1H-3-(2'-oxazolyl)indole | 141690-90-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1H-3-(2'-oxazolyl)indole
• 英文别名: 3-(2'-oxazolyl)indole；2-(1H-indol-3-yl)-1,3-oxazole
• CAS: 141690-90-6
• 化学式: C₁₁H₈N₂O
• 分子量: 184.197
• InChiKey: RQPIOHYJYNQWTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1H-吲哚-3-羧酰胺 、 氯乙醛缩二乙醇 以 乙醇 为溶剂， 反应 15.0h， 以50%的产率得到1H-3-(2'-oxazolyl)indole
  参考文献：
  名称：

  Synthesis of camalexin and related phytoalexins

  摘要：

  A number of 3-(2'-thiazoyl)indoles, including two recently reported phytoalexins, have been prepared from the Grignard reaction of the corresponding substituted indole and 2-bromothiazole. The antifungal activity of these 3-(2'-thiazoyl)indoles and 3-(2'-oxazolyl)indole have been examined.

  DOI：

  10.1016/s0040-4020(01)90973-1

文献信息

• [EN] PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS<br/>[FR] DÉRIVÉS DE PYRROLO[2,3-B]PYRAZINE-7-CARBOXAMIDE ET LEUR UTILISATION COMME INHIBITEURS DE JAK ET SYK
  申请人：HOFFMANN LA ROCHE

  公开号：WO2011144585A1

  公开（公告）日：2011-11-24

  The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables Q and R, R2, and R3 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用式（I）的新型吡咯吡嗪衍生物，其中变量Q和R，R2和R3如本文所述定义，其抑制JAK和SYK并且适用于治疗自身免疫和炎症性疾病。
• [EN] SYNTHESIS OF DIAZONAMIDE "A" CORE<br/>[FR] SYNTHESE DE NOYAU DE DIAZONAMIDE "A"
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2003106438A1

  公开（公告）日：2003-12-24

  Using a novel samarium (II)-based macrocyclization cascade reaction, the entire highly strained ABCDEF aromatic core of diazonamide "A" and several novel analogies thereof are constructed.

  利用一种新型钐(II)基宏环化级联反应，构建了diazonamide "A"的整个高度紧张的ABCDEF芳香核心以及几种新颖的类似物。
• [EN] PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS<br/>[FR] DÉRIVÉS DE PYRROLOPYRAZINE COMME INHIBITEURS DE SYK ET JAK
  申请人：HOFFMANN LA ROCHE

  公开号：WO2011144584A1

  公开（公告）日：2011-11-24

  The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用新型吡咯吡嗪衍生物的方法，其化学式如下（I），其中变量Q和R1和R2的定义如本文所述，该方法抑制JAK和SYK，适用于治疗自身免疫性和炎症性疾病。
• Pyrrolopyrazine Kinase Inhibitors
  申请人：Hendricks Robert Than

  公开号：US20110288097A1

  公开（公告）日：2011-11-24

  The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R 1 and R 2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用新型吡咯吡嗪衍生物（式I），其中变量Q和R1和R2如本文所述，其抑制JAK和SYK并且适用于治疗自身免疫和炎症性疾病。
• PYRROLOPYRAZINE KINASE INHIBITORS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20140155376A1

  公开（公告）日：2014-06-05

  The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R, R 2 , and R 3 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用公式I中的新型吡咯吡嗪衍生物，其中变量Q和R，R2和R3的定义如本文所述，它们抑制JAK和SYK，并且对于治疗自身免疫和炎症性疾病是有用的。