1-(4-methoxyphenyl)-1-phenylhydrazine | 41018-66-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-methoxyphenyl)-1-phenylhydrazine
• 英文别名: p-Methoxydiphenylhydrazine
• CAS: 41018-66-0
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: JUJJALWSNDPNLF-UHFFFAOYSA-N

物化性质

• 熔点：
  58-60 °C
• 沸点：
  387.2±25.0 °C(Predicted)
• 密度：
  1.157±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [Ti(pentamethylcyclopentadienyl)(N(xylyl)C4H6N)(tert-butylimido)(tert-butylamine)] 、 1-(4-methoxyphenyl)-1-phenylhydrazine 以 正己烷 为溶剂， 反应 1.5h， 以61%的产率得到
  参考文献：
  名称：

  Titanium-Catalyzed Hydrohydrazination of Carbodiimides

  摘要：

  Hydrazinediido complexes of the type [Cp*Ti-(NxylN)(NNR2)(L)] (R = Ph, Me; Ar, fluorene, L = (BuNH2)-Bu-t, Py; 3a-e) have been synthesized and used as catalysts for the hydrohydrazination of a series of carbodiimides, yielding aminoguanidines or fluoreneiminoguanidines. The highest yields were obtained for diarylhydrazines and fluorenone 5 hydrazone at temperatures between 80 and 105 degrees C. Stoichiometric reactions of hydraz inediido complexes with (PrNCNPr)-Pr-i-Pr-i led to an equilibrium with the resulting [2 + 2] cydoadducts 4a-f, which were characterized by H-1, C-13, and N-15 NMR spectroscopy as well as X-ray diffraction. The proposed mechanism, which is closely related to that previously established for the hydrohydrazination of alkynes and allenes, was found to be consistent with the results of a kinetic study. The dynamic structures of aminoguanidines and fluoreneiminoguanidines were characterized by NMR spectroscopy, and the minimum configurations were foud to be stabilized by intramolecular hydrogen bonding.

  DOI：

  10.1021/om400323p
• 作为产物：
  描述：

  (E)-1-(2-pyridinyl)methylene-2-phenylhydrazine 在 potassium phosphate 、 copper(l) iodide 、 肼 作用下， 以 1,4-二氧六环 、 乙二醇甲醚 、 水 为溶剂， 生成 1-(4-methoxyphenyl)-1-phenylhydrazine
  参考文献：
  名称：

  通过 Cu 催化的吡啶-2-甲醛腙与芳基卤化物的芳基化反应制备 N,N-二芳基肼的简便途径

  摘要：

  描述了一种铜催化的 C-N 偶联反应，用于通过 N-单或非取代腙与芳基溴化物/碘化物的芳基化制备吡啶-2-甲醛 N,N-二芳基腙，以及随后的转化通过使用 H2NNH2 水溶液的转亚胺化过程将腙转化为 N,N-二芳基肼。该反应的特点是使用 CuI 作为催化剂，无需外部配体。这种方法为从简单、易于获得的前体合成结构多样的 N,N-二芳基肼提供了一种方便的替代方法。

  DOI：

  10.1002/ejoc.201201445

文献信息

• Palladium-Catalyzed Monoarylation of Arylhydrazines with Aryl Tosylates
  作者：Yange Huang、Pui Ying Choy、Junya Wang、Man-Kin Tse、Raymond Wai-Yin Sun、Albert Sun-Chi Chan、Fuk Yee Kwong

  DOI：10.1021/acs.joc.0c01599

  日期：2020.11.20

  A palladium-catalyzed C–N bond coupling reaction between arylhydrazines and aryl tosylates for facile synthesis of unsymmetrical N,N-diarylhydrazines has been developed. Employing the catalyst system of Pd(TFA)2 associated with newly developed phosphine ligand L1, the monoarylation of arylhydrazine proceeds smoothly to afford desired products in good-to-excellent yields (up to 95%) with good functional

  已开发了钯催化的芳基肼与芳基甲苯磺酸酯之间的C–N键偶联反应，可轻松合成不对称的N，N-二芳基肼。利用与新开发的膦配体L1关联的Pd（TFA）2催化剂体系，芳基肼的单芳基化反应顺利进行，以良好的产率（高达95％）提供了具有良好官能团相容性的所需产品。该方法提供了从简单且容易获得的偶联组分中获得结构多样的N，N-二芳基肼的替代合成途径。
• [EN] PYRAZOLIDINOL COMPOUNDS<br/>[FR] COMPOSES A BASE DE PYRAZOLIDINOLE
  申请人：VIRAL AS A

  公开号：WO2001000585A1

  公开（公告）日：2001-01-04

  The invention provides the use of an optionally hydroxy-protected 4-hydroxy or hydroperoxy-3,5-dioxopyrazolidine or an equivalent wherein a pyrazolidine ring attached oxygen is replaced by a sulphur, or a physiologically acceptable salt thereof, for the manufacture of a medicament for use in therapy or prophylaxis. Additionally, the invention provides a method of combatting HIV infection which comprises administering to an HIV-infected patient a T-lymphocyte growth suppressing agent, preferably a pyrazolidinol, in an amount sufficient to suppress T-lymphocyte growth in said patient for a period sufficient to reduce the T-lymphocyte concentration in lymph nodes in said patient by at least 25 % said administration being repeated at intervals of at least 3 months.

  本发明提供了使用可选的羟基保护的4-羟基或羟过氧基-3,5-二氧代吡唑烷或等效物（其中连接氧原子的吡唑烷环被硫代替），或其生理上可接受的盐，用于制备用于治疗或预防的药物。此外，本发明提供了一种抗击HIV感染的方法，该方法包括向HIV感染的患者施用T淋巴细胞生长抑制剂，优选为吡唑烷醇，其量足以在该患者中抑制T淋巴细胞生长，以使得至少25％的T淋巴细胞浓度在该患者的淋巴结中减少，该施用在至少3个月的间隔重复进行。
• Rhodium(<scp>i</scp>)-catalyzed <i>N</i>-arylation of arylazocarboxylates: facile access to unsymmetrical <i>N</i>,<i>N</i>-diarylhydrazides
  作者：Xiaofeng Rao、Wei-An Zhang、Ming-Hua Xu

  DOI：10.1039/d3nj01022h

  日期：——

  A simple, efficient, and broad-scope rhodium(I)-catalyzed direct N-arylation of arylazocarboxylates with arylboronic acids has been developed, allowing access to a diverse range of unsymmetrical N,N-diarylhydrazides from readily available starting materials in high yields under extraordinary mild conditions. The reaction features easy operation, ambient temperature and low catalyst loading (as low

  已开发出一种简单、高效和广泛的铑 ( I ) 催化的芳偶氮羧酸盐与芳基硼酸的直接N-芳基化反应，允许从易于获得的起始原料中以高产率获得各种不对称的N , N-二芳基酰肼非常温和的条件。该反应具有操作简单、环境温度和低催化剂负载量（低至 0.1 mol%）以及广泛的官能团相容性等特点。结果N , N-二芳基酰肼可以作为通用的构建单元来提供其他结构上重要或药学上有趣的分子。该协议为组装有价值的N、N-二芳基胺支架提供了一种有吸引力和互补的方法。
• Platinum complexes and devices
  申请人：Arizona Board of Regents on behalf of Arizona State University

  公开号：US10566553B2

  公开（公告）日：2020-02-18

  Platinum compounds of Formulas I and II useful in a variety of devices, such as, for example organic-light emitting diodes (OLEDs).

  式 I 和式 II 的铂化合物可用于各种设备，例如有机发光二极管（OLED）。
• Matevosyan,R.O.; Ikrina,M.A., Journal of general chemistry of the USSR, 1963, vol. 33, p. 3839 - 3842
  作者：Matevosyan,R.O.、Ikrina,M.A.

  DOI：——

  日期：——