1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride | 1314863-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride
• 英文别名: 1-(2-Methyl-4-nitrophenyl)pyrrolo[3,2-c]pyridin-4-amine;hydrochloride
• CAS: 1314863-19-8
• 化学式: C₁₄H₁₂N₄O₂*ClH
• 分子量: 304.736
• InChiKey: KDQDFJDPVIATLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.25
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride 、 苯甲酰氯 在 二异丙胺 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以15%的产率得到N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide
  参考文献：
  名称：

  Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines

  摘要：

  Synthesis of a new series of diarylureas and diarylamides having 1H-pyrrolo[3,2-c]pyridine scaffold is described. Their in vitro antiproliferative activity against A375P human melanoma cell line was tested and the effect of substituents on pyrrolo[3,2-c]pyridine nucleus was investigated. The newly synthesized compounds, except three N-tolyl derivatives (8f, 9f, and 9h), generally showed superior activity against A375P to Sorafenib. Among all of these derivatives, compounds 8b, 8g, and 9a-e showed the highest potency against A375P with IC50 in nanomolar range. In addition, compounds 8d, 8e, 8h, 9g, 9i, and 9j were more potent than Sorafenib but with IC50 in micromolar range. Compounds 8b, 8g, 9b-d, and 9i demonstrated higher selectivity towards A375P compared with NIH3T3 fibroblasts. The most potent diarylurea 8g and diarylamide 9d were further tested and showed high potency over nine melanoma cell lines at the NCI. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.031
• 作为产物：
  描述：

  4-硝基-2-甲苯胺 、 4-氯-7-氮杂吲哚 以9.5%的产率得到1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride
  参考文献：
  名称：

  Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines

  摘要：

  Synthesis of a new series of diarylureas and diarylamides having 1H-pyrrolo[3,2-c]pyridine scaffold is described. Their in vitro antiproliferative activity against A375P human melanoma cell line was tested and the effect of substituents on pyrrolo[3,2-c]pyridine nucleus was investigated. The newly synthesized compounds, except three N-tolyl derivatives (8f, 9f, and 9h), generally showed superior activity against A375P to Sorafenib. Among all of these derivatives, compounds 8b, 8g, and 9a-e showed the highest potency against A375P with IC50 in nanomolar range. In addition, compounds 8d, 8e, 8h, 9g, 9i, and 9j were more potent than Sorafenib but with IC50 in micromolar range. Compounds 8b, 8g, 9b-d, and 9i demonstrated higher selectivity towards A375P compared with NIH3T3 fibroblasts. The most potent diarylurea 8g and diarylamide 9d were further tested and showed high potency over nine melanoma cell lines at the NCI. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.031