N2-对甲苯-1,3,5-三嗪-2,4-二胺 | 19079-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: N2-对甲苯-1,3,5-三嗪-2,4-二胺
• 英文名称: 2-Amino-4-(4-methyl-anilino)-symm.-triazin
• 英文别名: N-p-Tolyl-[1,3,5]triazine-2,4-diamine；2-N-(4-methylphenyl)-1,3,5-triazine-2,4-diamine
• CAS: 19079-41-5
• 化学式: C₁₀H₁₁N₅
• mdl: MFCD00203357
• 分子量: 201.231
• InChiKey: LBFNSNKYVMKEFX-UHFFFAOYSA-N

物化性质

• 溶解度：
  29.5 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N2-对甲苯-1,3,5-三嗪-2,4-二胺 、 5-Bromosalicyloyl chloride 以35%的产率得到
  参考文献：
  名称：

  MISRA N. C., J. INST. CHEM., 1979, 51, NO 4, 149-150

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(Diaminomethylidene)-2-(4-methylphenyl)guanidine 在 盐酸 、 氢氧化钾 、 乙醇 作用下， 生成 N2-对甲苯-1,3,5-三嗪-2,4-二胺
  参考文献：
  名称：

  Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status

  摘要：

  Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its. possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats.

  DOI：

  10.1093/gerona/56.10.b426

文献信息

• Papini, Gazzetta Chimica Italiana, 1950, vol. 80, p. 844,848
  作者：Papini

  DOI：——

  日期：——
• Clauder; Bulcsu, Magyar Kemiai Folyoirat, 1951, vol. 57, p. 68,71
  作者：Clauder、Bulcsu

  DOI：——

  日期：——
• DE1008303
  申请人：——

  公开号：——

  公开（公告）日：——
• Preparation of synthetic resins from biguanide derivatives and formaldehyde
  申请人：PLASKON CO INC

  公开号：US02273382A1

  公开（公告）日：1942-02-17
• US2217030
  申请人：——

  公开号：——

  公开（公告）日：——