1-[(4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}benzoyl)oxy]-2,5-pyrrolidinedione | 70967-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}benzoyl)oxy]-2,5-pyrrolidinedione
• 英文别名: O,O′-terephthaloyl-bis-N,N′-succinimide ester；bis(2,5-dioxopyrrolidin-1-yl) benzene-1,4-dicarboxylate；p-phthalic acid di-N-succinimide ester；1,4-disuccinimidyl terephthalate；bis(2,5-dioxopyrrolidin-1-yl) terephthalate；terephthalic acid bis-(2,5-dioxo-pyrrolidin-1-yl)ester；2,5-Pyrrolidinedione, 1,1'-[1,4-phenylenebis(carbonyloxy)]bis-
• CAS: 70967-79-2
• 化学式: C₁₆H₁₂N₂O₈
• 分子量: 360.28
• InChiKey: CMPOTSZEEVQDLT-UHFFFAOYSA-N

物化性质

• 沸点：
  547.6±60.0 °C(Predicted)
• 密度：
  1.61±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  8

安全信息

• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  1-[(4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}benzoyl)oxy]-2,5-pyrrolidinedione 生成
  参考文献：
  名称：

  BIFUNCTIONAL PHOTOCROSSLINKING PROBES FOR COVALENT CAPTURE OF PROTEIN-NUCLEIC ACID COMPLEXES IN CELLS

  摘要：

  A new class of molecular probes is provided for real, efficient, stable, and selective capture of protein-nucleic acid complexes inside cells. The molecular probes have a nucleic acid-binding functional group and a photo-reactive diazirine based functional group, separated by a linker of a selected length or with a multi-arm core, thereby generating a photocrosslink between nucleic acids and proteins in close proximity. This is useful in various chromatin research, including the study of interactions between transcription factors and DNA.

  公开号：

  WO2024015963A2
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 对苯二甲酸 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 以86%的产率得到1-[(4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}benzoyl)oxy]-2,5-pyrrolidinedione
  参考文献：
  名称：

  用于双链DNA切割的多核非血红素铁配合物

  摘要：

  博莱霉素模拟物：多核非血红素铁复合物已实现了有效的氧化双链DNA裂解（参见方案）。因此，这些复合物代表模拟抗肿瘤药物博来霉素作用方式的模型化合物。

  DOI：

  10.1002/chem.200801409

文献信息

• Phenobarbital derivatives useful in immunoassay
  申请人：Hui Raymond

  公开号：US20090104713A1

  公开（公告）日：2009-04-23

  Phenobarbital derivatives synthesized out of the alkyl chain at the 5-position, particularly with hydrophilic properties, and carrying an active ester at the end, allow formation of aminodextran conjugates that give curves in the desired range of the assay in the ONLINE TDM microparticle assay format when matched against the Roche FPIA antibody specific for phenobarbital (“an antibody specific for phenobarbital”).

  苯巴比妥衍生物在5位的烷基链上合成，特别具有亲水性，并在末端携带活性酯，允许形成氨基右旋糖苷共轭物，当与罗氏FPIA特异于苯巴比妥的抗体（“特异于苯巴比妥的抗体”）匹配时，在在线TDM微粒子测定法格式中给出所需范围内的曲线。
• Immunoassay for LSD and 2-oxo-3-hydroxy-LSD
  申请人：——

  公开号：US20010044118A1

  公开（公告）日：2001-11-22

  The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens can then be further modified at this functionalized position for linking to appropriate immunogenic or labeling groups to provide reagents for immunoassays having substantially equal specificity for both LSD and 2-oxo-3-hydroxy-LSD.

  本发明提供用于制备抗原、抗体和用于检测LSD和2-氧基-3-羟基LSD的免疫分析试剂的半抗原衍生物。在发明中，2-氧基LSD核心通过吲哚氮原子衍生化，形成氨基烷基衍生物。然后可以在该功能化位置进一步修饰所得的半抗原，以便与适当的免疫原性或标记基团连接，提供对LSD和2-氧基-3-羟基LSD具有基本相等特异性的免疫分析试剂。
• USE OF ORGANIC OXYIMIDES AS FLAME RETARDANT FOR PLASTIC MATERIALS AND ALSO FLAME-RETARDANT PLASTIC MATERIAL COMPOSITION AND MOULDED PARTS PRODUCED THEREFROM
  申请人：FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

  公开号：US20160052927A1

  公开（公告）日：2016-02-25

  The present invention relates to the use of organic oxy imides as flame retardants for plastics. According to the present invention, a flame-retardant plastics composition is likewise specified, including an oxy imide as flame retardant. Additionally specified are mouldings produced from an inventive flame-retardant polymer composition.

  本发明涉及将有机氧基亚酰亚胺用作塑料的阻燃剂。根据本发明，还指定了一种阻燃塑料组合物，其中包括氧基亚酰亚胺作为阻燃剂。此外，还指定了由创新的阻燃聚合物组合物生产的成型件。
• [EN] INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES<br/>[FR] AGONISTES PARTIELS DU RÉCEPTEUR DE L'INSULINE ET ANALOGUES DU GLP-1
  申请人：MERCK SHARP & DOHME

  公开号：WO2017205191A1

  公开（公告）日：2017-11-30

  The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.

  本发明提供了包含胰岛素受体部分激动剂与GLP-1类似物（例如利拉鲁肽）的组合物，以及使用该组合物的方法，例如用于治疗或预防糖尿病或减轻体重。
• [EN] PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY<br/>[FR] DÉRIVÉS DU PHÉNOBARBITAL UTILES DANS DES DOSAGES IMMUNOLOGIQUES
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2009049884A1

  公开（公告）日：2009-04-23

  Phenobarbital derivatives synthesized out of the alkyl chain at the 5-position, particularly with hydrophilic properties, and carrying an active ester at the end, allow formation of aminodextran conjugates that give curves in the desired range of the assay in the ONLINE TDM microparticle assay format when matched against the Roche FPIA antibody specific for phenobarbital ('an antibody specific for phenobarbital').

  通过在5位点处合成的短链烷基苯巴比妥衍生物，特别是具有亲水性质，并在末端携带活性酯，可以形成氨基右旋糖苷共轭物，在与罗氏FPIA特异于苯巴比妥的抗体（“特异于苯巴比妥的抗体”）配对时，在在线TDM微粒测定法格式中产生所需范围内的曲线。