2-(6-chloro-4-phenyl-quinazolin-2-ylamino)-ethanol | 51443-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(6-chloro-4-phenyl-quinazolin-2-ylamino)-ethanol
• 英文别名: 6-chloro-2-(2-hydroxyethylamino)-4-phenylquinazoline；6-Chlor-2-(β-hydroxyethylamin)-4-phenyl-chinazolim；2-[(6-Chloro-4-phenylquinazolin-2-yl)amino]ethanol
• CAS: 51443-53-9
• 化学式: C₁₆H₁₄ClN₃O
• 分子量: 299.76
• InChiKey: YKQYBJKPSXUFHR-UHFFFAOYSA-N

物化性质

• 沸点：
  514.9±60.0 °C(Predicted)
• 密度：
  1.358±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  58
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(6-chloro-4-phenyl-quinazolin-2-ylamino)-ethanol 、 硫代乙酸 在 三苯基膦 、 N,N'-二异丙基碳二亚胺 、 碳酸氢钠 作用下， 以 四氢呋喃 、 甲苯 、 水 为溶剂， 生成 2-(2-acetylthioethylamino)-6-chloro-4-phenylquinazoline
  参考文献：
  名称：

  QUINAZOLINE DERIVATIVES CAPABLE OF INHIBITING CYTOKININ SIGNALING

  摘要：

  公开号：

  EP2100507B1

文献信息

• AGENT FOR INHIBITING CYTOKININ SIGNALING
  申请人：Nagasawa Asako

  公开号：US20100056377A1

  公开（公告）日：2010-03-04

  Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical substance capable of promoting the growth of a root of a plant, which comprises measuring the level of intracellular signaling from the receptor in a system where a cell having the receptor is contacted with a chemical substance having an agonistic activity on the receptor and a substance to be tested, comparing the level of intracellular signaling measured in the preceding step with a level of intracellular signaling measured in the absence of the chemical substance, and determining the chemical substance as being a chemical substance capable of promoting the growth of a root of a plant based on the difference obtained by the comparison; and others.

  本发明涉及一种具有抑制植物来源细胞因子受体内部信号传递活性的物质，可控制植物的生长或分化。同时，还揭示了一种搜寻促进植物根生长的化学物质的方法，其中包括测量具有激动剂活性的化学物质与待测试物质接触的受体细胞系统中的细胞内信号传递水平，将前一步骤中测量的细胞内信号传递水平与无化学物质存在时测量的细胞内信号传递水平进行比较，并根据所得到的差异确定该化学物质为能够促进植物根生长的化学物质。
• Agent for inhibiting cytokinin signaling
  申请人：Nagasawa Asako

  公开号：US08722580B2

  公开（公告）日：2014-05-13

  Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical substance capable of promoting the growth of a root of a plant, which comprises measuring the level of intracellular signaling from the receptor in a system where a cell having the receptor is contacted with a chemical substance having an agonistic activity on the receptor and a substance to be tested, comparing the level of intracellular signaling measured in the preceding step with a level of intracellular signaling measured in the absence of the chemical substance, and determining the chemical substance as being a chemical substance capable of promoting the growth of a root of a plant based on the difference obtained by the comparison; and others.

  本发明公开了一种具有抑制植物源细胞因子受体内部信号传递活性的物质，可以控制植物的生长或分化。此外，还公开了一种搜索能够促进植物根生长的化学物质的方法，该方法包括测量具有激动剂活性的化学物质和待测试物质接触的具有受体的细胞系统中受体内部信号传递水平，将前一步骤中测量的内部信号传递水平与没有化学物质时测量的内部信号传递水平进行比较，并根据比较得到的差异确定该化学物质为能够促进植物根生长的化学物质。
• SUBSTANCE CAPABLE OF INHIBITING CYTOKININ SIGNALING
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2100507A1

  公开（公告）日：2009-09-16

  Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical substance capable of promoting the growth of a root of a plant, which comprises measuring the level of intracellular signaling from the receptor in a system where a cell having the receptor is contacted with a chemical substance having an agonistic activity on the receptor and a substance to be tested, comparing the level of intracellular signaling measured in the preceding step with a level of intracellular signaling measured in the absence of the chemical substance, and determining the chemical substance as being a chemical substance capable of promoting the growth of a root of a plant based on the difference obtained by the comparison; and others.

  公开了一种物质，该物质具有抑制来自植物的细胞分裂素受体的细胞内信号传导的活性，并能控制植物的生长或分化。此外，还公开了一种寻找能够促进植物根部生长的化学物质的方法，该方法包括在一个系统中测量来自受体的细胞内信号水平，在该系统中，具有受体的细胞与对受体具有激动活性的化学物质和待测物质接触、将前一步骤中测得的细胞内信号水平与没有该化学物质时测得的细胞内信号水平进行比较，并根据比较得出的差异确定该化学物质是能够促进植物根部生长的化学物质；及其他。
• US8722580B2
  申请人：——

  公开号：US8722580B2

  公开（公告）日：2014-05-13
• QUINAZOLINE DERIVATIVES CAPABLE OF INHIBITING CYTOKININ SIGNALING
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2100507B1

  公开（公告）日：2015-02-25