mitaplatin | 1214738-84-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: mitaplatin
• 英文别名: Azane;2,2-dichloroacetate;platinum(4+);dichloride
• CAS: 1214738-84-7
• 化学式: C₄H₈Cl₆N₂O₄Pt
• 分子量: 555.917
• InChiKey: SFQVINCQRGGSPW-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  -6.59
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  82.3
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  mitaplatin 生成 cisplatin
  参考文献：
  名称：

  Glassy carbon electrodes deliver unpredictable reduction potentials for platinum(IV) antitumor prodrugs

  摘要：

  Reductive activation of six-coordinate Pt(IV) complexes to afford square-planar Pt(II) complexes has exhibited surprisingly divergent and unpredictable cathodic peak potentials during cyclic voltammetry (CV) measurements under widely employed experimental conditions. A systematic, detailed investigation reveals that glassy carbon (GC) electrodes are responsible for this erratic behavior. More reproducible CVs are obtained with platinum metal electrodes, which display cathodic responses at much more positive potentials. The unreliable and negatively shifted peak potentials observed at GC are attributed to a non-uniform oxide layer that is formed on the electrode surface causing slow electron transfer. A simple procedure of repetitive scanning to reducing potentials is found to be effective for cleaning and activating the GC surface, such that it exhibits the more consistent and accurate peak potential responses seen with a Pt electrode. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2015.09.040
• 作为产物：
  描述：

  氧代铂 、 二氯乙酰氯 以 丙酮 为溶剂， 反应 12.0h， 生成 mitaplatin
  参考文献：
  名称：

  一种线粒体调控型铁基磁性配位聚合物纳米粒及其制备方法和应用

  摘要：

  本发明公开了一种线粒体调控型铁基磁性配位聚合物纳米粒及其制备方法和应用，属于医药技术领域。所述聚合物纳米粒包括：多巴胺修饰的透明质酸、氧化铁纳米粒和二氯乙酸修饰的顺铂；其中：多巴胺上的邻二酚羟基与氧化铁通过配位络合，透明质酸上的多羧基与铂原子通过配位络合。该聚合物纳米粒通过将二氯乙酸与顺铂联合，在肿瘤细胞内可以通过线粒体和NOX双作用位点极大提高胞内H2O2的含量，再与磁性氧化铁催化产生高毒性的活性氧羟基自由基，引发肿瘤细胞凋亡；此外，磁性氧化铁可产生T2磁共振成像效果，准确获得肿瘤空间位置及大小信息。

  公开号：

  CN112656960B

文献信息

• PLATINUM (IV) COMPLEXES FOR USE IN DUAL MODE PHARMACEUTICAL THERAPY
  申请人：Lippard Stephen J.

  公开号：US20110257261A1

  公开（公告）日：2011-10-20

  The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects in need of therapeutic protocol, including subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a first component comprising a precursor to a therapeutically active platinum agent and a precursor to a second therapeutically active agent. The therapeutically active platinum agent and the second therapeutically active agent may dissociate from each other, thereby forming a first therapeutically active platinum agent and a second therapeutically active agent. The second therapeutically active gent may affect a cellular pathway of a cancer cell and may be substantially inactive towards non-cancerous cells.

  本发明提供了用于治疗需要治疗方案的对象的组合物、制剂、配方、套装和方法，包括患有癌症或有癌症风险的对象。本发明的某些实施例可能包括一种组合物，该组合物包括第一组分，该第一组分包括治疗活性铂类药物的前体和第二治疗活性剂的前体。治疗活性铂类药物和第二治疗活性剂可以相互解离，从而形成第一治疗活性铂类药物和第二治疗活性剂。第二治疗活性剂可以影响癌细胞的细胞通路，并且对非癌细胞几乎没有活性。
• Glassy carbon electrodes deliver unpredictable reduction potentials for platinum(IV) antitumor prodrugs
  作者：Meghan C. McCormick、Franklin A. Schultz、Mu-Hyun Baik

  DOI：10.1016/j.poly.2015.09.040

  日期：2016.1

  Reductive activation of six-coordinate Pt(IV) complexes to afford square-planar Pt(II) complexes has exhibited surprisingly divergent and unpredictable cathodic peak potentials during cyclic voltammetry (CV) measurements under widely employed experimental conditions. A systematic, detailed investigation reveals that glassy carbon (GC) electrodes are responsible for this erratic behavior. More reproducible CVs are obtained with platinum metal electrodes, which display cathodic responses at much more positive potentials. The unreliable and negatively shifted peak potentials observed at GC are attributed to a non-uniform oxide layer that is formed on the electrode surface causing slow electron transfer. A simple procedure of repetitive scanning to reducing potentials is found to be effective for cleaning and activating the GC surface, such that it exhibits the more consistent and accurate peak potential responses seen with a Pt electrode. (C) 2015 Elsevier Ltd. All rights reserved.
• 一种线粒体调控型铁基磁性配位聚合物纳米粒及其制备方法和应用
  申请人：中国药科大学

  公开号：CN112656960B

  公开（公告）日：2022-09-20

  本发明公开了一种线粒体调控型铁基磁性配位聚合物纳米粒及其制备方法和应用，属于医药技术领域。所述聚合物纳米粒包括：多巴胺修饰的透明质酸、氧化铁纳米粒和二氯乙酸修饰的顺铂；其中：多巴胺上的邻二酚羟基与氧化铁通过配位络合，透明质酸上的多羧基与铂原子通过配位络合。该聚合物纳米粒通过将二氯乙酸与顺铂联合，在肿瘤细胞内可以通过线粒体和NOX双作用位点极大提高胞内H2O2的含量，再与磁性氧化铁催化产生高毒性的活性氧羟基自由基，引发肿瘤细胞凋亡；此外，磁性氧化铁可产生T2磁共振成像效果，准确获得肿瘤空间位置及大小信息。