4,4-dimethoxy-4-phenylbutanal | 1415335-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4-dimethoxy-4-phenylbutanal
• 英文别名: 4,4-Dimethoxy-4-phenylbutanal
• CAS: 1415335-87-3
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: HDLRNLXXCPOXHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,4-dimethoxy-4-phenylbutanal 在 咪唑 、 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 0.08h， 生成 C₃₂H₄₀O₄Si
  参考文献：
  名称：

  Lewis Acid Catalyzed Intramolecular Condensation of Ynol Ether-Acetals. Synthesis of Alkoxycycloalkene Carboxylates

  摘要：

  Treatment of ynol ether-tethered dialkyl acetals with catalytic quantities of scandium triflate in CH3CN gives rise to five-, six-, and seven-membered alkoxycycloalkene carboxylates in good to excellent yields. Tri- and tetrasubstituted carbocyclic and heterocyclic alkenes may be formed by this method, and the products obtained may serve as useful intermediates for natural product synthesis.

  DOI：

  10.1021/ol303026v
• 作为产物：
  描述：

  4,4-Dimethoxy-4-phenylbutanoic acid 在 lithium aluminium tetrahydride 、 草酰氯 、 二甲基亚砜 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.25h， 生成 4,4-dimethoxy-4-phenylbutanal
  参考文献：
  名称：

  Lewis Acid Catalyzed Intramolecular Condensation of Ynol Ether-Acetals. Synthesis of Alkoxycycloalkene Carboxylates

  摘要：

  Treatment of ynol ether-tethered dialkyl acetals with catalytic quantities of scandium triflate in CH3CN gives rise to five-, six-, and seven-membered alkoxycycloalkene carboxylates in good to excellent yields. Tri- and tetrasubstituted carbocyclic and heterocyclic alkenes may be formed by this method, and the products obtained may serve as useful intermediates for natural product synthesis.

  DOI：

  10.1021/ol303026v

文献信息

• Chemoselective Two-Directional Reaction of Bifunctionalized Substrates: Formal Ketal-Selective Mukaiyama Aldol Type Reaction
  作者：Hikaru Yanai、Takashi Matsumoto、Yuichi Sasaki、Yuki Yamamoto

  DOI：10.1055/s-0035-1560478

  日期：——

  In the presence of an acidic zwitterion bearing a highly stabilized carbanion, reactions of ,-dialkoxy carbonyl compounds with ketene silyl acetals (KSA) resulted in an unusual molecular transformation; substitution reaction with the KSA at the ketal moiety and simultaneous silylative acetalization of the ketone moiety.
• Lewis Acid Catalyzed Intramolecular Condensation of Ynol Ether-Acetals. Synthesis of Alkoxycycloalkene Carboxylates
  作者：Vincent Tran、Thomas G. Minehan

  DOI：10.1021/ol303026v

  日期：2012.12.7

  Treatment of ynol ether-tethered dialkyl acetals with catalytic quantities of scandium triflate in CH3CN gives rise to five-, six-, and seven-membered alkoxycycloalkene carboxylates in good to excellent yields. Tri- and tetrasubstituted carbocyclic and heterocyclic alkenes may be formed by this method, and the products obtained may serve as useful intermediates for natural product synthesis.