(1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol | 229306-11-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol
• 英文别名: [(1R,2R,3S,4R,5R)-3-acetamido-2-methylsulfanyl-5-phenoxycarbothioyloxy-4-(phenylcarbamoyloxy)cyclopentyl] acetate
• CAS: 229306-11-0
• 化学式: C₂₄H₂₆N₂O₇S₂
• 分子量: 518.612
• InChiKey: WSUDTZGERRNBJZ-ZSYZGHEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  170
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol 在 偶氮二异丁腈 、 三正丁基氢锡 、 sodium methylate 作用下， 以 吡啶 、 盐酸 、 甲醇 、 甲苯 为溶剂， 反应 27.5h， 生成 2-deoxymannostatin A
  参考文献：
  名称：

  Synthesis and α-Mannosidase Inhibitory Activity of Three Deoxy Derivatives of Mannostatin A

  摘要：

  Three deoxy derivatives 2-4 of the alpha-mannosidase inhibitor mannostatin A (1) were synthesized, and their inhibition of Jack bean alpha-mannosidase was evaluated in order to elucidate the roles of each of the three hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives 2 and 3 retained some inhibitory activity, although reduced by a factor of about 100 relative to the parent, whereas it was completely lost with the 3-deoxy derivative 4. Structure and activity relationships are discussed in the light of these findings.

  DOI：

  10.1002/(sici)1099-0690(200005)2000:9<1759::aid-ejoc1759>3.0.co;2-j
• 作为产物：
  描述：

  [(3aR,4R,5S,6R,6aR)-5-acetamido-2-methoxy-2-methyl-4-methylsulfanyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl] N-phenylcarbamate 在 4-二甲氨基吡啶 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成 (1R,2S,3R,4S,5R)-4-acetamido-1-O-acetyl-2-O-phenoxythiocarbonyl-3-O-phenylcarbamoyl-1,2,3-cyclopentanetriol
  参考文献：
  名称：

  Synthesis and biological evaluation of α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A

  摘要：

  Three deoxy derivatives of alpha-mannosidase inhibitor mannostatin A have been synthesized and their inhibitory activity for Jack beans alpha-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives have preserved inhibitory potentials although they lowered the activity one-hundred fold compared to the parent, but the 3-deoxy derivative lost activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00224-3

文献信息

• Synthesis and biological evaluation of α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A
  作者：Seiichiro Ogawa、Takayuki Morikawa

  DOI：10.1016/s0960-894x(99)00224-3

  日期：1999.6

  Three deoxy derivatives of alpha-mannosidase inhibitor mannostatin A have been synthesized and their inhibitory activity for Jack beans alpha-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives have preserved inhibitory potentials although they lowered the activity one-hundred fold compared to the parent, but the 3-deoxy derivative lost activity. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Synthesis and α-Mannosidase Inhibitory Activity of Three Deoxy Derivatives of Mannostatin A
  作者：Seiichiro Ogawa、Takayuki Morikawa

  DOI：10.1002/(sici)1099-0690(200005)2000:9<1759::aid-ejoc1759>3.0.co;2-j

  日期：2000.5

  Three deoxy derivatives 2-4 of the alpha-mannosidase inhibitor mannostatin A (1) were synthesized, and their inhibition of Jack bean alpha-mannosidase was evaluated in order to elucidate the roles of each of the three hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives 2 and 3 retained some inhibitory activity, although reduced by a factor of about 100 relative to the parent, whereas it was completely lost with the 3-deoxy derivative 4. Structure and activity relationships are discussed in the light of these findings.