6-amino-hexanoic acid isopropyl ester | 3173-76-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-amino-hexanoic acid isopropyl ester
• 英文别名: 6-Amino-hexansaeure-isopropylester；Isopropyl 6-aminohexanoate；propan-2-yl 6-aminohexanoate
• CAS: 3173-76-0
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: GGKHBURSQUYOEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  6-amino-hexanoic acid isopropyl ester 以 2-甲基-2-丁醇 为溶剂， 反应 168.0h， 生成 己内酰胺
  参考文献：
  名称：

  Enzymatic formation of lactams in organic solvents

  摘要：

  Porcine pancreatic lipase in organic solvents catalyses the intramolecular cyclisation of aminoesters and the formation of macrocyclic bislactams from diesters and diamines.

  DOI：

  10.1016/s0040-4039(00)74825-8
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 、 镍 、 异丙醇 作用下， 生成 6-amino-hexanoic acid isopropyl ester
  参考文献：
  名称：

  US2777873

  摘要：

  公开号：

文献信息

• Drug-polymer conjugate
  申请人：POLYACTIVA PTY LTD

  公开号：US11207417B2

  公开（公告）日：2021-12-28

  A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.

  一种聚合物-前列腺素共轭物，包括： 由多个式（I）分子组成的聚合物骨架： 其中T代表三唑分子；Q在每次出现时独立选择，可以存在或不存在，存在时代表连接基团；R选自线性或支链烃组成的组；D选自前列腺素；以及L是式(II)的基团，其中R5选自氢和C1至C6烷基；(R)表示与R基团键合的基团的末端；以及(D)表示与基团D连接的基团的末端。
• [EN] PRODRUGS OF GLUTAMINE ANALOGS<br/>[FR] PROMÉDICAMENTS D'ANALOGUES DE GLUTAMINE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2017023774A9

  公开（公告）日：2017-11-23
• DRUG-POLYMER CONJUGATE
  申请人：POLYACTIVA PTY LTD

  公开号：US20200121798A1

  公开（公告）日：2020-04-23

  A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R 5 is selected from hydrogen and C 1 to C 6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.
• BIODEGRADABLE DRUG-POLYMER CONJUGATE
  申请人：POLYACTIVA PTY LTD

  公开号：US20200123322A1

  公开（公告）日：2020-04-23

  A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, β-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci to do alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.