Dimethyl 5-(2-ethoxy-2-oxoethyl)imino-2,2-bis(trichloromethyl)furan-3,4-dicarboxylate | 1116653-35-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Dimethyl 5-(2-ethoxy-2-oxoethyl)imino-2,2-bis(trichloromethyl)furan-3,4-dicarboxylate
• 英文别名: dimethyl 5-(2-ethoxy-2-oxoethyl)imino-2,2-bis(trichloromethyl)furan-3,4-dicarboxylate
• CAS: 1116653-35-0
• 化学式: C₁₄H₁₃Cl₆NO₇
• 分子量: 519.978
• InChiKey: BYRKQMFFJXOQMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  六氯丙酮 、 异氰基乙酸乙酯 、 丁炔二酸二甲酯 以 二氯甲烷 为溶剂， 反应 24.0h， 以75%的产率得到Dimethyl 5-(2-ethoxy-2-oxoethyl)imino-2,2-bis(trichloromethyl)furan-3,4-dicarboxylate
  参考文献：
  名称：

  Efficient synthesis of functionalized 2,5-dihydrofurans and 1,5-dihydro-2H-pyrrol-2-ones by reaction of isocyanides with activated acetylenes in the presence of hexachloroacetone

  摘要：

  Isocyanides react smoothly with dimethyl acetylenedicarboxylate in the presence of hexachloroacetone to produce dimethyl 5-[alkyl(aryl)imino]-2,2-bis(trichloromethyl)-2,5-dihydro-furan-3,4-dicarboxylates in high yields. When the reaction was performed with dibenzoylacetylene, 3-benzoyl-1-alkyl-4-chloro-5-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-ones were obtained.

  DOI：

  10.1007/s00706-007-0810-3

文献信息

• Efficient synthesis of functionalized 2,5-dihydrofurans and 1,5-dihydro-2H-pyrrol-2-ones by reaction of isocyanides with activated acetylenes in the presence of hexachloroacetone
  作者：Issa Yavari、Maryam Sabbaghan、Zinatossadat Hossaini

  DOI：10.1007/s00706-007-0810-3

  日期：2008.6

  Isocyanides react smoothly with dimethyl acetylenedicarboxylate in the presence of hexachloroacetone to produce dimethyl 5-[alkyl(aryl)imino]-2,2-bis(trichloromethyl)-2,5-dihydro-furan-3,4-dicarboxylates in high yields. When the reaction was performed with dibenzoylacetylene, 3-benzoyl-1-alkyl-4-chloro-5-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-ones were obtained.