eicosanedihydrazide | 38291-94-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: eicosanedihydrazide
• 英文别名: eicosanedioic acid dihydrazide；Icosanedihydrazide
• CAS: 38291-94-0
• 化学式: C₂₀H₄₂N₄O₂
• 分子量: 370.579
• InChiKey: AQTNCAREYVLVMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• HYALURONAN CONJUGATES AND USES THEREOF
  申请人：Aihol Corporation

  公开号：US20200376132A1

  公开（公告）日：2020-12-03

  Disclosed herein is a hyaluronan conjugate, which includes a hyaluronic acid (HA), a sex hormone, and a linker for coupling one of the disaccharide units of the HA and the sex hormone. Also disclosed herein are the uses of the hyaluronan conjugate in treating or preventing neurodegenerative diseases.

  本文披露了一种透明质酸偶联物，其中包括透明质酸（HA），性激素和用于耦合HA和性激素的二糖单元之一的连接剂。本文还披露了使用透明质酸偶联物治疗或预防神经退行性疾病的用途。
• Thermoplastic resin composition comprising a polyamide
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0258040A1

  公开（公告）日：1988-03-02

  A thermoplastic synthetic resin composition having a flexural modulus as defined in JIS K7203 of from 500 to 15,000 kg/cm² is obtained by partial crosslinking upon melt kneading a mixture of by weight: (A) from 20 to 60 parts of a polyamide resin; and (B) from 80 to 40 parts of an ethylene copolymer comprising the units (a) 40 to 90% of ethylene, (b) 5 to 60% of an α,β-unsaturated carboxylic acid alkyl ester, and (c) from 0.3 to 10% of maleic anhydride or a partially ionized maleic anhydride; with (C) from 0.01 to 20 parts, based on 100 parts by weight of the sum of the components (A) and (B), of a polyfunctional compound containing in its molecule at least two functional groups, e.g. an amino, epoxy, dihydrooxazolyl, carboxyl, carboxylic anhydride or hydroxyl group, which are reactive to a carboxyl, carboxylic anhydride or amino group. The composition is moldable and the excellent moldings have impact strength at low temperatures, low heat distortion, and high tensile strength at break and have a good balance between mechanical properties and thermal properties.

  一种热塑性合成树脂组合物，其弯曲模量在 JIS K7203 中定义为 500 至 15,000 kg/cm²，是通过部分交联熔融捏合按重量计的混合物而获得的： (A) 20 至 60 份聚酰胺树脂；和 (B) 80 至 40 份乙烯共聚物，其单元包括 (a) 40 至 90%的乙烯，(b) 5 至 60%的α，β-不饱和羧酸烷基酯，和 (c) 0.3 至 10%的顺丁烯二酸酐或部分离子化顺丁烯二酸酐；与 (C) 以 100 份组分(A)和(B)的重量总和为基准，0.01 至 20 份的多官能团化合物， 其分子中含有至少两个官能团，如氨基、环氧基、二氢恶唑基、羧基、羧酸酐或羟基， 这些官能团可与羧基、羧酸酐或氨基反应。 该组合物可模塑，其优良的模塑物具有低温冲击强度、低热变形和高断裂拉伸强度，并且在机械性能和热性能之间具有良好的平衡。
• Process for producing polymeric polyamide resin composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0284379A2

  公开（公告）日：1988-09-28

  A polyamide resin composition is produced by melt kneading (A) 20 to 60 parts of a polyamide resin and (B) 40 to 80 parts of an ethylene copolymer comprising (a) 40 to 90 wt% of an ethylene unit, (b) 5 to 60 wt% of an α,β-unsaturated carboxylic acid alkyl ester unit and (c) 0.3 to 10 wt% of a maleic anhydride unit to form a partially crosslinked composition (I) and adding 50 to 1,000 parts by weight of a polyamide resin to 100 parts by weight of the composition (I) and melt kneading the resulting mixture. The resultant composition is moldable and has excellent impact resistance. Preferably to the composition (I) is added a poly­functional compound which reacts with (B) and (C) and causes cross-linking thereof in the kneading.

  一种聚酰胺树脂组合物是通过熔融捏合(A)20 至 60 份聚酰胺树脂和(B)40 至 80 份乙烯共聚物生产的，乙烯共聚物包括(a)40 至 90 wt%的乙烯单元，(b)5 至 60 wt%的 α，β-不饱和羧酸烷基酯单元和(c)0.3 至 10 wt%的马来酸酐单元，以形成部分交联的组合物 (I)，然后将 50 至 1,000 重量份的聚酰胺树脂加入 100 重量份的组合物 (I)中，并熔融捏合所得混合物。 这样得到的组合物具有良好的可模塑性和抗冲击性。 最好在组合物(I)中加入一种多官能化合物，它能与(B)和(C)发生反应，并在捏合过程中使其交联。
• Moldable thermoplastic polyamide composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0279578A1

  公开（公告）日：1988-08-24

  A composition is prepared by melt-kneading (A) 60-97 parts by wt of a polyamide (e.g. aliphatic polyamide 6, 6.6 or 12) and (B) 3-40 parts of an ethylene copolymer of (a) 40-90% by wt of an ethylene unit, (b) 5-60% by wt of an alkyl α,β-unsaturated C3-8 carboxylate unit (e.g. methyl methacrylate), and optionally other copolymerizable monomers; and 0.3-10% of maleic anhydride unit, the copolymer having a melt index of 1-100 g/10 mm; and then melt-kneading the composition with (c) 0-01-20 parts of a polyfunctional compound having at least 2 functional groups reactive to carboxyl, carboxylic acid anhydride or amino (e.g. amino, epoxy, dihydxyazolyl, carboxyl, carboxylic acid anhydride and hydroxyl), e.g. an aliphatic diamine or a polyamine; this effects partial crosslinking. Melt kneading can be performed in an extruder. The resultant resin composition can also contain other additives or reinforcements, and can be molded to make articles having good physical properties and appearance.

  一种组合物的制备方法是：将(A)60-97 份重量的聚酰胺（如脂肪族聚酰胺 6、6.6 或 12）和(B)3-40 份重量的乙烯共聚物（a）40-90% 的乙烯单元，(b)5-60% 的α，β-不饱和 C3-8 羧酸烷基单元（如甲基丙烯酸甲酯）和任选的其他可共聚单体；以及 0.3-10%的马来酸酐单元，该共聚物的熔融指数为 1-100 克/10 毫米；然后用 (c) 0-01-20 份具有至少 2 个与羧基、羧酸酐或氨基（如氨基、环氧基、二羟基唑基、羧基、羧酸酐和羟基）反应的官能团的多官能团化合物（如脂肪族二胺或多胺）对该组合物进行熔融捏合；这可实现部分交联。 熔融捏合可在挤压机中进行。 由此产生的树脂组合物还可以含有其他添加剂或增强剂，并可以通过模塑制成具有良好物理性能和外观的物品。
• Room-temperature stable, one-component, thermally-conductive, flexible epoxy adhesives
  申请人：HE HOLDINGS, INC. dba HUGHES ELECTRONICS

  公开号：EP0754741A2

  公开（公告）日：1997-01-22

  A flexible thermally-conductive epoxy-based adhesive composition and method for making the same are provided. The present adhesive composition comprises (a) a polymer mixture comprising at least one polyepoxide resin having a hardness not exceeding a durometer Shore D reading of about 45, when cured with a stoichiometric amount of diethylene triamine ("DETA"), and a substantially stoichiometric amount of at least one latent epoxy resin curing agent; and (b) a thermally-conductive filler. Optional components include secondary epoxy resins, non-reactive flexibilizers, diluents, and processing aids. The present adhesive composition is rheologically stable for weeks or even months at room temperature and is curable in less than one hour at a temperature ranging from about 100°C to 140°C, whereupon the cured adhesive composition exhibits a durometer Shore A of less than about 90 and a thermal conductivity exceeding 0.4 BTU/hr-ft-°F (0.7 W/m-K).

  提供了一种柔性导热环氧基粘合剂组合物及其制造方法。本粘合剂组合物包括：(a) 聚合物混合物，该混合物包含至少一种聚环氧树脂，该树脂在用一定量的二乙三胺（"DETA"）和一定量的至少一种潜伏环氧树脂固化剂固化时，硬度不超过硬度计 Shore D 读数约 45；(b) 热导性填料。可选成分包括辅助环氧树脂、非反应性柔顺剂、稀释剂和加工助剂。本粘合剂组合物在室温下具有数周甚至数月的流变稳定性，并可在约 100°C 至 140°C 的温度下在一小时内固化，固化后的粘合剂组合物的硬度计邵氏 A 值小于约 90，导热系数超过 0.4 BTU/hr-ft-°F (0.7 W/m-K)。