单体使用ROMP表现出空前的高反应活性。为了抑制基于二氨基三嗪的聚合物的自缔合，在N-丁基胸腺嘧啶的存在下进行聚合。丁基胸腺嘧啶通过自组装到聚合物支架的氢键位上而起保护基的作用，从而使聚合物增溶。由于二氨基吡啶单体的二聚倾向低，因此它们不需要保护基。此外，它们在单体和聚合物水平上都对氢键受体具有很高的亲和力。这些聚合物是我们设计和合成“通用聚合物支架”的第一个基础。
• FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160038612A1

  公开（公告）日：2016-02-11

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

  本公开提供了包含修饰核酸分子的配方组合，该核酸分子可以编码蛋白质、蛋白质前体或蛋白质或蛋白质前体的部分或完全加工形式的组合物。该配方组合还可以包括一种修饰核酸分子和一种传递剂。本发明还提供了用于编码能够调节细胞功能和/或活性的多肽的核酸。
• 1-Substituted biguanides for treating hyperacidity or ulceration
  申请人：William H. Rorer, Inc.

  公开号：US03959488A1

  公开（公告）日：1976-05-25

  The 1-substituted biguanides of this invention possess useful gastric anti-secretory and spasmolytic properties. Compounds of this type which also display anti-hypertensive and CNS depressant properties are also disclosed.

  本发明的1-取代双胍类化合物具有有用的胃抑酸和解痉作用。还披露了具有降压和中枢神经系统抑制作用的该类化合物。
• Stabilization of aqueous hydroxylamine solutions
  申请人：CYTEC TECHNOLOGY CORP.

  公开号：EP0516933A1

  公开（公告）日：1992-12-09

  Solutions of an hydroxylamine or an at least partially neutralized hydroxylamine salt are stabilized against decomposition by adding thereto a thiosulfate, mercaptobenzothiazole, a mercaptothiazoline, a thiuram disulfide, thiourea or a mercaptoalkanol.

  在羟胺或至少部分中和的羟胺盐的溶液中加入硫代硫酸盐、巯基苯并噻唑、巯基噻唑啉、二硫化秋兰姆、硫脲或巯基烷醇，可以稳定溶液，防止分解。